2013
DOI: 10.1128/jvi.02474-13
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The Viral Ubiquitin Ligase ICP0 Is neither Sufficient nor Necessary for Degradation of the Cellular DNA Sensor IFI16 during Herpes Simplex Virus 1 Infection

Abstract: The cellular protein IFI16 colocalizes with the herpes simplex virus 1 (HSV-1) ubiquitin ligase ICP0 at early times of infection and is degraded as infection progresses. Here, we report that the factors governing the degradation of IFI16 and its colocalization with ICP0 are distinct from those of promyelocytic leukemia protein (PML), a well-characterized ICP0 substrate. Unlike PML, IFI16 colocalization with ICP0 was dependent on the ICP0 RING finger and did not occur when proteasome activity was inhibited. Exp… Show more

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Cited by 91 publications
(183 citation statements)
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References 42 publications
(90 reference statements)
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“…Thus, consistent with earlier reports (20)(21)(22), IFI16 is degraded in wild-type virus-infected HEp-2 and HEL cells. In these cells STING is stable.…”
Section: Discussionsupporting
confidence: 81%
“…Thus, consistent with earlier reports (20)(21)(22), IFI16 is degraded in wild-type virus-infected HEp-2 and HEL cells. In these cells STING is stable.…”
Section: Discussionsupporting
confidence: 81%
“…In addition, this study demonstrated that IFI16 is phosphorylated following HSV-1 infection, likely targeting it for proteasomal degradation [45]. However, another study which raised concerns about the difficulties in distinguishing between the direct and indirect effects of ICP0, reasoned that ICP0 does have an impact on IFI16 related activities but that IFI16 is not necessarily an ICP0 substrate [56]. Nevertheless, this study agrees that following HSV-1 infection IFI16 is degraded by the proteasome, which is a very effective mechanism to limit prolonged viral detection.…”
Section: Host and Pathogen Regulation Of Aim2 And Ifi16mentioning
confidence: 75%
“…IFI16 has been reported to bind to herpesviral DNA in HFF cells (9,17). Furthermore, IFI16 localizes to intranuclear sites near the periphery of the nucleus near genome complexes (24) and within viral replication compartments during productive infection (27). Finally, HSV-1 ICP0 promotes the degradation of IFI16 in HFFs and prevents IRF-3 signaling (8).…”
Section: Discussionmentioning
confidence: 99%