Abstract:Mechanical ventilation (MV), a life-saving intervention for critically ill patients with respiratory failure caused by acute lung injury (ALI), can cause an inflammatory response in both diseased and normal lungs. MV itself can also cause ventilator-induced lung injury (VILI), a form of ALI [1]. VILI results not only from barotraumas caused by alveolar disruption, capillary leakage, or lung edema, but also from biotraumas caused by the secretion of pro-inflammatory cytokines and mediators in pulmonary cells
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