The visfatin gene is associated with glucose and lipid metabolism in a Chinese population

Jian, Weixia; Luo, Ting; Gu, Yunjuan; Zhang, H.‐L.; Shao-xiong, Zheng; Dai, Meng; Han, Jing; Zhao, Ying; Li, G.; Luo, Mao

doi:10.1111/j.1464-5491.2006.01909.x

Cited by 81 publications

(75 citation statements)

References 24 publications

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“…Most of our patients with glucose metabolism abnormalities had prediabetes -IFG, IGT, or both. The lack of difference in visfatin concentration between two subgroups is consistent with the findings obtained by other authors who evaluated visfatin levels in individuals with prediabetes [18][19][20]. Dogru found no difference in the plasma levels of visfatin between non-obese patients with newly diagnosed diabetes and newly diagnosed impaired glucose tolerance, as well as between patients with impaired glucose tolerance and healthy controls.…”

Section: Rycina 3 Korelacja Pomiędzy Wisfatyną a Hba 1c W Grupie A supporting

confidence: 80%

“…Although conflicting results were obtained in different studies assessing correlations between visfatin and anthropometric parameters [16,19,29], there is evidence that plasma visfatin levels are largely determined by body weight, probably mainly by visceral adipose tissue [6]. A significant decrease in mean serum visfatin concentration was found in girls with anorexia nervosa, the disease that leads to significant reduction of adipose tissue mass [30].…”

Section: Rycina 3 Korelacja Pomiędzy Wisfatyną a Hba 1c W Grupie A mentioning

confidence: 99%

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Stężenie wisfatyny u osób z otyłością w zależności od obecności świeżo wykrytych zaburzeń gospodarki węglowodanowej

Kamińska

Kopczyńska

Bieliński

et al. 2015

Endokrynologia Polska

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 Visfatin concentrations in obese patients in relation to the presence of newly diagnosed glucose metabolism disordersStężenie wisfatyny u osób z otyłością w zależności od obecności świeżo wykrytych zaburzeń gospodarki węglowodanowej AbstractIntroduction: Visfatin, protein secreted by visceral adipose tissue, exerts insulin-mimetic actions. Visfatin concentration increases in patients with longer-standing diabetes type 2 with progressive b-cell dysfunction. Data about the role of visfatin in newly diagnosed glucose metabolism abnormalities are limited. Evaluation of visfatin concentration in patients with obesity, in relation to the presence of newly diagnosed glucose metabolism disorders. Material and methods:The study included 68 subjects with obesity, without a previous diagnosis of abnormal glucose metabolism. In all subjects we performed an oral glucose tolerance test, and according to the results the group was divided into the subgroups: A (n = 31), with glucose metabolism disorders (impaired fasting glucose, impaired glucose tolerance and type 2 diabetes); and B (n = 37), without abnormalities. In all subjects serum lipids, uric acid, C-peptide, glycated haemoglobin (HbA 1c ), creatinine, and serum visfatin concentrations were measured. The control group comprised 30 lean, healthy individuals with normal glucose tolerance. Results: We found elevated visfatin levels in obese individuals versus the control group (50.0 ± 48 vs. 26.7 ± 22.1 ng/mL; p = 0.01). Visfatin concentrations in both subgroups, A and B, did not differ (40.86 ± 27.84 vs. 57.7 ± 59.79 ng/mL; p = 0.19). In subgroup A visfatin concentration correlated significantly with triglycerides (r = 0.37, p = 0.038), HbA 1c (r = -0.43, p = 0.02), C-peptide (r = -0.38,p = 0.048), and waist-hip ratio (r = -0.41, p = 0.036). Conclusions: The presence of newly diagnosed glucose metabolism abnormalities in obese subjects had no influence on the visfatin level, probably due to preserved endogenous insulin secretion and relatively short exposure to hyperglycaemia in patients with prediabetes or at early stage of type 2 diabetes. (Endokrynol Pol 2015; 66 (2): 108-113)

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Section: Rycina 3 Korelacja Pomiędzy Wisfatyną a Hba 1c W Grupie A supporting

confidence: 80%

Section: Rycina 3 Korelacja Pomiędzy Wisfatyną a Hba 1c W Grupie A mentioning

confidence: 99%

Stężenie wisfatyny u osób z otyłością w zależności od obecności świeżo wykrytych zaburzeń gospodarki węglowodanowej

Kamińska

Kopczyńska

Bieliński

et al. 2015

Endokrynologia Polska

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“…We have no clear explanation as to why the SNP -1535 was associated with serum triglyceride and HDL-cholesterol levels. However, a similar association between the haplotype containing SNP -1535 and triglyceride levels has been reported in Chinese subjects [27]. Visfatin has an adipogenic effect that enhances the synthesis of triglycerides from glucose by primary cultured preadipocytes [3].…”

