The waist-height ratio is a potential anthropometric index of insulin resistance: Observations based on oral glucose tolerance test in lean, normo-glycaemic, Asian Indian males from Southern India

Anoop, Shajith; K, Felix Jebasingh; Philip, Dona Maria; Kurian, Mathews Edatharayil; Mohan, Vivek; Finney, Geethanjali; Nicolaï, Thomas

doi:10.1016/j.cegh.2021.100762

Cited by 2 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, 92.5% of obese participants had IR, compared with only 7.5% of lean participants. Interestingly, insulin remained positively correlated with WtHR after controlling for BMI, emphasizing the latter as a promising anthropometric screening parameter indicative of IR [ 36 ], being a sensitive, inexpensive, non-invasive, simple-to-assess, and easy-to-calculate tool [ 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

The Association between Peptide Hormones with Obesity and Insulin Resistance Markers in Lean and Obese Individuals in the United Arab Emirates

et al. 2022

View full text Add to dashboard Cite

Peptide hormones play a crucial role in body weight and glucose homeostasis. In this study, we aimed to explore this association and recruited 43 obese and 31 age- and sex-matched lean participants. We assessed their body mass index (BMI), waist circumference (WC), waist-to-height ratio (WtHR), percentage body fat (PBF), fasting blood levels of peptide hormones (GLP-1, GLP-2, insulin, leptin, ghrelin, CCK, and PYY), fasting blood sugar (FBS), and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). We tested the associations between peptide hormones and markers of obesity and insulin resistance (IR) by using the Independent-Samples t-test and Mann-Whitney U test, partial correlation, and logistic regression. FBS, insulin, HOMA-IR, GLP-1, GLP-2, and leptin were significantly higher in the obese group; ghrelin and CCK were significantly higher in lean participants, and no difference was seen for PYY. Controlling for BMI, GLP-1 was positively correlated with WtHR, while ghrelin was inversely correlated with WtHR. GLP-1 was correlated with HOMA-IR. GLP-1 was associated with obesity and IR markers in the regression model. Our results show that obese and lean adults display significant differences in plasma peptide hormone levels. GLP-1 levels were independently associated with markers of obesity and IR. Restoring the appetite hormone balance in obesity may represent a potential therapeutic target.

show abstract

Section: Discussionmentioning

confidence: 99%

The Association between Peptide Hormones with Obesity and Insulin Resistance Markers in Lean and Obese Individuals in the United Arab Emirates

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In the current study, males had significantly higher WHR than females, which may be of clinical significance. WHR is a surrogate measure of central adiposity [50,51] and is positively associated with inflammation [52], oxidative stress [53], and insulin resistance [54][55][56]. We also found that males had significantly higher fed-state plasma insulin concentrations compared to females, which may signify greater insulin resistance in older males than females.…”

Section: Discussionmentioning

confidence: 53%

The Minimum Methionine Requirement for Adults Aged ≥60 Years Is the Same in Males and Females

Paoletti,

Pencharz,

Ball

et al. 2023

Nutrients

View full text Add to dashboard Cite

The minimum methionine requirement in the presence of excess dietary cysteine has not been determined in older adults. This study aimed to determine the minimum methionine requirement in healthy older adults using the indicator amino acid oxidation (IAAO) method. Fifteen healthy adults ≥ 60 years of age received seven methionine intakes (0 to 20 mg/kg/d) plus excess dietary cysteine (40 mg/kg/d). Oxidation of the indicator, L-[1-13C]phenylalanine (F13CO2), was used to estimate the mean minimum methionine requirement using a change-point mixed-effect model. There was no statistical difference between male and female requirement estimates, so the data were pooled to generate a mean of 5.1 mg/kg/d (Rm2 = 0.46, Rc2 = 0.77; p < 0.01; 95% CI: 3.67, 6.53 mg/kg/d). This is the first study to estimate the minimum methionine requirement in healthy older adults, which is the same between the sexes and as our lab’s previous estimate in young adults. The findings are relevant considering current recommendations for increased consumption of plant foods, which will help to establish the appropriate balance of methionine and cysteine intake required to satisfy the sulphur amino acid requirements of older adults.

show abstract

The waist-height ratio is a potential anthropometric index of insulin resistance: Observations based on oral glucose tolerance test in lean, normo-glycaemic, Asian Indian males from Southern India

Cited by 2 publications

References 23 publications

The Association between Peptide Hormones with Obesity and Insulin Resistance Markers in Lean and Obese Individuals in the United Arab Emirates

The Association between Peptide Hormones with Obesity and Insulin Resistance Markers in Lean and Obese Individuals in the United Arab Emirates

The Minimum Methionine Requirement for Adults Aged ≥60 Years Is the Same in Males and Females

Contact Info

Product

Resources

About