The vertebral body: radiographic configurations in various congenital and acquired disorders.

Kumar, Rajendra; Guinto, Faustino C.; Madewell, John E.; Swischuk, Leonard E.; David, Ronald B.

doi:10.1148/radiographics.8.3.3380991

Cited by 59 publications

(32 citation statements)

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“…There are, however, common variants of vertebrae development not due to compression fractures which need to be taken into consideration in any screening programme of the spine, summarized in a recent review by the STOPP investigators [39]. Table 1 summarizes the examples of normal variants and artefacts that may be seen on lateral thoracolumbar X-ray in childhood [39,40,41,42]. …”

Section: Assessment Of Bone Healthmentioning

confidence: 99%

Skeletal Fragility in Children with Chronic Disease

2016

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Skeletal fragility associated with underlying childhood chronic disease is a systemic disorder of poor bone growth and reduction in bone turnover which can lead to abnormal bone mass, geometry and microarchitecture. Due to the growth potential unique to children, remarkable bone recovery following a transient threat to the bone can occur if there is concurrent growth. Addressing bone health in these children should focus on improvement in growth, puberty and removing the primary insult. In conditions where there is a little scope for bone recovery and limited residual growth, bone-targeted therapy may need to be considered, even though there is currently limited evidence. The importance of early detection of signs of bone fragility, by active screening for vertebral fracture using newer imaging techniques such as dual-energy X-ray absorptiometry lateral vertebral morphometry, may now be possible. There is currently, a paucity of evidence to support prophylactic use of anti-resorptive therapy. Where poor growth and low bone turnover are seen, the use of growth-promoting therapies and anabolic bone-protective agents may be more physiological and should be evaluated in well-designed trials. Collaborative studies on long-term fracture outcome and well-designed trials of bone-protective therapies are needed and to be encouraged.

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Section: Assessment Of Bone Healthmentioning

confidence: 99%

Skeletal Fragility in Children with Chronic Disease

2016

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“…Ependymoma, dermoid cysts, epidermoid cysts, schwannoma, lipomas, and lymphomas frequently show thinning of laminae and pedicles [4, 7, 8, 20]. Dural ectasia, associated with inherited disorders such as Marfan syndrome, and Ehlers–Danlos syndrome, and neurofibromatosis is also a cause of scalloping of vertebral bodies [4, 8, 9, 11, 12, 15]. There have been few reports, however, of scalloping of the spinal osseous structures caused by HNP.…”

Section: Discussionmentioning

confidence: 99%

“…As for other causes of scalloping, communicating hydrocephalus, Marfan syndrome, Ehlers–Danlos syndrome, ankylosing spondylitis, neurofibromatosis, achondroplasia, Morquio syndrome, Hurler syndrome, acromegaly, tuberculosis, and fungal infections have been reported [4, 8–15]. Erosion of the spinal osseous structure by herniated nucleus pulposus (HNP) has rarely been reported.…”

Section: Introductionmentioning

confidence: 99%

Osseous erosion by herniated nucleus pulposus mimicking intraspinal tumor: a case report

Yoshioka

Sairyo

Sakai

et al. 2010

J Orthopaed Traumatol

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Erosion of spinal osseous structure, so-called scalloping, has been rarely reported associated with herniated nucleus pulposus (HNP). We report a rare case of HNP causing erosion of the spinal osseous structure (including lamina). The patient was an 81-year-old woman with 3-year history of low-back pain and left leg radiating pain. Muscle weakness of the left leg was also apparent. Computed tomography following myelography showed severe compression of the dural sac at the level of L3–L4; furthermore, erosion of the lamina, pedicle, and vertebral body was noted, indicating that the space-occupying mass was most probably a tumorous lesion. The mass also showed calcification inside. During the surgery, the mass was confirmed to be an HNP with calcification. Following resection, the pain disappeared. Surgeons should be aware of the possibility of scalloping of the vertebrae caused by HNP mimicking a tumorous lesion.

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“…monly seen in premature male infants. They usually fuse by 6 months of age [28,29] . As a final example, the inferior pubic rami are not ossified at birth and do not fully ossify until about 7 or 8 years of age.…”

Section: Exclude Normal Age-related Appearancesmentioning

confidence: 99%

Skeletal Dysplasias: An Overview

Offiah

2015

Endocrine Development

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Constitutional disorders of bone, commonly termed skeletal dysplasias (SDs), are inherited disorders of cartilage and/or bone that affect their growth, morphometry and integrity. Associated skeletal abnormalities are usually but not invariably symmetrical. They may be classified as osteochondrodysplasias, which are conditions associated with abnormalities of the growth (dysplasias) or texture (osteodystrophy) of bone and/or cartilage, or dysostoses, which are conditions secondary to abnormal blastogenesis (occurring at or around the 6th week of in utero life). Skeletal involvement may also occur in other multisystem hereditary and acquired syndromes. The 2010 Nosology and Classification of Genetic Skeletal Disorders listed 456 conditions, of which approximately 50 are perinatally lethal, and 316 are associated with one or more of 226 genes. When an SD is suspected, a standard series of radiographs, collectively known as a skeletal survey, should be performed. The diagnosis of individual conditions is highly dependent on radiographic pattern recognition, which is achieved through a systematic review of the images and enhanced by discussion with colleagues and through the use of available tools, such as atlases and digital databases. This article summarises a systematic approach to the diagnosis of SDs, demonstrated using examples of some of the more common lethal and non-lethal conditions.

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The vertebral body: radiographic configurations in various congenital and acquired disorders.

Abstract: tlons are diseasespecific and when recognized on radiographs, make correct diagnosis possible. I I Figure 1 Schematic drawing depicting the development of normal and abnormal vertebral bodies. The vertebral body: Acquired and congenital disorders Kumar et al.

Cited by 59 publications

References 0 publications

Skeletal Fragility in Children with Chronic Disease

Skeletal Fragility in Children with Chronic Disease

Osseous erosion by herniated nucleus pulposus mimicking intraspinal tumor: a case report

Skeletal Dysplasias: An Overview

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