The VLPFC versus the DLPFC in Downregulating Social Pain Using Reappraisal and Distraction Strategies

Zhao, Jun; Mo, Licheng; Rong, Bi; He, Zhenhong; Chen, Yuming; Xu, Feng; Xie, Hui; Zhang, Dandan

doi:10.1523/jneurosci.1906-20.2020

Cited by 63 publications

(105 citation statements)

References 83 publications

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“…Participants living in higher ADI areas had greater bilateral anterior insula connectivity with the vlPFC, a section of the PFC thought to underlie affect appraisal and emotion regulation ( Benelli et al, 2012 ; Prater et al, 2013 ; Zhao et al, 2021 ). Both the anterior insula and vlPFC are key nodes in the emotional salience network, an intrinsic connectivity network that is present during rest and anti-correlated with the default mode network ( Chai et al, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

Neural impact of neighborhood socioeconomic disadvantage in traumatically injured adults

Webb

Weis

Huggins

et al. 2021

Neurobiology of Stress

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Nearly 14 percent of Americans live in a socioeconomically disadvantaged neighborhood. Lower individual socioeconomic position (iSEP) has been linked to increased exposure to trauma and stress, as well as to alterations in brain structure and function; however, the neural effects of neighborhood SEP (nSEP) factors, such as neighborhood disadvantage, are unclear. Using a multi-modal approach with participants who recently experienced a traumatic injury ( N = 185), we investigated the impact of neighborhood disadvantage, acute post-traumatic stress symptoms, and iSEP on brain structure and functional connectivity at rest. After controlling for iSEP, demographic variables, and acute PTSD symptoms, nSEP was associated with decreased volume and alterations of resting-state functional connectivity in structures implicated in affective processing, including the insula, ventromedial prefrontal cortex, amygdala, and hippocampus. Even in individuals who have recently experienced a traumatic injury, and after accounting for iSEP, the impact of living in a disadvantaged neighborhood is apparent, particularly in brain regions critical for experiencing and regulating emotion. These results should inform future research investigating how various levels of socioeconomic circumstances may impact recovery after a traumatic injury as well as policies and community-developed interventions aimed at reducing the impact of socioeconomic stressors.

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Section: Discussionmentioning

confidence: 99%

Neural impact of neighborhood socioeconomic disadvantage in traumatically injured adults

Webb

Weis

Huggins

et al. 2021

Neurobiology of Stress

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“…These comparisons, however, did not encompass direct comparison within studies and failed to show a statistically significant difference. The causal role of the vlPFC in specific is supported by experimental TMS studies that demonstrated a facilitation of reappraisal after vlPFC stimulation (48,49). In a similar vein, transcranial direct current stimulation (tDCS) of the vlPFC may influence emotion regulation.…”

Section: Introductionmentioning

confidence: 98%

fMRI Neurofeedback-Enhanced Cognitive Reappraisal Training in Depression: A Double-Blind Comparison of Left and Right vlPFC Regulation

et al. 2021

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Affective disorders are associated with maladaptive emotion regulation strategies. In particular, the left more than the right ventrolateral prefrontal cortex (vlPFC) may insufficiently regulate emotion processing, e.g., in the amygdala. A double-blind cross-over study investigated NF-supported cognitive reappraisal training in major depression (n = 42) and age- and gender-matched controls (n = 39). In a randomized order, participants trained to upregulate either the left or the right vlPFC during cognitive reappraisal of negative images on two separate days. We wanted to confirm regional specific NF effects with improved learning for left compared to right vlPFC (ClinicalTrials.gov NCT03183947). Brain responses and connectivity were studied with respect to training progress, gender, and clinical outcomes in a 4-week follow-up. Increase of vlPFC activity was stronger after NF training from the left- than the right-hemispheric ROI. This regional-specific NF effect during cognitive reappraisal was present across patients with depression and controls and supports a central role of the left vlPFC for cognitive reappraisal. Further, the activity in the left target region was associated with increased use of cognitive reappraisal strategies (r = 0.48). In the 4-week follow-up, 75% of patients with depression reported a successful application of learned strategies in everyday life and 55% a clinically meaningful symptom improvement suggesting clinical usability.

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“…26 volunteers participated in the study (mean age 25.4, SD 3.5; 15 females, 10 males, 1 other gender). A similar sample size was used in previous studies that investigated the effect of TMS stimulation on emotion regulation 29 . Data from two subjects were discarded due to technical malfunctions during recording.…”

Section: Participantsmentioning

confidence: 99%

“…Only VLPFC stimulation resulted in a decrease of self-reported negativity of reappraised emotional pictures along with changes in cardiac reactivity measured by interbeat interval (IBI). In another experiment, the right DLPFC and VLPFC regions were stimulated using an offline 10Hz excitatory repetitive TMS (rTMS) protocol before participants were asked to use reappraisal to down-regulate their emotional responses to affective social stimuli 29 . The modulatory effects were quantified using the late positive potential (LPP; an ERP marker of the depth of emotional responses) and self-report scores.…”

Section: Introductionmentioning

confidence: 99%

Offline rTMS inhibition of the bilateral dorsolateral prefrontal cortex impairs reappraisal efficacy

Wyczesany

Adamczyk

Hobot

et al. 2022

Preprint

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In the study we verified the causal role of the dorsolateral prefrontal cortex in performing reappraisal strategy of emotional control. Subjects underwent three sessions of inhibitory offline theta burst TMS stimulation that was targeted at either left dorsolateral, right dorsolateral or vertex area. During the experimental task they were asked to either passively watch or reappraise affective pictures. Efficacy of emotional control was quantified using the late positivity potential of the evoked brain responses. After both left and right dorsolateral stimulation, reappraisal was compromised compared to the vertex session. Worsening of affective control was reflected in earlier but not later time windows of the late positivity. It is suggested that inhibitory stimulation primarily affected top-down mechanism of attentional deployment necessary to focus on the content of experimental stimuli that enables elaboration of new, less negative interpretation of emotional content.

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The VLPFC versus the DLPFC in Downregulating Social Pain Using Reappraisal and Distraction Strategies

Cited by 63 publications

References 83 publications

Neural impact of neighborhood socioeconomic disadvantage in traumatically injured adults

Neural impact of neighborhood socioeconomic disadvantage in traumatically injured adults

fMRI Neurofeedback-Enhanced Cognitive Reappraisal Training in Depression: A Double-Blind Comparison of Left and Right vlPFC Regulation

Offline rTMS inhibition of the bilateral dorsolateral prefrontal cortex impairs reappraisal efficacy

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