The ventricular-brain ratio using planimetric measurement of EMI scans

Synek, V; Reuben, J. R.

doi:10.1259/0007-1285-49-579-233

Cited by 180 publications

(36 citation statements)

References 7 publications

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“…63,64 The two major methods to control for intersubject variation in head size are division of the region of interest by total intracranial volume 67 or division by whole brain volume. 1 Free et al 72 investigated several control regions for their relationship to hippocampal volume, including the corpus callosum, the cranial area, parenchymal area on midsagittal sections, the area of the brain stem on an axial section, and cranial volume and cerebral volume taken from nine coronal sections throughout the cerebrum.…”

Section: Discussionmentioning

confidence: 99%

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MR-based in vivo hippocampal volumetrics: 1. Review of methodologies currently employed

2004

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The advance of neuroimaging techniques has resulted in a burgeoning of studies reporting abnormalities in brain structure and function in a number of neuropsychiatric disorders. Measurement of hippocampal volume has developed as a useful tool in the study of neuropsychiatric disorders. We reviewed the literature and selected all English-language, human subject, data-driven papers on hippocampal volumetry, yielding a database of 423 records. From this database, the methodology of all original manual tracing protocols were studied. These protocols differed in a number of important factors for accurate hippocampal volume determination including magnetic field strength, the number of slices assessed and the thickness of slices, hippocampal orientation correction, volumetric correction, software used, inter-rater reliability, and anatomical boundaries of the hippocampus. The findings are discussed in relation to optimizing determination of hippocampal volume.

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Section: Discussionmentioning

confidence: 99%

“…63,64 Hippocampal volumes should thus be corrected for intersubject variation in head size. Correcting for head-size or whole brain volume introduces two separate sources of error and thus produces measures with lower reliability.…”

Section: Image Processingmentioning

confidence: 99%

MR-based in vivo hippocampal volumetrics: 1. Review of methodologies currently employed

2004

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“…The coefficient of variance in our measurements of VBR was ±4.7% in the present study. The VBR has been previously demonstrated to be an acceptable index of whole brain cortical atrophy [1, 27, 28, 29]; an increase in VBR indicates progression of whole brain cortical atrophy.…”

Section: Methodsmentioning

confidence: 99%

Dialysis-Related Hypotension as a Cause of Progressive Frontal Lobe Atrophy in Chronic Hemodialysis Patients: A 3-Year Prospective Study

et al. 2004

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Background/Aim: Brain atrophy is known to develop more rapidly in hemodialysis (HD) patients than other individuals. The present study was designed to examine the role of HD-related hypotension in brain atrophy in patients on chronic HD. Methods: By using magnetic resonance imaging, whole brain atrophy was assessed by the ventricular-brain ratio (VBR; ventricular area/whole brain area). Frontal brain atrophy was assessed by the frontal atrophy index (FAI; frontal brain area/intracranial frontal space). The number of lacunae was also counted. We studied 32 HD patients without symptomatic neurological abnormalities or diabetes mellitus: male/female ratio 19/13; mean age ± SD 53 ± 10 (range 28–77) years; mean HD duration ± SD 11 ± 6 (range 1–22) years. Magnetic resonance imagings were taken in 1995 and 1998. All dialysis-related hypotension episodes during the same period were identified from the medical records and counted. Results: The VBR ranged from 8.8 to 18.7% in 1995 (12.8 ± 2.2%) and was not different in 1998 (13.1 ± 2.7%). However, the VBR increased by more than 5% in 14 patients, and their HD duration of 13 ± 6 years was significantly longer than that of 18 patients with stable VBR (p < 0.05). The FAI in 1995 was 62.2 ± 4.2% (range 55.8–71.3%) and decreased significantly to 59.7 ± 4.7% (range 50.2–70.9%) in 1998 (p < 0.05). The change in FAI correlated significantly with both the total number of dialysis-related hypotension episodes (r = 0.45, p < 0.05) and the increase in number of lacunae (r = 0.42, p < 0.05). Conclusion: Our results suggest that dialysis-related hypotension plays a role in progressive frontal lobe atrophy in HD patients.

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“…An area measurement, the ventricle brain ratio [2] was calculated from the ventricular area divided by the total brain area at the level of the body of the lateral ventricles. Linear measurements of ventricles and skull were made from the scans using digital calipers.…”

Section: Methodsmentioning

confidence: 99%

Frontal and Occipital Horn Ratio: A Linear Estimate of Ventricular Size for Multiple Imaging Modalities in Pediatric Hydrocephalus

O'Hayon¹,

Drake²,

Ossip³

et al. 1998

Pediatr Neurosurg

285

168

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Objective: Measurement of ventricular size is important in pediatric patients with hydrocephalus, especially those who are being followed with cerebrospinal fluid (CSF) shunts. While volumetric techniques are a more accurate estimate of true ventricular volume, they are often impracticable when multiple modalities including ultrasound are used. Volumetric area and linear measurements were compared to find the most reasonable measurement method. Methods: Sixty-four computed tomography (CT), magnetic reasonance imaging (MRI), and ultrasound (US) scans from 25 children aged 0–17 years with hydrocephalus, before and after treatment, were measured. Measurements included ventricular volume, a ventricular/brain ratio, and four standard linear measures (Evans’ ratio, Huckman’s measurement, minimal lateral ventricular width, and lateral ventricular span at the body). We also included a new ratio, which accounts for often disproportionate occipital horn expansion in pediatric patients, called the frontal and occipital horn ratio. Volume and linear measurements were compared using the Spearman’s correlation coefficients and correlations were further differentiated using a Z test statistic. The frontal and occipital horn ratio was also measured on CT, MRI, and US scans from 44 normal children aged 0–17 years to identify normal values. The effect of age was determined by linear regression. Results: The best linear correlation with ventricular size was the frontal + occipital horn ratio (r = 0.852) and was equivalent to the ventricular/brain ratio (r = 0.891), previously shown to have the highest correlation with ventricular volume. Evans’ ratio correlates less well (r = 0.423). The normal frontal and occipital horn ratio is 0.37 and is independent of age. Conclusions: The frontal and occipital horn ratio is a simple method of evaluating ventricular size in pediatric hydrocephalus patients with CSF shunts.

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The ventricular-brain ratio using planimetric measurement of EMI scans

Cited by 180 publications

References 7 publications

MR-based in vivo hippocampal volumetrics: 1. Review of methodologies currently employed

MR-based in vivo hippocampal volumetrics: 1. Review of methodologies currently employed

Dialysis-Related Hypotension as a Cause of Progressive Frontal Lobe Atrophy in Chronic Hemodialysis Patients: A 3-Year Prospective Study

Frontal and Occipital Horn Ratio: A Linear Estimate of Ventricular Size for Multiple Imaging Modalities in Pediatric Hydrocephalus

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