The vitamin D metabolites 25(OH)D and 1,25(OH)2D are not related to either glucose metabolism or insulin action in obese women

Horst, Kasper W. ter; Versteeg, Ruth I.; Gilijamse, Pim W.; Ackermans, Mariëtte T.; Heijboer, Annemieke C.; Romijn, Johannes A.; Fleur, Susanne E. la; Trinko, Richard; DiLeone, Ralph J.; Serlie, Mireille J.

doi:10.1016/j.diabet.2016.04.011

Cited by 8 publications

(7 citation statements)

References 41 publications

(54 reference statements)

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“…This observation in the underweight group might be explained by the ability of vitamin D to decrease glucose utilization as a substrate for fatty acid synthesis in the adipose tissue 38,39 . The present findings on the lack of association between levels of vitamin D and HbA1c in obese individuals are consistent with those of other investigators 49,50 . Ter Horst et al 50 found no association between the levels of vitamin D metabolites and glucose metabolism or insulin action in obese women.…”

Section: And Decreasedsupporting

confidence: 93%

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Vitamin D levels, prediabetes risk and hemoglobin A1c levels in young non‐diabetic Saudi women

Al-Mohaissen

Lee

Alamri

2020

J of Diabetes Invest

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Aims/Introduction Vitamin D levels are negatively correlated with prediabetes risk and hemoglobin A1c levels in individuals with prediabetes. The data are, however, scarce and inconsistent among different populations. We aimed to assess the association of vitamin D with prediabetes risk and hemoglobin A1c levels in young Saudi women with normoglycemia and prediabetes. Materials and Methods We analyzed the data of individuals without diabetes (without diabetes history and hemoglobin A1c <6.4%) from the Princess Nourah bint Abdulrahman University’s non‐communicable diseases student registry. Demographic data, anthropometric and blood pressure measurements, and hemoglobin A1c and vitamin D results were retrieved and analyzed. Results In total, 345 participants were included in the analysis. The prediabetes status showed no association with vitamin D levels, but it was significantly associated with the participants’ weight and body mass index. Additionally, there was no correlation between the levels of vitamin D and hemoglobin A1c across the whole population, even after correction for body mass index. However, in the body mass index subgroups, when individuals with potentially harmful levels of vitamin D (>125 nmol/L) were excluded, a positive association was detected between vitamin D and hemoglobin A1c levels in the underweight individuals. Hemoglobin A1c values showed a positive correlation only with bodyweight and body mass index. Conclusions Vitamin D levels did not predict prediabetes status and showed no correlation with hemoglobin A1c levels in this population. Vitamin D levels’ effect on the risk of prediabetes might be small compared with other well‐established risk factors, such as obesity.

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Section: And Decreasedsupporting

confidence: 93%

“…The present findings on the lack of association between levels of vitamin D and HbA1c in obese individuals are consistent with those of other investigators 49,50 . Ter Horst et al 50 found no association between the levels of vitamin D metabolites and glucose metabolism or insulin action in obese women.…”

Section: And Decreasedsupporting

confidence: 93%

Vitamin D levels, prediabetes risk and hemoglobin A1c levels in young non‐diabetic Saudi women

Al-Mohaissen

Lee

Alamri

2020

J of Diabetes Invest

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“…Here, the lack of correlation between 25(OH)D and glucose metabolism markers and the presence of a trend towards a negative correlation between the categories of serum 25(OH)D deficiency and overweight/obesity status point to a link with overweight/obesity rather than with T2DM. Likewise, Horst et al [ 21 ] reported no association between 25(OH)D deficiency and impaired glucose metabolism in morbidly obese women, but rather, with BMI and total body fat. On the other hand, Clemente-Postigo et al [ 17 ] showed that 25(OH)D levels are diminished, but mostly in relation to carbohydrate metabolism, i.e., to T2DM rather than obesity.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, while some findings show a negative correlation between vitamin D and IR [ 16 , 17 ], others do not [ 18 , 19 ]. Also, some authors claim that vitamin D deficiency seems to be more related to glucose metabolism than to obesity [ 17 ] whereas others argue that the shortage is more associated with the degree of adiposity instead [ 20 ], suggesting that vitamin D does not play an important role in obesity-associated IR [ 21 ]. Furthermore, other authors [ 22 ] have suggested that the association between plasma 25(OH)D deficiency and IR in overweight and obese adults seems to be driven by central adiposity.…”

