The versatility and adaptation of bacteria from the genus Stenotrophomonas

Ryan, Robert P.; Monchy, Sébastien; Cardinale, Massimiliano; Taghavi, Safiyh; Crossman, Lisa; Avison, Matthew B.; Berg, Gabriele; Lelie, Daniël van der; Dow, J. Maxwell

doi:10.1038/nrmicro2163

Cited by 650 publications

(497 citation statements)

References 151 publications

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“…This strain has great potential for applications in biotechnology and biological control due to its ability to both promote plant growth and protect roots against biotic and abiotic stresses [37], yet little was known about its mode of action. Antibiotics, lytic enzymes, and osmoprotective substances were previously identified [38,39], but now new mechanisms associated with osmotic stress using a transcriptomic approach have been identified. As such, the production and excretion of glucosylglycerol (GG) were found as mechanisms for the stress protection of this Stenotrophomonas strain [40].…”

Section: The Potential Of Next-generation Bio-productsmentioning

confidence: 99%

Next-Generation Bio-Products Sowing the Seeds of Success for Sustainable Agriculture

et al. 2013

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Abstract:Plants have recently been recognized as meta-organisms due to a close symbiotic relationship with their microbiome. Comparable to humans and other eukaryotic hosts, plants also harbor a "second genome" that fulfills important host functions. These advances were driven by both "omics"-technologies guided by next-generation sequencing and microscopic insights. Additionally, these new results influence applied fields such as biocontrol and stress protection in agriculture, and new tools may impact (i) the detection of new bio-resources for biocontrol and plant growth promotion, (ii) the optimization of fermentation and formulation processes for biologicals, (iii) stabilization of the biocontrol effect under field conditions, and (iv) risk assessment studies for biotechnological applications. Examples are presented and discussed for the fields mentioned above, and next-generation bio-products were found as a sustainable alternative for agriculture.

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Section: The Potential Of Next-generation Bio-productsmentioning

confidence: 99%

Next-Generation Bio-Products Sowing the Seeds of Success for Sustainable Agriculture

et al. 2013

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“…Limited phenotypic analysis of S. maltophilia strains in vitro and the recent sequencing of the S. maltophilia genome both suggest that the organism has traits that have been linked to the virulence of other bacteria (Crossman et al, 2008;Denton & Kerr, 1998;Looney et al, 2009;Nicoletti et al, 2011;Rocco et al, 2009;Ryan et al, 2009). Also, inoculation of S. maltophilia into the lungs of mice results in a marked inflammatory response within 24 h that involves, among other things, elevated cytokines (Di Bonaventura et al, 2010;Waters et al, 2007;Zgair & Chhibber, 2010a).…”

Section: Introductionmentioning

confidence: 99%

“…Originally classified as Pseudomonas maltophilia and then Xanthomonas maltophilia, S. maltophilia belongs to the c-Proteobacteria and is the best known of the 11 species that form the genus Stenotrophomonas Lee et al, 2011;Ryan et al, 2009;Yi et al, 2010). In nature, S. maltophilia exists in a wide variety of environments, being found in water, soil and plant material (Denton & Kerr, 1998;Ryan et al, 2009). But, S. maltophilia also occurs in man-made water systems, and most problematic is its presence in devices and reagents in hospital settings (Denton & Kerr, 1998;Looney et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Stenotrophomonas maltophilia strains replicate and persist in the murine lung, but to significantly different degrees

et al. 2011

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The environmental bacterium Stenotrophomonas maltophilia is increasingly described as a multidrug-resistant pathogen of humans, being associated with pneumonia, among other diseases. But the degree to which S. maltophilia is capable of replicating in a mammalian host has been an issue of controversy. Using a model of intranasal inoculation into adult A/J mice, we now document that S. maltophilia strain K279a, the clinical isolate of S. maltophilia whose complete genome sequence was recently determined, is in fact capable of replicating in lungs, displaying as much as a 10-fold increase in c.f.u. in the first 8 h of infection. Importantly, as few as 104 c.f.u. deposited into the A/J lung was sufficient to promote bacterial outgrowth. Bacterial replication in the lungs of the A/J mice was followed by elevations in pro-inflammatory cytokines and also promoted resistance to subsequent challenge. We also found that DBA/2 mice were permissive for S. maltophilia K279a replication, although the level of growth and persistence in these animals was less than it was in the A/J mice. In contrast, the BALB/c and C57BL/6 mouse strains were non-permissive for S. maltophilia K279a growth. Interestingly, when five additional clinical isolates were introduced into the A/J lung, marked differences in survival were observed, with some strains being much less infective than K279a and others being appreciably more infective. These data suggest that the presence of major virulence determinants is variable among clinical isolates. Overall, this study confirms the infectivity of S. maltophilia for the mammalian host, and illustrates how both host and bacterial factors affect the outcome of Stenotrophomonas infection.

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“…The metabolic versatility of S. maltophilia (RYAN et al, 2009) allows it to colonize human urine (KONEMMAN et al, 2001), canine urine (KRALOVA-KOVARIKOVA et al, 2012), crocodile kidney (septicemia) (HARRIS; ROGERS, 2001) and buffalo liver (PETRIDOU et al, 2010). However, there is no description of its presence in the urine or feces of cattle, horses or other production animals.…”

Section: Discussionmentioning

confidence: 99%

Antifungal activity of Stenotrophomonas maltophilia in Stomoxys calcitranslarvae

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Videira

Bittencourt

et al. 2014

Rev. Bras. Parasitol. Vet.

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The microbiota present in Stomoxys calcitrans larvae may assist their survival in contaminated environments through production of inhibitory substances. Bacteriological identification methods, the polymerase chain reaction (PCR) and scanning electron microscopy (SEM) were used to detect a bacterium naturally present in mucus and macerated S. calcitrans larvae. The antifungal activity was determined based on the results from disk diffusion tests on an artificial solid medium. The bacterium was identified as Stenotrophomonas maltophilia and presented antifungal activity against Beauveria bassiana sensu lato isolates CG 138, CG 228 and ESALQ 986. This result suggests that the larval microbiota is a factor that can compromise the use of B. bassiana s.l. fungus for biological control of S. calcitrans larvae.Keywords: Stenotrophomonas maltophilia, Stomoxys calcitrans, antifungal activity. ResumoA microbiota presente em larvas de Stomoxys calcitrans pode auxiliar na sua sobrevivência em ambientes contaminados, devido à produção de substâncias inibidoras. Métodos bacteriológicos de identificação, reação em cadeia da polimerase (PCR) e microscopia eletrônica de varredura (MEV) foram utilizados para detectar uma bactéria naturalmente presente no muco e macerado de larvas de S. calcitrans. A atividade antifúngica foi baseada nos resultados obtidos no teste de difusão em meio sólido artificial. A bactéria foi identificada como Stenotrophomonas maltophilia e apresentou atividade antifúngica contra os isolados CG 138, CG 228 e ESALQ 986 de Beauveria bassiana sensu lato. Estes resultados sugerem que a microbiota larval é um fator que pode comprometer o uso de B. bassiana s.l. no controle biológico de larvas de S. calcitrans.

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The versatility and adaptation of bacteria from the genus Stenotrophomonas

Cited by 650 publications

References 151 publications

Next-Generation Bio-Products Sowing the Seeds of Success for Sustainable Agriculture

Next-Generation Bio-Products Sowing the Seeds of Success for Sustainable Agriculture

Stenotrophomonas maltophilia strains replicate and persist in the murine lung, but to significantly different degrees

Antifungal activity of Stenotrophomonas maltophilia in Stomoxys calcitranslarvae

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