The Verona diabetes study: a population-based survey on known diabetes mellitus prevalence and 5-year all-cause mortality

Muggeo, Michele; Verlato, G.; Bonora, Elena; Bressan, Federica; Girotto, Sandro; Corbellini, M.; Gemma, M. L.; Moghetti, Paolo; Zenere, M.; Cacciatori, V.; Zoppini, Giacomo; Marco, Roberto de

doi:10.1007/s001250050288

Cited by 31 publications

(41 citation statements)

References 31 publications

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“…This large multicentre study has been much criticized[65–67]. In observational studies, mortality has been reported as higher[29, 47, 48, 68–70], not influenced[27, 28, 44, 63, 71, 72] and decreased[73] in users of glucose‐lowering drugs. It is probable that raised mortality in tablet users is due to selection, but it may also be associated with an influence of sulphonylurea drugs on myocardial cells during ischaemia.…”

Section: Discussionmentioning

confidence: 99%

Relationship between blood glucose level and mortality in Type 2 diabetes mellitus: a systematic review

et al. 1999

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Aim To review the relationship between blood glucose level and mortality in patients with Type 2 diabetes mellitus (DM) as reported in the literature. for papers were: Type 2 DM; follow-up for at least 3 years; glucose or glycated haemoglobin (HbA 1c ) was used as parameter; published in the form of an article. Additionally all references in the selected articles that dealt with the relationship between blood glucose level and mortality in Type 2 DM were included in the search.Results Twenty-seven eligible articles were found. Twenty-three of them showed a positive association: measures of elevated blood glucose concentrations were associated with higher mortality; in 15 out of 23 studies the positive association was statistically signi®cant, in two only for postprandial blood glucose. One study found a nonsigni®cant negative relationship in a very old population. ConclusionIn the literature there is a positive, but rather weak, association between the measures of blood glucose control and the risk of dying of patients with Type 2 DM. In the six larger studies (more than 100 deceased patients) that used a continuous categorization of glycaemia, the Risk ratio per unit varies from 1.03 to 1.12. Diabet. Med. 16, 2±13 (1999)

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Section: Discussionmentioning

confidence: 99%

Relationship between blood glucose level and mortality in Type 2 diabetes mellitus: a systematic review

et al. 1999

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“…Although both illnesses are more common among older people, other effects predominate in the relation between disease and age. For example, the observation that the prevalence of diabetes at very advanced ages decreases (45) has also been documented in our population (46). Similarly, in hypertension, survivor effects operate so that its prevalence decreases beyond the age of 85 years (47).…”

Section: Discussionmentioning

confidence: 66%

Dynamics of Cognitive Aging: Distinguishing Functional Age and Disease from Chronologic Age in a Population

Graham

Mitnitski

Mogilner³

et al. 1999

American Journal of Epidemiology

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This paper introduces a methodological approach to the dynamics of cognitively normal (i.e., successful) aging compared with aging accompanied by different types of cognitive impairment and dementia. Using secondary analysis of a national representative database (Canadian Study of Health and Aging, 1991-1992), the authors show that the occurrence of an adverse event (symptom, sign, or disease), or the accumulation of a number of events, may be modeled as a logistic function of chronologic age in a population. In the cognitively normal, a linear relation between the logarithm of the odds of events and chronologic age was present for the majority of symptoms and signs. This regression represents the accumulation of each sign in a cognitively successful, aging population. The authors then estimated which ages for this cognitively unimpaired group correspond to the odds of the occurrence of symptoms found for a cognitively impaired population at any given chronologic age. This may be regarded as functional age, based upon the accumulation of a particular functional deficit in the impaired population, analogous to the concept of frailty. The dynamics of aging are a complex process of accumulation of deficits (morbidity), whereby decline from some previously healthy level of synergistically associated symptoms and signs results in distinct patterns of disease and staging. The modeling of these dynamics takes us a step further toward the definition and refinement of disease and normal aging.

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“…To note, metabolic control and diabetic treatment didn't show any significant prognostic value, while diabetes length was significant only at univariate analysis: previous works that recognized a significant role for these parameters involved differently selected populations [13][14][15] and a longer and more detailed assessment of glycemic control [16]. It is conceivable that a good metabolic control is essential in preventing complications; it loses its prognostic significance once a macrovascular complication becomes clinically evident in a diabetic patient, considering the frequent late clinical presentation and the global worse prognosis.…”

Section: Prognostic Value Of Clinical Variablesmentioning

confidence: 58%

Prognostic value of dobutamine stress echocardiography in diabetic patients

Innocenti

Agresti

Baroncini

et al. 2010

Int J Cardiovasc Imaging

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CAD is the main cause of morbidity and mortality in diabetic patients; we need reliable clinical parameters to stratify cardiovascular risk in these patients. We thus assessed prognostic value of clinical parameters, rest and stress echocardiographic data in diabetic patients, with known or suspected CAD. We studied 322 type 2 diabetic patients, who underwent dobutamine stress echocardiography (DSE) for known or suspected CAD; for prognostic assessment, end-points were all-cause mortality and hard cardiac events (cardiac death and non fatal myocardial infarction). During DSE, viability and inducible ischemia developed in 65 (20%) and 192 (60%) subjects, respectively; a severe ischemia (an asynergic area including more than 40% of all segments combined with a rate pressure product< 17,000) appeared in 88 (27%). Presence of a diabetic treatment or microvascular diabetic complications didn't influence prognosis, while a longer diabetes duration was associated with a higher all-cause mortality at univariate analysis. At multivariate analysis, an advanced age (RR = 1.108, CI: 1.039-1.182, P = 0.002), a lower left ventricular ejection fraction (RR = 0.956, CI: 0.919-0.994, P = 0.025) and, tendentially, peripheral vascular disease (RR = 2.942, CI: 0.985-8.785, P = 0.053) independently determined an increased all-cause mortality. New hard cardiac events occurred more frequently in presence of peripheral vascular disease (RR = 2.975, CI: 1.339-6.608, P = 0.007), viability (RR = 3.427, CI: 1.400-8.390, P = 0.007) and severe ischemia (RR = 3.245, CI: 1.503-7.005, P = 0.003). In diabetic patients with known or suspected CAD, presence of viability and severe ischemia during DSE are independently associated with higher occurrence of hard cardiac events.

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The Verona diabetes study: a population-based survey on known diabetes mellitus prevalence and 5-year all-cause mortality

Cited by 31 publications

References 31 publications

Relationship between blood glucose level and mortality in Type 2 diabetes mellitus: a systematic review

Relationship between blood glucose level and mortality in Type 2 diabetes mellitus: a systematic review

Dynamics of Cognitive Aging: Distinguishing Functional Age and Disease from Chronologic Age in a Population

Prognostic value of dobutamine stress echocardiography in diabetic patients

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