Section: Discussionmentioning

confidence: 93%

The -1535 Promoter Variant of The Visfatin Gene Is Associated with Serum Triglyceride and HDL-cholesterol Levels in Japanese Subjects

et al. 2008

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Abstract. Visfatin is a novel adipocytokine that is expressed by the visceral fat cells. We investigated the role of genetic variation in the visfatin gene in the pathophysiology of type 2 diabetes and clinical variables in Japanese subjects. The 11 exons, and the promoter region of the visfatin gene were screened for single nucleotide polymorphisms (SNPs) by PCRdirect sequencing. We found SNPs in the promoter region (SNP -1535T>C), exon 2 (SNP + 131C>G, Thr44Arg), and exon 7 (SNP + 903G>A). The allele and genotype frequencies of these SNPs showed no significant differences between 200-448 diabetic and 200-333 control subjects. However, the -1535T/T genotype was associated with lower serum triglyceride levels (T/T vs. T/C + C/C (p = 0.015) and T/T vs. C/C (p = 0.043)) and higher HDL-cholesterol levels (T/T vs. C/C, p = 0.0496) in the nondiabetic subjects. Reporter gene assay of 3T3-L1 adipocytes revealed that the promoter activity of -1535T and -1535C was similar, suggesting that the observed association may reflect linkage disequilibrium between -1535T>C and causative variations of the visfatin gene. ADIPOCYTES secrete a variety of proteins known as adipocytokines, which have various important roles in metabolism [1,2]. Visfatin is a novel adipocytokine strongly expressed by the visceral fat cells of both humans and mice [3]. Visfatin is identical to pre-B cell colony-enhancing factor (PBEF) which has been identified as a growth factor for early stage B cells [4]. Visfatin has an insulin-like effect on cultured cells. It stimulates glucose uptake by adipocytes, myocytes and osteoblasts [3,5], and inhibits glucose release from liver cells [3]. In addition, administration of visfatin to mice has been shown to decrease the plasma glucose level [3], and mice that are heterozygous (+/-) for visfatin have higher plasma glucose levels than wild-type mice [3]. Furthermore, clinical studies have shown that plasma visfatin levels are about two-fold higher in type 2 diabetic patients than in nondiabetic controls [6,7]. These findings suggest a role of visfatin in glucose metabolism and in the pathogenesis of type 2 diabetes. It has been reported that variations of the genes for other adipocytokines (e.g. adiponectin) can influence the risk of type 2 diabetes [8][9][10][11][12][13], but the relation between visfatin gene polymorphism and type 2 diabetes remains unknown. The visfatin/PBEF gene consists of 11 exons and 10 introns spanning 34.7-kb and is located on chromosome 7q22.2 [14]. In the present study, we systematically investigated polymorphisms of the coding region and promoter region of this gene in Japanese subjects and then performed association studies in type 2 diabetic and non-diabetic subjects. We also examined the

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“…In the last few years, genetic variants of the visfatin gene have been identified as molecular markers and showed significant associations with normal growth and development of animals and humans (Bailey et al, 2006;Jian et al, 2006;Blakemore et al, 2009). Among them, two indels (35 bp indel: AC_000161.1: g. 20540-20541 Ins ACTGGAATTC-TAGTTTAAAAATTGCTACTAATGAA in intron 4; 6 bp indel: AC_000161.1: g. 25873-25878 Del: TAAAAA in intron 5) of the bovine visfatin gene were significantly associated with growth traits in Chinese cattle (Wang et al, 2009, 2012).…”

Section: Introductionmentioning

confidence: 99%

Indels within the bovine visfatin gene affect its mRNA expression in longissimus muscle and subcutaneous fat

et al. 2016

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Abstract. Visfatin, an adipokine hormone produced primarily by visceral adipose tissue in mammals, has been identified as having a crucial role in growth and development of skeletal muscle and lipids. In this research, the effects of two indel loci (35 bp indel: AC_000161.1: g. 20540-20541 Ins ACTGGAATTCTAGTT-TAAAAATTGCTACTAATGAA located in intron 4; 6 bp indel: AC_000161.1: g. 25873-25878 Del: TAAAAA located in intron 5) of the visfatin gene on mRNA expression levels were studied by means of real-time quantitative PCR (qPCR) in longissimus muscle and subcutaneous fat from 95 Qinchuan cattle. Firstly, visfatin expression level in longissimus muscle of fetal cattle was prominently greater than that in calves and adult cattle (P < 0.05). The expression level of visfatin in subcutaneous fat was notably higher than that in longissimus muscle of calves and adult cattle (P < 0.05). Secondly, there were three genotypes (ins/ins, del/del and ins/del) and two genotypes (ins/del and ins/ins) detected in the 35 bp locus and 6 bp locus, respectively. Visfatin showed a minimum expression level in longissimus muscle in the homozygous deletion genotype at the 35 bp indel locus. Especially in calves, expression of visfatin was significantly greater in the heterozygous genotype than that in the homozygous insertion genotpye (P < 0.05). No statistical differences were found among visfatin expression level based on genotypes in the 6 bp indel locus (P > 0.05). Compared to heterozygous genotype, the expression level of homozygous insertion genotype was lower in longissimus muscle but greater in subcutaneous fat. These results imply that the expression levels of bovine visfatin vary with age and its indels might be putative variants mediating the expression of the bovine visfatin gene. This study provides useful information for further functional studies of bovine visfatin.

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The visfatin gene is associated with glucose and lipid metabolism in a Chinese population

Abstract: Serum visfatin levels may be related to visceral obesity in men, and the visfatin gene may account for variation of glucose and lipid parameters in Chinese subjects.

Cited by 81 publications

References 24 publications

Stężenie wisfatyny u osób z otyłością w zależności od obecności świeżo wykrytych zaburzeń gospodarki węglowodanowej

Stężenie wisfatyny u osób z otyłością w zależności od obecności świeżo wykrytych zaburzeń gospodarki węglowodanowej

The -1535 Promoter Variant of The Visfatin Gene Is Associated with Serum Triglyceride and HDL-cholesterol Levels in Japanese Subjects

Indels within the bovine visfatin gene affect its mRNA expression in longissimus muscle and subcutaneous fat

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