The Vitamin D Status Among Tibetans

Gelsor, Norsang; Ma, Liang; Dahlback, Arne; Zhuoma, Ciren; Wangmo, Tsoja; Porojnicu, Alina Carmen; Lagunova, Zoya; Moan, Johan Emelian

doi:10.1111/j.1751-1097.2009.00552.x

Cited by 20 publications

(23 citation statements)

References 21 publications

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“…In agreement with our previous article [19], there is a great difference in levels We have tested the 25(OH)D level in different gender. The data of Figure 6 (the average group is the mean value of the Lhasa, Shigatse, Tingri, Nagqu)…”

Section: Resultssupporting

confidence: 62%

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Human Vitamin D Deficiency in Tibet

Gelsor¹,

Ma²,

Duan³

et al. 2017

FNS

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Vitamin D contributes significantly to human bone formation, growth, metabolism and disease prevention. During 2007During -2009During and 2012During -2013, we measured serum calcidiol (25-hydroxyvitamin D3, 25-(OH)D) in Lhasa, Shigatse, Tingri, Nagqu and other places of Tibet in order to get the status of the overall level of vitamin D in Tibet. We also studied influence of area, occupation, age, gender, season and other factors on the serum 25(OH)D level. Results of our study indicate that: 1) in Tibet, the overall serum concentration of calcidiol is in deficiency range (25(OH)D level is 12.25 ng/ml); 2) the serum level of 25(OH)D in different regions is generally the same; 3) the serum level of 25(OH)D in young and middle-aged people is 20% higher than that in elder; 4) the level of 25(OH)D in male is slightly higher than in female; 5) the level of 25(OH)D in summer is significantly higher than that in winter; 6) there are obvious differences in serum level of 25(OH)D among tested subjects with different occupations.

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Section: Resultssupporting

confidence: 62%

“…A standard radioimmune assay was employed to determine the serum concentrations of 25(OH)D [19]. Nagqu (11.5 ± 4.9 ng/mL), Shigatse (11.9 ± 4.7 ng/mL) and Tingri (13.4 ± 6.5 ng/mL) during 2012 and 2013.…”

Section: Methodsmentioning

confidence: 99%

Human Vitamin D Deficiency in Tibet

Gelsor¹,

Ma²,

Duan³

et al. 2017

FNS

Self Cite

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“…Most human studies have observed an important correlation between sun exposure and vitamin D levels accounting for more than 50% of changes in vitamin D status (25,45). Ultraviolet B light exposure is increased at higher altitude; however, several studies have shown significant vitamin D deficiency in humans, including pregnant women, living in high-altitude locations (2,34,37). In addition to vitamin D deficiency, high-altitude residents are exposed to hypobaric hypoxia, a major risk factor for pregnancy complications.…”

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confidence: 99%

Vitamin D status and metabolism in an ovine pregnancy model: effect of long-term, high-altitude hypoxia

Goyal

Billings²,

Mansour³

et al. 2016

American Journal of Physiology-Endocrinology and Metabolism

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Vitamin D status increases during healthy mammalian pregnancy, but the molecular determinants remain uncharacterized. The first objective of this study was to determine the effects of pregnancy, and the second objective was to examine the role of chronic hypoxia on vitamin D status and metabolism in an ovine model. We analyzed the plasma levels of cholecalciferol, 25-OH-D, and 1␣,25-(OH)2D in nonpregnant ewes, near-term pregnant ewes, and their fetuses exposed to normoxia (low altitude) or hypoxia (high-altitude) for 100 days. Hypoxic sheep had increased circulating levels of 25-OH-D and 1␣,25-(OH)2D compared with normoxic sheep. Hypoxia increases in 25-OH-D were associated with increased expression of renal 25-hydroxylases CYP2R1 and CYP2J. Pregnancy did not increase further the plasma levels of 25-OH-D, but it significantly increased those of the active metabolite, 1␣,25-(OH)2D, in both normoxic and hypoxic ewes. Increased bioactivation of vitamin D correlated with increased expression of the vitamin D-activating enzyme CYP27b1 and decreased expression of the inactivating enzyme CYP24a1 in maternal kidneys and placentas. Hypoxia increased parathyroid hormone levels and further increased renal CYP27b1. Pregnancy and hypoxia decreased the expression of vitamin D receptor (VDR) in maternal kidney and lung, with opposite effects on placental VDR. We conclude that ovine pregnancy is a model of increased vitamin D status, and long-term hypoxia further improves vitamin D status due to pregnancy-and hypoxia-specific regulation of VDR and metabolic enzymes.pregnancy; hypoxia; vitamin D; metabolism; kidney; placenta VITAMIN D HAS WELL-ESTABLISHED CLASSIC EFFECTS on bone metabolism and mineral homeostasis (8,33). In addition, vitamin D has important noncalcemic roles in the reproductive, cardiovascular, renal, lung, immune, neuronal, and pancreatic systems (8, 33). In reproduction, vitamin D deficiency has been associated with sterility, placental insufficiency, intrauterine growth restriction, recurrent miscarriages, gestational diabetes, and preeclampsia (maternal high blood pressure and proteinuria) (6, 51-53). Furthermore, maternal vitamin D deficiency has been also linked to postnatal infectious diseases, autoimmune diseases (diabetes type I), asthma, and obesity (26,28,54).Vitamin D 3 (cholecalciferol) can be produced endogenously from 7-dehydrocholesterol by sun exposure in the skin epidermis or obtained from dietary sources (8,33 (14). A classic gene regulated in this manner is the vitamin D-inactivating enzyme CYP24A1 (24-hydroxylase). Most cells that express VDR also express CYP24A1, providing a unique negative feedback control mechanism to regulate the vitamin D effects (8,14). In healthy nonpregnant mammals, the circulating levels of 1␣,25-(OH) 2 D are tightly regulated; low levels of 1␣,25-(OH) 2 D stimulate the release of parathyroid hormone (PTH) that upregulates renal CYP27b1 expression, and high levels of 1␣,25-(OH) 2 D stimulates VDR that upregulates CYP24a1 expression (8, 33).The metabolism of vitamin ...

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“…Research covering topics from its effectiveness to its ability to integrate with western medicine has begun to develop both in Tibetan regions and the west [12][13][14][15][16][17][18][19][20]. This research is a good start but to often lacks more rigorous scientific investigations.…”

Section: Future Developmentsmentioning

confidence: 99%

Tibetan medicine: a unique heritage of person-centered medicine

Sarsina

Ottaviani²,

Mella

2011

EPMA Journal

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With a history going back approximately 2,500 years, the Tibetan medicine, known as Sowa Rigpa in the Tibetan language, is one of the world's oldest known traditional medicine. It originally developed during the preBuddhist era in the kingdom known as Shang Shung. As a traditional medicine, the future development of Tibetan medicine in Western countries is linked to being recognized as a popular and viable healthcare option providing an alternative clinical reality. Its inherent ability to incorparate predictive diagnostics, targeted prevention, and the creation of individualized medical treatment give Tibetan medicine great potential for assessing and treating patients.

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The Vitamin D Status Among Tibetans

Cited by 20 publications

References 21 publications

Human Vitamin D Deficiency in Tibet

Human Vitamin D Deficiency in Tibet

Vitamin D status and metabolism in an ovine pregnancy model: effect of long-term, high-altitude hypoxia

Tibetan medicine: a unique heritage of person-centered medicine

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