Let [Formula: see text] be a finite measure space and consider a Banach function space [Formula: see text]. Motivated by some previous papers and current applications, we provide a general framework for representing reproducing kernel Hilbert spaces as subsets of Köthe–Bochner (vector-valued) function spaces. We analyze operator-valued kernels [Formula: see text] that define integration maps [Formula: see text] between Köthe–Bochner spaces of Hilbert-valued functions [Formula: see text] We show a reduction procedure which allows to find a factorization of the corresponding kernel operator through weighted Bochner spaces [Formula: see text] and [Formula: see text] — where [Formula: see text] — under the assumption of [Formula: see text]-concavity of [Formula: see text] Equivalently, a new kernel obtained by multiplying [Formula: see text] by scalar functions can be given in such a way that the kernel operator is defined from [Formula: see text] to [Formula: see text] in a natural way. As an application, we prove a new version of Mercer Theorem for matrix-valued weighted kernels.