The Vitreo-Retinopathy Associated with Retinal Detachment Among Africans

Av-Shalom, A.; Berson, David M.; Gombos, George M.; Landau, Louis I.; Michaelson, I. C.; Zauberman, H

doi:10.1016/0002-9394(67)92001-6

Cited by 10 publications

(2 citation statements)

References 7 publications

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“…Previous reference to racial differences in the vitreoretinal interface (VRI) was made by Av-Shalom [ 54 ] who suggested that degenerative vitreous changes were rare in Africans compared to Caucasians. To the best of our knowledge, only one report exists on VMI changes and potential associations with AMD in the north-eastern African population, from Egypt [ 3 ], which found no association between VMA and AMD [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Vitreomacular interface abnormalities in the Ghanaian African

Amoaku,

Cushley,

Silvestri

et al. 2023

Eye

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Background/Objective Describe vitreomacular interface abnormalities (VMIA) using spectral-domain optical coherence tomography (SD-OCT), and correlations with age-related macular degeneration (AMD) grade in Ghanaian Africans. Subjects/Methods Prospective, cross-sectional study of adults aged ≥50 years recruited in Ghana AMD Study. Participant demographics, medical histories, ophthalmic examination, digital colour fundus photography (CFP) were obtained. High-resolution five-line raster OCT, Macular Cube 512 × 128 scans, and additional line scans in areas of clinical abnormality, were acquired. SD-OCT VMI features classified by International Vitreomacular Traction Study Group system and relationships to AMD grade were evaluated. Outcomes: VMIA prevalence, posterior vitreous detachment (PVD), vitreomacular adhesions (VMA), vitreomacular traction (VMT), epiretinal membranes (ERM), correlations with AMD grade. Results The full Ghana AMD cohort included 718 participants; 624 participants (1248 eyes) aged ≥50 years (range = 50–101, mean = 68.8), 68.9% female were included in this analysis. CFP with OCT scans were available for 776 eyes (397 participants); 707 (91.1%) had gradable CFP and OCT scans for both AMD and VMI grading forming the dataset for this report. PVD was absent in 504 (71.3%); partial and complete PVD occurred in 16.7% and 12.0% respectively. PVD did not increase with age (p = 0.720). VMIA without traction and macular holes were observed in 12.2% of eyes; 87.8% had no abnormalities. VMIA was not significantly correlated with AMD grade (p = 0.819). Conclusions This provides the first assessment of VMIA in Ghanaian Africans. VMIA are common in Africans; PVD may be less common than in Caucasians. There was no significant association of AMD grade with VMIA.

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Section: Introductionmentioning

confidence: 99%

Vitreomacular interface abnormalities in the Ghanaian African

Amoaku,

Cushley,

Silvestri

et al. 2023

Eye

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“…There is no statistically significant difference in prevalence between men and women, and left and right eyes are involved with equal frequency [2], [3]. The prevalence of lattice degeneration of the retina is not related to race, and it has been reported to be common in Caucasians [2], Asians [5], [6], and Africans [7]. Although the etiology of familial retinal detachment associated with lattice degeneration is thought to be polygenic and/or multifactorial [8], the pathophysiological mechanism and underlying genetic factors remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Common Variants in the COL4A4 Gene Confer Susceptibility to Lattice Degeneration of the Retina

et al. 2012

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Lattice degeneration of the retina is a vitreoretinal disorder characterized by a visible fundus lesion predisposing the patient to retinal tears and detachment. The etiology of this degeneration is still uncertain, but it is likely that both genetic and environmental factors play important roles in its development. To identify genetic susceptibility regions for lattice degeneration of the retina, we performed a genome-wide association study (GWAS) using a dense panel of 23,465 microsatellite markers covering the entire human genome. This GWAS in a Japanese cohort (294 patients with lattice degeneration and 294 controls) led to the identification of one microsatellite locus, D2S0276i, in the collagen type IV alpha 4 (COL4A4) gene on chromosome 2q36.3. To validate the significance of this observation, we evaluated the D2S0276i region in the GWAS cohort and in an independent Japanese cohort (280 patients and 314 controls) using D2S0276i and 47 single nucleotide polymorphisms covering the region. The strong associations were observed in D2S0276i and rs7558081 in the COL4A4 gene (Pc = 5.8×10−6, OR = 0.63 and Pc = 1.0×10−5, OR = 0.69 in a total of 574 patients and 608 controls, respectively). Our findings suggest that variants in the COL4A4 gene may contribute to the development of lattice degeneration of the retina.

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Lattice Degeneration in the Black African

Knobloch

1979

Progress in Anterior Eye Segment Research and Practice

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The Vitreo-Retinopathy Associated with Retinal Detachment Among Africans

Cited by 10 publications

References 7 publications

Vitreomacular interface abnormalities in the Ghanaian African

Vitreomacular interface abnormalities in the Ghanaian African

Common Variants in the COL4A4 Gene Confer Susceptibility to Lattice Degeneration of the Retina

Lattice Degeneration in the Black African

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