“…et al, 1999). Reovirus and MYXV replicate to higher levels in cancer cells with reduced expression of p53, and although this is not the major determinant dictating their selective replication in tumor cells, it enhances efficiency of infection (Kim et al, 2010 (Platanias, 2005;Everts & van der Poel, 2005). A well characterized ISG involved in blocking viral replication is PKR, as discussed previously (Sadler & Williams, 2008;Everts & van der Poel, 2005).…”