The virgin population of Neisseria gonorrhoeae in Stockholm has decreased and antimicrobial resistance is increasing.

Abstract

Aims-To investigate the evolution of chromosomal and plasmid mediated resistance for ampicillin and tetracycline of N gonorrhoeae strains in Stockholm during 1982-1993. Methods-A total of 404 gonococcal strains isolated in 1982, 1987, 1990, 1992, 1993 Results-Increased proportions of chromosomally mediated resistance to tetracycline (p < 0.001) as well as plasmid mediated resistance to both ampicillin (p < 0.02) and tetracycline were found in the later part of the study. In 1991 the first gonococcus with tet(M) plasmid was isolated in Sweden. The proportion of strains with chromosomally mediated resistance for ampicillin did not change during the study period. The proportion of gonococcal strains with the 39 kb conjugative plasmid was increased in the later part of the study. Conclusions-The increased proportion of N gonorrhoeae strains with resistance to ampicillin and tetracycline is most likely due to importation of strains from areas with high prevalence of antibiotic resistant gonococci. The proportion of N gonorrhoeae strains with tet(M) plasmids is low in Sweden, but might increase in the same way as the proportion of PPNG strains has increased during 1982-1993. (Genitourin Med 1995;71:234-238)

The phase-variable pilus-associated protein PilC is commonly expressed in clinical isolates of Neisseria gonorrhoeae, and shows sequence variability among strains

“…The remaining clinical isolates described in this study were isolated from patient samples at the Department of Microbiology Stockholm Söder Hospital, Stockholm, Sweden, with the exception of GC-692 obtained from Dr S. Ringertz, Karolinska Hospital, Stockholm, Sweden. The strains were verified as previously described (Bäckman et al ., 1995). The strains were classified into serovars with mAbs directed against PI (Ph-panel, Boule Diagnostics) (Knapp et al ., 1984; Sandström et al ., 1985) and the antigens were prepared as previously described (Bäckman et al ., 1985).…”

Sexually Transmitted Infections in Canada: A Sticky Situation

“…However, multidrug-resistant NG isolates are becoming increasingly common (53). Resistance of NG to tetracyclines, aminopenicillins and erythromycin was common by the 1990s (54). Fluoroquinolone antibiotics represented a promising single-dose therapy for uncomplicated NG, but resistance to these drugs emerged rapidly in the early 2000s; recent reports suggest that up to 30% of NG isolates in Ontario are fluoroquinolone resistant (53,55).…”