The vasodilatory effect of ketamine is independent of the N-methyl-D-aspartate receptor: lack of functional N-methyl-D-aspartate receptors in rat mesenteric artery smooth muscle

Noh, Hyun Ju; Bae, Young Min; Park, Seung H.; Kim, Jae Gwan; Kim, Yoon S; Kim, Seong H.; Cho, Sung-Il; Woo, Nam Sik

doi:10.1097/eja.0b013e32832a1704

Cited by 11 publications

(12 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is in line with EEG studies that have demonstrated increases in highfrequency and decreases in low-frequency neural oscillations in humans (80) and in mice (81). In addition, resting-state positron emission tomography studies have demonstrated that ketamine-induced increase in regional blood flow is counterintuitively associated with reduced oxygen extraction (82,83), possibly related to the direct vascular effect of ketamine (84).…”

Section: P100 Effectsupporting

confidence: 85%

Effects of Acute Ketamine Infusion on Visual Working Memory: Event-Related Potentials

Koychev

Deakin

El‐Deredy

et al. 2017

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

View full text Add to dashboard Cite

This is the accepted version of the paper.This version of the publication may differ from the final published version. ABSTRACT BACKGROUND: Working memory (WM) deficits are a core feature of schizophrenia. Electrophysiological studies suggest that impaired early visual processing may contribute to impaired WM in the visual domain. Abnormal N-methyl-D-aspartate (NMDA) receptor function has been implicated both in WM and in early visual processing deficits in schizophrenia. We investigated whether ketamine, a noncompetitive NMDA antagonist, would replicate in healthy volunteers the WM performance and early visual processing abnormalities we and others have reported in patients with schizophrenia. METHODS: Forty-four healthy volunteers were randomly assigned to receive intravenous ketamine or placebo. During infusion, the effects of ketamine were recorded using standardized psychiatric scales. Visual evoked potentials (P100 and P300 components) were recorded during performance of a delayed matching to sample task. RESULTS: Ketamine induced mild psychosis-like symptoms and impaired WM performance. It also significantly increased the P100 amplitude, while P300 amplitude decreased in a load-dependent manner. Amplitudes of P100 during retrieval correlated with cognitive performance only in the placebo group. CONCLUSIONS: We confirmed previous studies showing that ketamine reproduces the impairment of WM performance and smaller P300 amplitudes observed in schizophrenia. However, ketamine increased visual P100 amplitude in contrast to our observation of reduced P100 amplitudes in established schizophrenia. The effects of ketamine on WM and P300 are likely to involve impaired NMDA function, as these receptors are implicated in changes of synaptic strength underlying associative learning and memory. Increased P100 amplitude may reflect the secondary disinhibition of cortical glutamate release that occurs after NMDA blockade. Permanent repository link

show abstract

Section: P100 Effectsupporting

confidence: 85%

Effects of Acute Ketamine Infusion on Visual Working Memory: Event-Related Potentials

Koychev

Deakin

El‐Deredy

et al. 2017

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

View full text Add to dashboard Cite

show abstract

“…The Institutional Animal Care and Use Committee of Konkuk University approved this study. Mesenteric arterial rings were prepared as previously described [16]. Male Sprague-Dawley (SD) rats (10- to 11-week-old) were exsanguinated by cutting the carotid arteries under deep ketamine-xylazine anesthesia or after exposure to rising concentrations of carbon dioxide.…”

Section: Methodsmentioning

confidence: 99%

“…The isometric tension of arterial rings was measured as previously described [16]. The arterial rings were mounted vertically on two L-shaped stainless steel wires in a 3 mL tissue chamber.…”

Section: Methodsmentioning

confidence: 99%

Facilitation of serotonin-induced contraction of rat mesenteric artery by ketamine

Park

Noh

Kim

et al. 2016

Korean J Physiol Pharmacol

Self Cite

View full text Add to dashboard Cite

Ketamine is an anesthetic with hypertensive effects, which make it useful for patients at risk of shock. However, previous ex vivo studies reported vasodilatory actions of ketamine in isolated arteries. In this study, we reexamined the effects of ketamine on arterial tones in the presence and absence of physiological concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) by measuring the isometric tension of endothelium-denuded rat mesenteric arterial rings. Ketamine little affected the resting tone of control mesenteric arterial rings, but, in the presence of 5-HT (100~200 nM), ketamine (10~100 µM) markedly contracted the arterial rings. Ketamine did not contract arterial rings in the presence of NE (10 nM), indicating that the vasoconstrictive action of ketamine is 5-HT-dependent. The concentration-response curves (CRCs) of 5-HT were clearly shifted to the left in the presence of ketamine (30 µM), whereas the CRCs of NE were little affected by ketamine. The left shift of the 5-HT CRCs caused by ketamine was reversed with ketanserin, a competitive 5-HT2A receptor inhibitor, indicating that ketamine facilitated the activation of 5-HT2A receptors. Anpirtoline and BW723C86, selective agonists of 5-HT1B and 5-HT2B receptors, respectively, did not contract arterial rings in the absence or presence of ketamine. These results indicate that ketamine specifically enhances 5-HT2A receptor-mediated vasoconstriction and that it is vasoconstrictive in a clinical setting. The facilitative action of ketamine on 5-HT2A receptors should be considered in ketamine-induced hypertension as well as in the pathogenesis of diseases such as schizophrenia, wherein experimental animal models are frequently generated using ketamine.

