The ventricular ectopic QRS interval (VEQSI): Diagnosis of arrhythmogenic right ventricular cardiomyopathy in patients with incomplete disease expression

Bastiaenen, Rachel; Pantazis, Antonis; Gonna, Hanney; Ster, Irina Chis; Castelletti, Silvia; Batchvarov, Velislav N.; Domenichini, Giulia; Coccolo, Fabio; Boriani, Giuseppe; McKenna, William J.; Behr, Elijah R.; Gallagher, Mark M.

doi:10.1016/j.hrthm.2016.03.039

Cited by 13 publications

(2 citation statements)

References 22 publications

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“…This trial showed that ICD therapy is clearly superior to medical therapy alone in patients who have survived a cardiac arrest. We have attributed this patient’s cardiac arrest to the underlying arrhythmia because of the lack of any evidence of any other cardiac condition after the extensive investigations listed and the short VEQSI recorded [ 5 , 6 ]. We consider it extremely unlikely to have been due to pro-arrhythmia related to the use of verapamil based on the lack of clinical evidence of such a pro-arrhythmic effect, the laboratory evidence against the existence of such an effect [ 7 ], and the lack of any pro-arrhythmic effect on the Holter monitoring of this patient between the time of initiation of verapamil therapy and the occurrence of the cardiac arrest.…”

Section: Discussionmentioning

confidence: 99%

Ventricular fibrillation treated by cryotherapy to the right ventricular outflow tract: a case report

et al. 2016

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BackgroundArrhythmias originating from the right ventricular outflow tract are generally considered benign but cases of cardiac arrest have been described, usually associated with polymorphic ventricular tachycardia or extrasystoles with short coupling intervals.Case presentationWe report the case of a 54-year-old Caucasian woman with symptomatic right ventricular outflow tract arrhythmias without structural heart disease who suffered a ventricular fibrillation arrest without prior malignant clinical features. Cryoablation was performed and an implantable cardioverter defibrillator was implanted. She has since been free of arrhythmia for 7 years and has asked that the implantable cardioverter defibrillator not be replaced when the battery becomes depleted.ConclusionsAlthough usually benign, right ventricular outflow tract tachycardia can be life-threatening. Even the most malignant cases can be cured by ablation.

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Section: Discussionmentioning

confidence: 99%

Ventricular fibrillation treated by cryotherapy to the right ventricular outflow tract: a case report

et al. 2016

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“…Data suggest that VA with broader QRS, increasing notching and axis <30° are highly suggestive of ARVC. [55][56][57][58] CMR has an important role for identification of phenocopies including DCM, cardiac sarcoid and RV volume overload. 59 Left dominant ARVC may mimic DCM but frequent arrhythmias and subepicardial LGE on CMR favour ARVC diagnosis.…”

Section: Differential Diagnosesmentioning

confidence: 99%

Arrhythmogenic Right Ventricular Cardiomyopathy: From Pathophysiology to Diagnosis and Advances in Management

2017

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Our understanding of arrhythmogenic right ventricular cardiomyopathy (ARVC) has advanced considerably over the past 30-40 years. This is an inherited cardiomyopathy with complicated genetic inheritance and variable penetrance. Desmosomal dysfunction underlies most cases, and appreciating this pathophysiology has contributed to patient management, particularly with respect to exercise restriction to reduce disease progression. The diagnosis is made according to a series of Task Force Criteria, and subsequent management is guided by expert consensus in the absence of comparative data. ARVC is associated with sudden cardiac death (SCD), particularly in young athletic individuals who unknowingly harbour the condition. Risk stratification is important to guide implantable cardioverter-defibrillator use and reduce SCD. Residual gaps in our understanding, particularly surrounding incomplete penetrance, the underlying pathophysiology and risk stratification, are being targeted by collaborative efforts, large registries, prospective studies and translational research.

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Improvement in Diagnosis of Sudden Cardiac Death

Gao

Zhang

et al. 2020

Sudden Death

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The ventricular ectopic QRS interval (VEQSI): Diagnosis of arrhythmogenic right ventricular cardiomyopathy in patients with incomplete disease expression

Abstract: Background

Cited by 13 publications

References 22 publications

Ventricular fibrillation treated by cryotherapy to the right ventricular outflow tract: a case report

Ventricular fibrillation treated by cryotherapy to the right ventricular outflow tract: a case report

Arrhythmogenic Right Ventricular Cardiomyopathy: From Pathophysiology to Diagnosis and Advances in Management

Improvement in Diagnosis of Sudden Cardiac Death

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