The visceral adiposity index and lipid accumulation product as predictors of cardiovascular events in normal weight subjects

Darroudi, Susan; Soflaee, Sara Saffar; Hosseini, Zeinab; Farmad, Maryam Safari; Mirshafiei, Hassan; Andalibi, Mohammad Sobhan Sheikh; Eslamiyeh, Mostafa; Donyadideh, Ghazaleh; Aryan, Reihaneh; Toosi, Mansoureh Sadat Ekhteraee; Talkhi, Nasrin; Esmaily, Habibollah; Samadi, Sara; Mohammadpour, Amir Hooshang; Rad, Mostafa; Ferns, Gordon A.; Ghayour‐Mobarhan, Majid; Moohebati, Mohsen

doi:10.1016/j.clnesp.2022.10.015

Cited by 12 publications

(4 citation statements)

References 28 publications

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“…Thus, even if VAI and TG/HDL-C index were lower in females than in males, they might capture an early stage of metabolic disturbance that is not pictured by the glycaemic state but is still clinically important and they could be better predictors of MI. This is in line with a recent study highlighting that VAI is associated with CV events in normal weight and over-weight subjects, but not in those who had obesity [39], suggesting that indexes derived from multiple parameters, both anthropometric Additionally, a Chinese study shows that VAI is significantly associated with intracranial atherosclerotic stenosis in middle-aged and elderly females [40]. Accordingly, in a recent clamp-based study in subjectswithout diabetes, there was greater deterioration of insulin sensitivity and greater fat accumulation in females than in males [11].…”

Section: Discussionsupporting

confidence: 93%

Sex differences in the association between insulin resistance and non-fatal myocardial infarction across glycaemic states

Riccio,

Fortin,

Mellbin

et al. 2024

Cardiovasc Diabetol

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Background Females are generally less prone to cardiovascular (CV) events than males, but this protection is trumped by diabetes. The mechanism behind the increased relative risk in females with diabetes is not fully understood. Insulin resistance (IR) is suggested to be a more important contributor to CV morbidity in females than in males. We aim to investigate differences in the association between IR indexes (Homeostatic Model Assessment of IR - HOMA-IR, visceral adiposity index – VAI, and triglycerides/high-density lipoprotein-cholesterol - TG/HDL-C index), and a first non-fatal myocardial infarction (MI) across different glycaemic states. Methods IR indexes were calculated in a population with (n = 696) and without (n = 707) a first non-fatal MI, free from known diabetes. MI cases were investigated at least six weeks after the event. All participants were categorized by an oral glucose tolerance test as having normal glucose tolerance, impaired fasting glucose, impaired glucose tolerance, or newly diagnosed diabetes. Comparison of proportion of glycaemic states by sex was tested by chi-square test. The associations between sex, a first non-fatal MI, IR indexes, and traditional CV risk factors were analysed by multivariate logistic regression models. Continuous variables were logarithmically transformed. Results Of the total population 19% were females and 81% males, out of whom 47% and 50% had a first non-fatal MI, respectively. Compared with males, females were older, less often smokers, with lower body mass index and higher total cholesterol and high-density lipoprotein cholesterol levels. The proportion of glycaemic states did not differ between the sexes (p = 0.06). Females were less insulin resistant than males, especially among cases and with normal glucose tolerance. In logistic regression models adjusted for major CV risk factors including sex, the associations between VAI and TG/HDL-C index and a first non-fatal MI remained significant only in females (odds ratios and 95% confidence intervals: 1.7, 1.0-2.9, and 1.9, 1.1–3.4 respectively). Conclusions These results support the assumption that IR indexes based on anthropometrics and lipid panel, i.e., VAI and TG/HDL-C, could be a better measure of IR and CV-predictor for non-fatal MI in females, even without glycaemic perturbations.