show abstract

“…La respuesta hiper tensiva no parece estar relacionada a estos receptores NMDA, ni centrales ni periféricos. En estos últimos, experi mentalmente en arterias mesentéricas in vitro de rata, la ketamina actúa pro duciendo más bien vasodilatación (29) , mecanismo no esperado en la respuesta hipertensiva y que es independiente de los receptores NMDA que no parecen ser funcionales en la estructura muscu lar lisa mesentérica.…”

Section: Discussionunclassified

Modificaciones en la presión arterial y el pulso por ketamina, con y sin succinilcolina

Álvarez-Falconí

Céspedes³

2013

An Fac med

View full text Add to dashboard Cite

ResumenIntroducción: La ketamina es utilizada como anestésico general, de inducción y como analgésico. Objetivos: Evaluar los cambios en la presión arterial sistólica (PAS), diastólica (PAD) y frecuencia del pulso (FP) producidos por la ketamina, y la influencia de la succinilcolina. Diseño: Comparativo y de observación. Institución: Clínica Maison de Santé, Lima, Perú. Participantes: Pacientes que recibieron ketamina. Intervenciones: La ketamina fue empleada como anestésico general único y de inducción. Por cada modalidad, se consideró doce pacientes. Los doce primeros recibieron ketamina 2 mg/kg endovenosa, con medición de la PAS, PAD y FP antes y después de la anestesia. Los otros doce recibieron ketamina más succinilcolina, midiéndose los parámetros antes y después. Se comparó los cambios. Principales medidas de resultados: Variaciones en la PAS, PAD y FP. Resultados: En los primeros doce pacientes, la ketamina elevó la PAS 26 ± 3 mmHg, p < 0,001, la PAD 19 ± 3 mmHg, p < 0,001, y la FP 15 ± 3 por minuto, p < 0,001. En los otros doce, la ketamina más succinilcolina elevaron la PAS 28 ± 3 mmHg, p < 0,001, la PAD 18 ± 2 mmHg, p < 0,001 y la FP 13 ± 1 por minuto, p < 0,001. Comparándolos porcentualmente, la succinilcolina no afectó esos cambios. Conclusiones: El incremento de la presión arterial y pulso producidos por la ketamina no fueron afectados por la succinilcolina. Palabras clave: Ketamina, succinilcolina, anestesia, presión arterial, pulso. Abstract Introduction: Ketamine is used as a general anesthetic as well as for anesthesia induction and analgesia. Objectives: To assess modifications in systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) caused by ketamine, and if there is any influence of succinylcholine. Design: Comparative and observational study. Setting: Maison de Santé Clinic, Lima, Peru. Participants: Patients receiving ketamine. Interventions: Ketamine was used as a single drug for general anesthesia and for induction. Twelve patients were considered for each modality. The twelve first patients received ketamine, 2 mg/kg IV, and SBP, DBP and HR were measured before and after administering the drug. The second group received ketamine plus succinylcholine, and same parameters were measured. Main outcome measures: SBP, DBP, and HR variations. Results: Following ketamine injection in the first twelve patients there were elevations in SBP 26 ± 3 mmHg, p < 0,001, DBP 19 ± 3 mmHg, p < 0,001, and HR 15 ± 3 per minute, p < 0,001. In the second group after ketamine plus succinylcholine administration there were increases in SBP 28 ± 3 mmHg, p < 0,001, DBP 18 ± 2 mmHg, p < 0,001, and HR 13 ± 1 per minute, p < 0,001. There were no statistically significant differences when comparing both groups, i.e. succinlycholine did not have any influence in modifying the aforementioned parameters. Conclusions: Increases in blood pressure and heart rate induced by ketamine were not affected by succinylcholine.

show abstract

The vasodilatory effect of ketamine is independent of the N-methyl-D-aspartate receptor: lack of functional N-methyl-D-aspartate receptors in rat mesenteric artery smooth muscle

Abstract: These results suggest that the NMDAr is not functional in vascular smooth muscle, and the vasodilatory action of ketamine is independent of the NMDAr in the rat mesenteric artery.

Cited by 11 publications

References 26 publications

Effects of Acute Ketamine Infusion on Visual Working Memory: Event-Related Potentials

Effects of Acute Ketamine Infusion on Visual Working Memory: Event-Related Potentials

Facilitation of serotonin-induced contraction of rat mesenteric artery by ketamine

Modificaciones en la presión arterial y el pulso por ketamina, con y sin succinilcolina

Contact Info

Product

Resources

About