The viability of articular cartilage in fresh osteochondral allografts after clinical transplantation.

Czitrom, Andrei A.; Keating, Shane; Gross, Allan E.

doi:10.2106/00004623-199072040-00016

Cited by 259 publications

(122 citation statements)

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“…Indeed, allograft transplantation is a complicated process with a dynamic interplay of multiple tissue interactions. The predominant paradigm, allograft function is maximized by fresh grafts that optimize chondrocyte viability and maintain the extracellular matrix, is probably true but is an oversimplification of a complex process [21,47,49].…”

Section: Discussionmentioning

confidence: 99%

Material Properties of Fresh Cold-stored Allografts for Osteochondral Defects at 1 Year

Ranawat

Vidal

Chen

et al. 2008

Clin Orthop Relat Res

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Little is known about the long-term properties of fresh cold-stored osteochondral allograft tissue. We hypothesized fresh cold-stored tissue would yield superior material properties in an in vivo ovine model compared to those using freeze-thawed acellular grafts. In addition, we speculated that a long storage time would yield less successful grafts. We created 10-mm defects in medial femoral condyles of 20 sheep. Defects were reconstructed with allograft plugs stored at 4°C for 1, 14, and 42 days; control specimens were freeze-thawed or defect-only. At 52 weeks, animals were euthanized and retrieved grafts were analyzed for cell viability, gross morphology, histologic grade, and biomechanical and biochemical analysis. Explanted coldstored tissue had superior histologic scores over freezethawed and defect-only grafts. Specimens stored for 1 and 42 days had higher equilibrium moduli and proteoglycan content than freeze-thawed specimens. We observed no difference among any of the cold-stored specimens for chondrocyte viability, histology, equilibrium aggregate modulus, proteoglycan content, or hypotonic swelling. Reconstructing cartilage defects with cold-stored allograft resulted in superior histologic and biomechanical properties compared with acellular freeze-thawed specimens; however, storage time did not appear to be a critical factor in the success of the transplanted allograft.

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Section: Discussionmentioning

confidence: 99%

Material Properties of Fresh Cold-stored Allografts for Osteochondral Defects at 1 Year

Ranawat

Vidal

Chen

et al. 2008

Clin Orthop Relat Res

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“…Since the first attempts at osteochondral transplantation by Lexer in 1908, 1,2 both animal and clinical studies in immunology and transplantation have shown that transplanted fresh cadaver cartilage is viable. [3][4][5][6][7][8][9] In these small fragments, allograft is replaced by host bone in a homogeneous fashion by creeping substitution. [10][11][12] Since 1972, we have used fresh osteochondral allografts for the reconstruction of joint defects due to injury.…”

mentioning

confidence: 99%

Fresh Osteochondral Allografts for Post-Traumatic Osteochondral Defects of the Knee

Ghazavi¹,

Pritzker

Davis³

et al. 1997

The Journal of Bone and Joint Surgery. British volume

198

125

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We used fresh small-fragment osteochondral allografts to reconstruct post-traumatic osteochondral defects in 126 knees of 123 patients with a mean age of 35 years. At a mean follow-up of 7.5 years (2 to 20), 108 knees were rated as successful (85%) and 18 had failed (15%).The factors related to failure included age over 50 years (p = 0.008), bipolar defects (p < 0.05), malaligned knees with overstressing of the grafts, and workers' compensation cases (p < 0.04). Collapse of the graft by more than 3 mm and of the joint space of more than 50% were seen more frequently in radiographs of failed grafts.Our encouraging clinical results for fresh smallfragment osteochondral allografts show that they are indicated for unipolar post-traumatic osteochondral defects of the knee in young active patients.

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“…By comparing cryopreservation techniques with fresh osteochondral allograft, it was found that cryopreservation resulted in less immunologic antigenicity but also marked degeneration of the cartilages matrix and chondrocyte viability. In 1985 study by Czitrom et al, found that chondrocyte viability and fresh osteochondral allograft ranged from 69% to 99% when assessed in culture media from biopsy specimens by S04 and 3H-cytidine auto radiography and grafts 1-6 years after implantation [54]. One six-year graft had only 37% chondrocyte viability but they were actively producing proteogylcans.…”

Section: Allograftmentioning

confidence: 99%

Cartilage damage: a review of surgical repair options and outcomes

Pettit¹,

Kolvek²,

Langworthy³

2017

Phys Med Rehabil Res

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The viability of articular cartilage in fresh osteochondral allografts after clinical transplantation.

Cited by 259 publications

References 0 publications

Material Properties of Fresh Cold-stored Allografts for Osteochondral Defects at 1 Year

Material Properties of Fresh Cold-stored Allografts for Osteochondral Defects at 1 Year

Fresh Osteochondral Allografts for Post-Traumatic Osteochondral Defects of the Knee

Cartilage damage: a review of surgical repair options and outcomes

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