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Section: Discussionsupporting

confidence: 93%

Sex differences in the association between insulin resistance and non-fatal myocardial infarction across glycaemic states

Riccio,

Fortin,

Mellbin

et al. 2024

Cardiovasc Diabetol

View full text Add to dashboard Cite

show abstract

“…Thus, even if VAI and TG/HDL-C index were lower in females than in male, they might capture an early stage of metabolic disturbance that is not pictured by the glycaemic state but is still clinically important and they could be better predictors of MI. This is in line with a recent study highlighting that VAI is associated with CV events in normal weight and over-weight subjects, but not in those who had obesity (39), suggesting that indexes derived from multiple parameters, both anthropometric and laboratory, are more able to identify CV risk in healthier populations.…”

Section: Discussionsupporting

confidence: 91%

Sex differences in the association between insulin resistance and myocardial infarction across glycaemic states

Riccio,

Fortin,

Mellbin

et al. 2023

Preprint

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Background: Females are generally less prone to cardiovascular (CV) events than males, but this protection in trumped by the presence of diabetes. The mechanism behind the increased relative risk in females with diabetes is not fully understood. Insulin resistance (IR) is suggested to be a more important contributor to CV morbidity in females than in males. We aim at investigating differences in the association between IR indexes (Homeostatic Model Assessment of IR - HOMA-IR, visceral adiposity index – VAI, and triglycerides/high-density lipoprotein-cholesterol - TG/HDL-C index), and a first myocardial infarction (MI) across different glycaemic states. Methods: In this post-hoc analysis of the PAROKRANK study, IR indexes were calculated in a population with (n=696) and without (n=707) a first MI, free from known diabetes. MI patients were investigated at least six weeks after the event. All participants were categorized by an oral glucose tolerance test as having normal glucose tolerance, impaired fasting glucose, impaired glucose tolerance, or newly diagnosed diabetes. Comparison of proportion of glycaemic states by sex was tested by chi-square test. The associations between sex, a first MI, IR indexes, and traditional CV risk factors were analysed by multivariate logistic regression models. Continuous variables were logarithmically transformed. Results: Of the total population 19% were females and 81% males, out of whom 47% and 50% had a first MI, respectively. Compared with males, females were older, less often smokers, with lower body mass index and higher total cholesterol and high-density lipoprotein cholesterol levels. The proportion of glycaemic states did not differ between the sexes (p=0.06). Females were less insulin resistant than males. In logistic regression models adjusted for major CV risk factors including sex, the associations between VAI and TG/HDL-C index and a first non-fatal MI remained significant only in females (odds ratios and 95% confidence intervals: 1.7, 1.0-2.9 and 1.9, 1.1-3.4 respectively). Conclusions: These results support the assumption that IR is of special importance as a CV risk factor in females and IR indexes based on anthropometrics and lipid panel, i.e., VAI and TG/HDL-C, could be a better measure of IR and CV-predictor in females than in males.

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“…Their results supported what was found in our study in pertains to the direct correlations between obesity parameters, the LOS, the risk factors (age, gender, marital status, income, educational level) and health variables (lipide profile, hemoglobin sugar, HS-CRP, blood pressure, daily activity, smoking). Another study [ 36 ] that investigated the relationships between BMI and the visceral adiposity index and lipid accumulation product. In their study, only 1 obesity parameter (BMI) was used and not all risk factors of CAD have been addressed, such as DM, hypertension, smoking, being a male, and living a sedentary life style.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

The association of traditional obesity parameters with the length of stay among patients with coronary artery disease: A cross-sectional study

Hayajneh,

Alhusban,

Rababa

et al. 2023

Medicine

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There is a strong association between obesity and coronary artery disease (CAD). Obesity is measured using traditional obesity parameters, such as body mass index, body adiposity index, waist circumference (WC), and hip circumference. The aim of this study is to explore the association between traditional obesity parameters and the length of stay (LOS) among hospitalized CAD patients. An original correlative descriptive study was carried out using secondary data analysis, in which 220 hospitalized Jordanian CAD patients were recruited from Jordan northern and middle regions. Age, WC, triglycerides, and high- sensitivity C-reactive protein were all positive predictors of the total hospital LOS among hospitalized patients with CAD. The WC, age, triglycerides, and high-sensitivity C-reactive protein levels were significantly positively associated with total LOS. Healthcare providers, including nurses, should take into account these significant positive predictors of LOS to achieve better health outcomes and improve patient satisfaction.

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The visceral adiposity index and lipid accumulation product as predictors of cardiovascular events in normal weight subjects

Cited by 12 publications

References 28 publications

Sex differences in the association between insulin resistance and non-fatal myocardial infarction across glycaemic states

Sex differences in the association between insulin resistance and non-fatal myocardial infarction across glycaemic states

Sex differences in the association between insulin resistance and myocardial infarction across glycaemic states

The association of traditional obesity parameters with the length of stay among patients with coronary artery disease: A cross-sectional study

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