Section: Introductionmentioning

confidence: 99%

Relationship between 25 Hydroxyvitamin D, Overweight/Obesity Status, Pro-Inflammatory and Oxidative Stress Markers in Patients with Type 2 Diabetes: A Simplified Empirical Path Model

et al. 2021

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Vitamin D deficiency is highly prevalent in patients with overweight/obesity and type 2 diabetes (T2DM). Herein, we investigated the relationship between vitamin D status and overweight/obesity status, insulin resistance (IR), systemic inflammation as well as oxidative stress (OS). Anthropometric and laboratory assessments of 25-hydroxyvitamin D (25(OH)D) and glycemic, pro-inflammatory and OS biomarkers were performed in a sample of 47 patients with T2DM who were divided into categories based on overweight and degree of obesity. The main findings were: the overweight/obesity status correlated negatively with the degree of serum 25(OH)D deficiency (ρ = −0.27) with a trend towards statistical significance (p = 0.069); the homeostasis model assessment of insulin resistance (HOMA-IR) was significantly different (p = 0.024) in patients with 25(OH)D deficiency, as was total oxidant status (TOS) and oxidative stress index (OSI) in patients with severe serum 25(OH)D deficiency as compared to those with 25(OH)D over 20 ng/mL (TOS: p = 0.007, OSI: p = 0.008); and 25(OH)D had a negative indirect effect on TOS by body mass index (BMI), but BMI was not a significant mediator of the studied relationship. In a setting of overweight and increasing degree of obesity, patients with T2DM did not display decreasing values of 25(OH)D. Subjects with the lowest values of 25(OH)D presented the highest values of BMI. Patients with 25(OH)D deficiency were more insulin resistant and showed increased OS but no elevated systemic inflammation. The negative effect of 25(OH)D on TOS did not seem to involve BMI as a mediator.

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“…There was a steady state at baseline as well as during ISO so that pooling was justified. Vitamin D metabolites were analyzed using liquid-chromatography tandem-mass spectrophotometry (LC-MS/MS) (Ter Horst et al, 2016). Stable isotope enrichment of glycerol was measured using GC-MS as described previously (Jocken et al, 2008).…”

Section: Laboratory Analysismentioning

confidence: 99%

Vitamin D release across abdominal adipose tissue in lean and obese men: The effect of ß‐adrenergic stimulation

et al. 2019

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Obesity is characterized by a blunted lipolytic response in abdominal subcutaneous adipose tissue (SAT) and low circulating vitamin D levels. Here we investigated whether an impaired SAT lipolytic response coincides with an impaired SAT vitamin D release in eight lean and six obese men. 25‐hydroxyvitamin D3 [25(OH)D3] and 1,25‐dihydroxyvitamin D3 [1,25(OH)2D3] fluxes across SAT were measured using arterio‐venous blood sampling in combination with AT blood flow measurements after an overnight fast and during 1‐hr intravenous infusion of the non‐selective ß‐adrenergic agonist isoprenaline (20 ng·kg FFM−1·min−1). 1,25(OH)2D3 was released across abdominal SAT during isoprenaline infusion in lean [−0.01 (−0.04 to 0.00) pmol*100 g tissue−1*min−1, p = .017 vs. zero flux], but not in obese men [0.01 (0.00 to 0.02) pmol*100 g tissue−1*min−1, p = .116 vs. zero flux], and accompanied by an impaired isoprenaline‐induced lipolytic response in abdominal SAT of obese versus lean men. Isoprenaline had no significant effects on net 25(OH)D3 release across abdominal SAT and plasma vitamin D metabolites in lean and obese men. To conclude, a blunted isoprenaline‐mediated lipolysis is accompanied by reduced release of 1,25(OH)2D3 vitamin D across abdominal SAT in obesity.

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The vitamin D metabolites 25(OH)D and 1,25(OH)2D are not related to either glucose metabolism or insulin action in obese women

Cited by 8 publications

References 41 publications

Vitamin D levels, prediabetes risk and hemoglobin A1c levels in young non‐diabetic Saudi women

Vitamin D levels, prediabetes risk and hemoglobin A1c levels in young non‐diabetic Saudi women

Relationship between 25 Hydroxyvitamin D, Overweight/Obesity Status, Pro-Inflammatory and Oxidative Stress Markers in Patients with Type 2 Diabetes: A Simplified Empirical Path Model

Vitamin D release across abdominal adipose tissue in lean and obese men: The effect of ß‐adrenergic stimulation

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