The vestibular evoked myogenic potentials (<scp>VEMP</scp>) score: a promising tool for evaluation of brainstem involvement in multiple sclerosis

Gabelić, Tereza; Skorić, Magdalena Krbot; Adamec, Ivan; Barun, Barbara; Zadro, Ivana; Habek, Mario

doi:10.1111/ene.12557

Cited by 43 publications

(32 citation statements)

References 26 publications

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“…The use of such score has been proposed very recently as a promising tool for evaluation of brainstem involvement in multiple sclerosis (Gabelić et al, 2014). In our cases, the VEMP scores correlated consistently well with clinical scores, indicating their usefulness in the representation of a certain clinical picture from a neurophysiological point of view, also in PD patients.…”

Section: Neurophysiological-clinical Correlationssupporting

confidence: 71%

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Paired neurophysiological and clinical study of the brainstem at different stages of Parkinson’s Disease

Natale¹,

Ginatempo²,

Paulus³

et al. 2015

Clinical Neurophysiology

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Section: Neurophysiological-clinical Correlationssupporting

confidence: 71%

“…To estimate severity of impairment detected in each VEMP recording of every subject, a novel score, called VEMP score, was built according to Gabelić et al (2014). The value of the VEMP score increased consistently with the detection of no alteration (= 0), delay (= 1), amplitude reduction (= 2), or absence (= 3) of the response.…”

Section: Vemp Analysismentioning

confidence: 99%

Paired neurophysiological and clinical study of the brainstem at different stages of Parkinson’s Disease

Natale¹,

Ginatempo²,

Paulus³

et al. 2015

Clinical Neurophysiology

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“…However, these studies assessed brainstem dysfunction using only brainstem auditory evoked potentials (BAEP), a method that evaluates just one of the numerous pathways in that area of the central nervous system. Additional mode of brainstem assessment is the vestibular evoked myogenic potentials (VEMP), which have shown to be of value in the evaluation of brainstem involvement in MS (15). …”

Section: Discussionmentioning

confidence: 99%

Tongue somatosensory evoked potentials reflect midbrain involvement in patients with clinically isolated syndrome

Skorić¹,

Adamec²,

Crnošija³

et al. 2016

Croat Med J

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AimTo test the hypothesis that tSSEP findings reflect clinical and MRI MS lesions, the aim of this study was to investigate tSSEP changes in patients with clinically isolated syndrome (CIS) in relation to clinical and brainstem MRI findings. The second aim was to investigate whether the interpretation of the tSSEP results in the form of the tSSEP score enables better evaluation of the afferent trigeminal pathway involvement than analyzing each tSSEP parameter separately.Methods115 consecutive CIS patients were enrolled from August 1, 2014 until March 1, 2016. Facial sensory symptoms and brainstem MRI (1.5 T) lesions were analyzed. tSSEP testing was performed for each patient from the raw tSSEP data. The tSSEP score was calculated separately for the left and right side (according to the cut-off values for absent response and prolonged latency of the main component, P1 (0 = normal response, 1 = prolonged latency, 3 = absent response) and the two values were summed.ResultsThere was no difference in the absolute values of the tSSEP variables regarding the presence of clinical symptoms. No association was found between tSSEP abnormalities and clinical symptoms (P = 0.544). Brainstem lesions (midbrain and pons) were associated with the absent tSSEP responses (P = 0.002 and P = 0.005, respectively). tSSEP score was significantly higher in patients with brainstem lesions (P = 0.01), especially midbrain (P = 0.004) and pontine (P = 0.008) lesions. Binary logistic regression showed that tSSEP score had a significant effect on the likelihood that patients have midbrain MR lesions, χ2(1) = 6.804, P = 0.009; and the model correctly classified 87% of cases.ConclusionsThe consistent finding of this study was the association between tSSEP and midbrain lesions on MRI, indicating that tSSEP evaluates proprioception of the face. This study establishes the value of tSSEP in assessing brainstem function in early multiple sclerosis.

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“…Therefore oVEMPs may be helpful to assess brainstem involvement in patients with MS [90][91][92][93], in particular of the MLF, which often becomes symptomatic as INO in these patients [87,88]. Gabelic et al measured AC oVEMPs and cVEMPs in MS patients and found that patients with symptoms of brainstem involvement were more likely to show VEMP abnormalities than those without brainstem symptoms [91]. Therefore oVEMPs are likely to complement other evoked potentials in MS, like auditory brainstem responses, and may also detect silent lesions, though their comparative sensitivity is not yet known.…”

Section: Central Vestibular Disordersmentioning

confidence: 99%

Clinical Utility of Ocular Vestibular-Evoked Myogenic Potentials (oVEMPs)

Weber

Rosengren

2015

Curr Neurol Neurosci Rep

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The vestibular evoked myogenic potentials (VEMP) score: a promising tool for evaluation of brainstem involvement in multiple sclerosis

Abstract: Interpretation of the oVEMP and cVEMP results in the form of the VEMP score enables better evaluation of brainstem involvement than either of these evoked potentials alone and correlates well with disability.

Cited by 43 publications

References 26 publications

Paired neurophysiological and clinical study of the brainstem at different stages of Parkinson’s Disease

Paired neurophysiological and clinical study of the brainstem at different stages of Parkinson’s Disease

Tongue somatosensory evoked potentials reflect midbrain involvement in patients with clinically isolated syndrome

Clinical Utility of Ocular Vestibular-Evoked Myogenic Potentials (oVEMPs)

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