The Vinylogous Mukaiyama Aldol Reaction in Natural Product Synthesis

Doubly Vinylogous Aldol Reaction of Furoate Esters with Aldehydes and Ketones

“…The vinylogous aldol reaction is an extension of the aldol reaction, , wherein one or more alkenes intercede in the enolate precursor between the site of enolization and the carbonyl. , The parent transformation produces a functionally dense δ-hydroxy-α,β-unsaturated carbonyl compound and provides a useful synthetic disconnection for complex molecule synthesis. This transformation has been the subject of much research, and enantioselective methods using silicone dienolates with either Lewis acid, metal, or nucleophilic catalysis have been reported, as have more direct metalo-enolate-derived methods as well as enantioselective methods .…”