“…On 29 April 2013, the competent authorities of the United Kingdom forwarded to the Commission their initial assessment report, which came to the conclusion that this algal oil, at levels up to 3 000 mg EPA and DHA per day in food supplements and not exceeding the maximum use levels previously described for other foods, meets the criteria for acceptance of a novel food defined in Article (3) Although, overall, evidence from studies is inconsistent, a positive association between a) high intake levels and b) high plasma concentrations of DHA/EPA and the risk of high-grade prostatic intraepithelial neoplasia, a precursor of prostate cancer, has been found in some meta-analyses (Chua et al, 2012;Dahm et al, 2012;Chua et al, 2013;Sorongon-Legaspi et al, 2013). It was noted that a placebo-controlled, double-blind intervention study is in progress in the US which investigates the possibility of a link between intake of vitamin D (50 µg/day) and DHA/EPA (1 g/day) and the incidence of cancer and cardiovascular disease (Manson et al, 2012). (ACNFP, 2012;FSA, 2012).…”