The Weight of Vitamin D on Obesity Outcomes: What Do We Know?

Bialo, Shara R.; Gordon, Catherine M.

doi:10.1016/j.jadohealth.2015.04.020

Cited by 5 publications

(6 citation statements)

References 21 publications

(15 reference statements)

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“…Adolescents with overweight or obesity have been previously shown to have a higher likelihood of vitamin D deficiency. 9,32 Our findings support this premise, as 25(OH)D levels in the current cohort of adolescents with BMI ≥ 85th percentile were profoundly low, independent of having sustained a fracture. For neither 25(OH)D levels of “insufficiency” or “deficiency,” an association with fractures could be defined.…”

Section: Discussionsupporting

confidence: 81%

“…Both factors have been shown to predispose to low 25(OH)D levels. 9,32,34 Accordingly, a "floor effect" may have resulted in the 25(OH)D concentration among cases to resemble the low mean level found in the control group. A decline in 25(OH)D concentrations during the weeks following a fracture has been previously described 35 and could have influenced data interpretation.…”

Section: Discussionmentioning

confidence: 99%

“…Adolescents with overweight or obesity are at risk for vitamin D deficiency. 9 Vitamin D deficiency has been previously associated with a wide range of medical (e.g., autoimmune, inflammatory, etc.) and psychological conditions.…”

Section: Introductionmentioning

confidence: 99%

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Relationship Between Hypovitaminosis D and Fractures Among Adolescents With Overweight or Obesity

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Ziv

Meisman

et al. 2022

Clin Pediatr (Phila)

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Adolescents with overweight/obesity are at risk for vitamin D insufficiency and deficiency. Both overweight/obesity and vitamin D insufficiency/deficiency may predispose to fractures. We enrolled 103 participants (53.3% females, 15.9 ± 2.2 years) in a retrospective case-control study to determine whether an association exists between fractures and a low 25-hydroxyvitamin D (25[OH]D) among adolescents whose body mass index (BMI) ≥ 85 percentile. Cases (n = 28) sustaining a low/medium impact fracture were matched to controls (n = 75) without a fracture history. A conditional-logistic regression analysis addressing the common vitamin D insufficiency/deficiency cutoffs was used. Overweight, obesity, and significant obesity rates were 10.7%, 53.4%, and 35.9%, respectively. Mean (±SD) 25(OH)D was 16.5 ± 6.4 ng/mL. In all, 25(OH)D insufficiency rates (level <20 ng/mL) were 70.5%. Matched cases and controls had similar 25(OH)D insufficiency/deficiency rates ( P > .05). Controlling for race and seasonality showed no association between fractures and 25(OH)D insufficiency/deficiency ( P > .05). These data suggest that fractures are not associated with low 25(OH)D levels among adolescents whose BMI ≥ 85th percentile.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

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Relationship Between Hypovitaminosis D and Fractures Among Adolescents With Overweight or Obesity

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Ziv

Meisman

et al. 2022

Clin Pediatr (Phila)

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“…According to the World Health Organization (WHO), obesity is characterized by an excess storage of fat arising from an imbalance between energy intake and energy expenditure (EE) (Blomain et al., 2013). It is well known that individuals with obesity are at a greater risk for numerous medical conditions (Pourshahidi, 2015), such as chronic and life‐threatening disorders like type 2 diabetes (Jafari‐Adli et al., 2014), cardiovascular disease, hyperlipidemia, and sleep apnea, which consequently impose a huge financial burden on the healthcare system (Bialo, 2015). This chronic disease is a multifaceted problem with many contributing factors including but not limited to genetics, overeating, and sedentary lifestyle.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, it is different from lean to obese individuals (Carlson et al., 2009; le Roux et al., 2006; Zwirska‐Korczala et al., 2007). There is overwhelming evidence showing that ghrelin secretion attenuates during diet‐induced obesity (DIO) (Bialo et al, 2015; Zigman et al, 2016). Furthermore, in DIO, ghrelin can no longer respond to food intake, which induces hyperphagia (Yang et al., 2009).…”

Section: Introductionmentioning

confidence: 99%

Consumption of probiotic yogurt and vitamin D‐fortified yogurt increases fasting level of GLP‐1 in obese adults undergoing low‐calorie diet: A double‐blind randomized controlled trial

Hajipoor

Hekmatdoost²,

Pasdar

et al. 2022

Food Science & Nutrition

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Energy restriction and manipulation of macronutrient composition of the diet are the main approaches that are used by people who aim to lose weight. When such strategies are employed, appetite and endocrine regulators of satiety, such as gut peptides, all are deeply affected. The gut microbiota–brain axis controls energy homeostasis in humans by affecting central satiety and gut peptides. The purpose of this study was to evaluate if the synergistic effect of probiotics and vitamin D in yogurt matrix can modulate this effect. In the double‐blind, randomized, placebo‐controlled trial, 140 obese adults were randomly allocated into four groups: 1) regular yogurt plus low‐calorie diet; 2) PY plus low‐calorie diet; 3) vitamin D‐fortified yogurt plus low‐calorie diet, and 4) probiotic and vitamin D co‐fortified yogurt plus low‐calorie diet. All groups were encouraged to increase their physical activity. Glucagon‐like peptide‐1 (GLP‐1), peptide Tyrosin‐Tysrosin (PYY), ghrelin, anthropometric variables, insulin, fasting blood sugar (FBS), insulin resistance/sensitivity, 1,25(OH)2 D3, dietary intake, and physical activity were measured before and after 10 weeks. The difference between groups for GLP‐1 after 10 weeks was significant after adjusting for baseline GLP‐1 and protein intake as confounders. PY showed the largest effect size (ES) on GLP‐1 (p = 14.2) and FBS (p = 14) compared with others. Pairwise comparison of yogurts effect sizes on GLP‐1 showed a significant difference in group 1 vs. group 2 (p = .001), group 1 vs. group 3 (p = .003), and group 1 vs. group 4 (p = .048). Vitamin D‐fortified yogurt had the largest effect size on the serum level of vitamin D and it showed a significant difference with RY (p = .018) and PY (p = .002). Consumption of vitamin D‐fortified yogurt and PY could be regarded as a promising approach during calorie restriction.

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Efficacy of parsley seed-supplemented bread in improving serum osteopontin level and renal health in obese women: A nutritional intervention study

Essa,

El Shebini,

Moaty

et al. 2024

Clinical Nutrition ESPEN

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The Weight of Vitamin D on Obesity Outcomes: What Do We Know?

Cited by 5 publications

References 21 publications

Relationship Between Hypovitaminosis D and Fractures Among Adolescents With Overweight or Obesity

Relationship Between Hypovitaminosis D and Fractures Among Adolescents With Overweight or Obesity

Consumption of probiotic yogurt and vitamin D‐fortified yogurt increases fasting level of GLP‐1 in obese adults undergoing low‐calorie diet: A double‐blind randomized controlled trial

Efficacy of parsley seed-supplemented bread in improving serum osteopontin level and renal health in obese women: A nutritional intervention study

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