The View of the Clinician on Features of the Clinical Course and Issues of Vaccinal Prevention of Viral Hepatitis A

Abstract

The article is devoted to peculiarities of the clinical course of hepatitis A. There is presented the modern view of the immunopathogenesis of hepatitis A virus (HAV) infection. The attention is focused on possibilities of the development of severe, fulminant course especially in patients of the old age category. The authors give the analysis of the main causes of severe fulminant forms of the disease. There are pointed out clinical and laboratory criteria for the assessment of the severity of the course of HAV infection. This article includes information on current aspects of vaccination against HAV, with the indication of the population, especially needed of vaccination