The viscoelasticity and structure of fibrous proteins

Mason, P.

doi:10.1007/bf01517275

Cited by 7 publications

(1 citation statement)

References 15 publications

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“…We also investigated the effects of fixation on viscoelastic properties of tissues. Formalin as a crosslinker of proteins is known to increase tissue stiffness and reduce damping properties with an approximated s of 6 min in tendons (33). Tendons are composed of a higher amount of collagen than liver tissue, which in turn contains more collagen than brain tissue.…”

Section: Discussionmentioning

confidence: 99%

A compact 0.5 T MR elastography device and its application for studying viscoelasticity changes in biological tissues during progressive formalin fixation

Braun

Tzschätzsch

Körting

et al. 2017

Magnetic Resonance in Med

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Purpose: To develop a method of compact tabletop magnetic resonance elastography (MRE) for rheological tests of tissue samples and to measure changes in viscoelastic powerlaw constants of liver and brain tissue during progressive fixation. Methods: A 10-mm bore, 0.5-T permanent-magnet-based MRI system was equipped with a gradient-amplifier-controlled piezo-actuator and motion-sensitive spin echo sequence for inducing and measuring harmonic shear vibrations in cylindrical samples. Shear modulus dispersion functions were acquired at 200-5700 Hz in animal tissues at different states of formalin fixation and fitted by the springpot powerlaw model to obtain shear modulus l and powerlaw exponent a. Results: In a frequency range of 300-1500 Hz, unfixed liver tissue was softer and less dispersive than brain tissue with l ¼ 1.68 6 0.17 kPa and a ¼ 0.51 6 0.06 versus l ¼ 2.60 6 0.68 kPa and a ¼ 0.68 6 0.03. Twenty-eight hours of formalin fixation yielded a 400-fold increase in liver l, 25-fold increase in brain l, and two-fold reduction in a of both tissues.

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Section: Discussionmentioning

confidence: 99%

A compact 0.5 T MR elastography device and its application for studying viscoelasticity changes in biological tissues during progressive formalin fixation

Braun

Tzschätzsch

Körting

et al. 2017

Magnetic Resonance in Med

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show abstract

Viscoelasticity and structure of fibrous proteins

Mason

Unsworth

1971

Kolloid-Z.u.Z.Polymere

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Dynamic mechanical properties of α-keratin fibers during extension

Danilatos

Feughelman

1979

Journal of Macromolecular Science, Part B

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Lincoln wool fibers have been tested for their dynamic modulus E' and loss angle 6 at various values of strain in the "Hookean", yield, and postyield regions by applying various rates of extension, and in atmospheres varying from 0 to 100% relative humidity. An estimate of the energy loss per cycle for the whole fiber exhibits only minor change over the complete range of change of the humidity and strain. The dynamic modulus E' and loss angle 6 change considerably with overall strain of the fiber, especially under more moist conditions. The variation of E' and 6 can be interpreted in terms of the microfibrilmatrix composite which forms the major component of a-keratin fibers. In particular, the mechanical effect of the unfolding of the a-helical structure contained within the microfibrils is shown to he independent of relative humidity. The results indicate that the a-helical component is responsible for a fiied amount of the Young's modulus of the initial stiff region (the Hookean region) of the stress-strain curve of Lincoln wool fibers. This fixed amount of 1.2 X lo9 Newtons mz is confirmed from other independent mechanical estimates.

show abstract

The viscoelasticity and structure of fibrous proteins

Cited by 7 publications

References 15 publications

A compact 0.5 T MR elastography device and its application for studying viscoelasticity changes in biological tissues during progressive formalin fixation

A compact 0.5 T MR elastography device and its application for studying viscoelasticity changes in biological tissues during progressive formalin fixation

Viscoelasticity and structure of fibrous proteins

Dynamic mechanical properties of α-keratin fibers during extension

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