The volumes of some compartment systems with sampling and loss from one compartment

On the Volume of Distribution at Steady State and Its Relationship With Two‐Compartmental Models

“…The standard ‘noncompartmental’11 expressions for clearance and volume of distribution at steady state are often thought to be model independent. However, over the past 3 decades12–14 and more recently15 it has been argued that this is not so. The ‘apparent’ volume of distribution is based upon the assumption that elimination of a compound is from the same compartment as that being observed.…”

A Diffusion Approximation Analysis of a General n-Compartment System.

“…Stochastic compar tment analysis has undergone rapid development for several years , and might be categorized as follows . First , many papers have emphasized the mathematical formulation and exploration of the stochastic behavior of a variety of compartment models; papers of this type are exemplified by Bright (1973) , Matis (1972Matis ( , 1974Matis ( , 1975aMatis ( , 1975b , Marcus (1975), Hartley (1972), Purdue (l974a , l974b , 1975) , Rescigno (1973) , Rubinow and Winzer (1971) 'S…”