The Wada test in Austrian, Dutch, German, and Swiss epilepsy centers from 2000 to 2005: a review of 1421 procedures

Haag, Anja; Knake, Susanne; Hamer, Hajo M.; Boesebeck, F.; Freitag, H.; Schulz, Reinhard; Baum, Petra; Helmstaedter, C.; Wellmer, Jörg; Urbach, Horst; Hopp, Peter; Mayer, Thomas; Hufnagel, A.; Jokeit, Hennric; Lerche, Holger; Uttner, Ingo; Meencke, Heinz-Joachim; Meierkord, Hartmut; Pauli, E.; Runge, Uwe; Saar, Josef; Trinka, Eugen; Benke, Thomas; Vulliémoz, Serge; Wiegand, Gert; Stephani, Ulrich; Wieser, Heinz Gregor; Rating, D.; Werhahn, Konrad J.; Noachtar, Soheyl; Schulze-Bonhage, A.; Wagner, Kathrin; Alpherts, W.C.J.; Boas, W. van Emde; Rosenow, Felix

doi:10.1016/j.yebeh.2008.02.012

Cited by 59 publications

(35 citation statements)

References 31 publications

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“…While intracarotidal amobarbital tests had been the rule in the past, the indication for this test in patients with selective surgery which does not affect the language cortex appears no longer justified 30. In completely left dominant patients, more clearcut lateralisation dependent results can be expected.…”

Section: Discussionmentioning

confidence: 99%

Hippocampal resection length and memory outcome in selective epilepsy surgery

Helmstaedter

Roeske

Kaaden

et al. 2011

Journal of Neurology, Neurosurgery & Psychiatry

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The data indicate that in SAH, mesial resection length and resected volumes have no differential effect on seizure outcome. The findings on memory outcome are best explained by suggesting that hippocampal volumes take the degree of preoperative pathology into account whereas resection length does not. This suggests resection of non-pathological functional tissues as the basis for memory outcome after SAH.

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Section: Discussionmentioning

confidence: 99%

Hippocampal resection length and memory outcome in selective epilepsy surgery

Helmstaedter

Roeske

Kaaden

et al. 2011

Journal of Neurology, Neurosurgery & Psychiatry

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“…1 Unfortunately, few of these techniques are suitable for children due to their significant drawbacks. For instance, ESM and IAT are highly invasive procedures that carry the risk of severe complications, including stroke, hemorrhage, and infection (0.5% to 5% for ESM 2 and 1% to 11% for IAT 3,4 ). Furthermore, these invasive procedures require the patient to remain alert for language assessment, which is unfeasible in half of children with intractable epilepsy due to cognitive and behavioral problems.…”

Section: Introductionmentioning

confidence: 99%

Language mapping in children using resting-state functional connectivity: comparison with a task-based approach

Gallagher¹,

Tremblay²,

Vannasing³

2016

J. Biomed. Opt

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Abstract. Patients with brain tumor or refractory epilepsy may be candidates for neurosurgery. Presurgical evaluation often includes language investigation to prevent or reduce the risk of postsurgical language deficits. Current techniques involve significant limitations with pediatric populations. Recently, near-infrared spectroscopy (NIRS) has been shown to be a valuable neuroimaging technique for language localization in children. However, it typically requires the child to perform a task (task-based NIRS), which may constitute a significant limitation. Resting-state functional connectivity NIRS (fcNIRS) is an approach that can be used to identify language networks at rest. This study aims to assess the utility of fcNIRS in children by comparing fcNIRS to more conventional task-based NIRS for language mapping in 33 healthy participants: 25 children (ages 3 to 16) and 8 adults. Data were acquired at rest and during a language task. Results show very good concordance between both approaches for language localization (Dice similarity coefficient ¼ 0.81 AE 0.13) and hemispheric language dominance (kappa ¼ 0.86, p < 0.006). The fcNIRS technique may be a valuable tool for language mapping in clinical populations, including children and patients with cognitive and behavioral impairments. © The Authors.Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…in the rare conditions where it is still indicated, the results of the IAT still guide surgical interventions and the indication of additional, in part invasive diagnostic procedures (e.g. electrocortical stimulation via implanted electrodes or intraoperatively) [2,3,27]. Different from fTCD, fMRI and most other non-deactivating procedures which derive language dominance patterns from the relative contribution of both interacting hemispheres, IAT and transcranial magnetic stimulation (TMS) conclude language dominance from deactivation of the suggested language relevant hemisphere or brain region, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…In the context of epilepsy surgery the intracarotidal amobarbital test (IAT; also Wada test [1]) still represents the gold standard for determination of the language dominant hemisphere [2][3][4]. This procedure, however, is invasive and today it appears mainly indicated if brain surgery may directly affect suggested eloquent cortex subserving language function.…”

Section: Introductionmentioning

confidence: 99%

Menstrual cycle corrupts reliable and valid assessment of language dominance: Consequences for presurgical evaluation of patients with epilepsy

Helmstaedter

Jockwitz

2015

Seizure

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A high intraindividual variability of language dominance patterns is indicated in women when assessed repeatedly by fTCD. Menstrual cycle appeared to be the source of inconsistency. The finding challenges the use of non-deactivating methods for language dominance assessment in epilepsy. Support for this is demonstrated with a female patient with epilepsy in whom language dominance assessed by repeated fMRI and fTCD varied concordantly with cycle but not so the repeated intracarotidal amobarbital test.

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The Wada test in Austrian, Dutch, German, and Swiss epilepsy centers from 2000 to 2005: a review of 1421 procedures

Cited by 59 publications

References 31 publications

Hippocampal resection length and memory outcome in selective epilepsy surgery

Hippocampal resection length and memory outcome in selective epilepsy surgery

Language mapping in children using resting-state functional connectivity: comparison with a task-based approach

Menstrual cycle corrupts reliable and valid assessment of language dominance: Consequences for presurgical evaluation of patients with epilepsy

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