The Vitiligo Working Group recommendations for narrowband ultraviolet B light phototherapy treatment of vitiligo

Mohammad, Tasneem F.; Al‐Jamal, Mohammed; Hamzavi, Iltefat; Harris, John E.; Leone, Giovanni; Cabrera, Raúl; Lim, Henry W.; Pandya, Amit G.; Esmat, Samia

doi:10.1016/j.jaad.2016.12.041

Cited by 86 publications

(130 citation statements)

References 18 publications

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“…However, long‐term studies to date do not indicate a significantly increased risk of skin cancer over an age‐ and sex‐matched control population, who have not received UVB phototherapy. NB‐UVB phototherapy is a safe therapy (Thompson & Kim, ; Ibbotson, ; Mohammad et al, ). We report this case in the hope that NBUVB will be an option for intractable verruca plana, because the treatment is simple and easy, the duration is not long, no obvious adverse reactions (especially scars).…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of verruca plana with NB‐UVB: A case report

Zhang

Ren

et al. 2020

Dermatologic Therapy

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Verruca plana is a kind of benign proliferative skin disease that generally occurs in exposed parts, but the treatment of warts poses a therapeutic challenge for physicians, as there is no method, among numerous approaches, that has been proven effective for completely curing this disease. We report a case of verruca plana cured by narrow‐band ultraviolet B (NB‐UVB), which provides a new treatment of verruca plana.

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Section: Discussionmentioning

confidence: 99%

Successful treatment of verruca plana with NB‐UVB: A case report

Zhang

Ren

et al. 2020

Dermatologic Therapy

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“…Demographic information, vitiligo type, starting dose, peak dose without subsequent phototoxic events, frequency of phototherapy, total number of phototoxic events, and total number of phototherapy treatments were extracted from charts. NBUVB phototherapy regimens had been individualized to the patient using the vitiligo phototherapy protocol set forth by the Vitiligo Working Group . Patient charts were also reviewed for the presence of photosensitizing disorders and use of concomitant photosensitizing medications in association with phototoxic events.…”

Section: Methodsmentioning

confidence: 99%

“…Segmental vitiligo tends to be less responsive to medical treatments and phototherapy, whereas generalized vitiligo tends to be more responsive to medical treatments and phototherapy. Narrowband‐ultraviolet B (NBUVB, 311‐313 nm) phototherapy is currently the mainstay of phototherapy in patients with generalized vitiligo and can be used to treat localized vitiligo (excimer laser) …”

Section: Introductionmentioning

confidence: 99%

“…NBUVB phototherapy guidelines were recently published by the Vitiligo Working Group. Although there is mention of two institutions that include testing for ANA positivity in their NBUVB phototherapy protocols (one of which is Henry Ford Hospital), there remains a lack of unified consensus on appropriateness of checking for ANA positivity in patients with vitiligo . At our institution, evaluation of serum ANA is performed specifically in patients who are identified as non‐photoadapters …”

Section: Introductionmentioning

confidence: 99%

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The impact of positive antinuclear antibody on narrowband ultraviolet B phototherapy in patients with vitiligo: A retrospective chart review

Nahhas¹,

Nartker

Braunberger

et al. 2018

Photoderm Photoimm Photomed

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Summary Background/Purpose Screening antinuclear antibody (ANA) is not recommended prior to initiating narrowband ultraviolet B (NBUVB) phototherapy in vitiligo patients, unless concern for photosensitivity exists. Guidelines on prescribing NBUVB phototherapy in vitiligo patients with positive ANA are unavailable, prompting this study to uncover trends. Methods This retrospective chart review investigated patients 12 years of age or older with a diagnosis of vitiligo between January 2015 and September 2017, positive serum ANA, and NBUVB phototherapy. Demographic information, vitiligo type, ANA titer/pattern, starting dose, peak dose without phototoxicity, phototherapy frequency, total number of phototoxic events and treatments, coexisting photosensitizing disorders, and concomitant photosensitizing medications were collected. Results Seven (two males, five females) of 1485 charts met inclusion criteria. One Caucasian, two African‐Americans, one Asian, and three Hispanic/Latinos patients were represented. Six of seven patients had generalized vitiligo and one had focal vitiligo. ANA titer/patterns and phototherapy frequencies were evaluated. Peak doses of NBUVB without phototoxic event were available in six of seven patients: 274, 290, 532, 618, 700, and 734 mJ/cm2. Total number of phototoxic events varied: 1 (n = 1), 2 (n = 1), 4 (n = 1), 6 (n = 2), or 8 (n = 1). Total NBUVB treatments ranged between 6 and 132. Coexisting photosensitizing disorders were not identified. One patient had phototoxic events in association with photosensitizing medications. Conclusion With regard to phototoxicity, meaningful trends were not identified that may guide prescription of phototherapy in vitiligo patients with positive ANA, suggesting ANA may not be exclusionary criteria when prescribing NBUVB.

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“…Although institutions have individual guidelines on the administration of NB‐UVB phototherapy in vitiligo, no uniformly published guidelines exist. To address this gap, the Vitiligo Working Group developed phototherapy recommendations, which have recently been published (Table ) …”

Section: Nb‐uvb Phototherapymentioning

confidence: 99%

Home phototherapy in vitiligo

Mohammad

Silpa‐archa

Griffith

et al. 2017

Photoderm Photoimm Photomed

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SummaryVitiligo is a disorder characterized by the development of depigmented macules and patches. Narrowband ultraviolet B phototherapy is a standard of care treatment and is used both as monotherapy and in combination with other treatment modalities to induce repigmentation. Although phototherapy is safe and effective, its use is limited due to the significant time commitment required and associated costs. Home phototherapy is a safe and effective alternative to make phototherapy more accessible to patients. However, it is often underutilized due to lack of physician experience and comfort as well as misconceptions regarding its safety and efficacy. This article provides a brief overview of the use of phototherapy in vitiligo with a focus on home phototherapy in order to increase awareness and use of this treatment modality. K E Y W O R D Shome phototherapy, narrowband ultraviolet B, phototherapy, pigmentation, vitiligo

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The Vitiligo Working Group recommendations for narrowband ultraviolet B light phototherapy treatment of vitiligo

Cited by 86 publications

References 18 publications

Successful treatment of verruca plana with NB‐UVB: A case report

Successful treatment of verruca plana with NB‐UVB: A case report

The impact of positive antinuclear antibody on narrowband ultraviolet B phototherapy in patients with vitiligo: A retrospective chart review

Home phototherapy in vitiligo

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