The Versatility of Mannich Reaction: An Overview

Abstract

- One of the most significant processes for creating carbon-carbon bonds in organic synthesis is the Mannich reaction. It offers amino carbonyl compounds, crucial synthetic building blocks for many medicines. This Mannich bases are made by combining primary and/or secondary amines, formaldehyde, and active hydrogen molecules. Among those that are active hydrogen compounds include an acid, phenol, ketone, amide, etc. contribution involved the synthesis of 3,5 dimethyl carboxamide using a number of biologically active sulphonamides, which was followed by analysis of elements and spectrum analyses techniques using, IR, UV and 1HNMR. Escherichia coli, Staphylococcus aureus, and Bacillus subtilis were among the pathogenic microorganisms tested for the compounds’ antibacterial efficacy at different doses. We examined the bactericidal effectiveness of parent sulphonamides and derived Mannish bases. To establish whether synthetic Mannish bases were dangerous, the LD50 test was utilised.