Recent critiques voiced by students in both the Global South and North has turned attention to the ways in which higher education practices have been informed by, and continue to perpetuate, a series of assumptions that favour particular epistemological perspectives. Across the world, students have criticized universities for the content of their curricula and for their institutional cultures and pedagogic practices that perpetuate the attainment gap and exclusion. In response, curriculum and pedagogic change is being debated and promoted on campuses. This introductory article lays the theoretical groundwork for a special issue that brings decolonial theory into concrete engagement with the structural, cultural, institutional, relational and personal logics of curriculum and pedagogic practice. The article examines the relationship between decolonization as a theoretical concept, and the practices of decoloniality unfolding in pedagogical practice.