The Vasculature of Xenotransplanted Human Melanomas and Sarcomas on Nude Mice

Abstract

The vascular system of xenotransplanted human melanomas and sarcomas on nude mice was studied by means of microcorrosion casting. In summary, the vascular system of xenotransplants can be described in termes of a simply structured system, lacking not only a hierarchy with respect to wall formation but also to vascular distribution. Thus, the vasculature clearly differs from that in normal tissues.

A novel combretastatin A-4 derivative, AC7700, strongly stanches tumour blood flow and inhibits growth of tumours developing in various tissues and organs

“…Tumour vessels, even large-calibre vessels, usually consist of only a monolayer of endothelial cells and have no pericytes or smooth muscle cells for a supporting structure; sometimes a basement membrane cannot be observed at all or only incompletely (Papadimitriou and Woods, 1975;Konerding et al, 1989). Normal vessels, in contrast, are usually supported by pericytes and a continuous basement membrane (Simionescu and Simionescu, 1984).…”

pH in human tumour xenografts: effect of intravenous administration of glucose

“…The histomorphology of tumour xenografts does not always mirror the tissue architecture of primary tumours. In general, however, the vasculature of xenografted human tumours bears a high degree of resemblance in morphology as well as functional properties to the vascular network of primary tumours in situ (Vaupel et al, 1987;Konerding et al, 1989a;Konerding et al, 1989b). It may thus be reasonably assumed that primary tumours will exhibit a similar pH response to glucose as their xenograft counterparts.…”

Vasculogenic Mimicry: How Convincing, How Novel, and How Significant?

“…Warren 39 included "blood vessels without endothelial lining" among his nine categories of tumor vessels. In 1989, Konerding et al 42 used the term endothelial imitation to describe the role of tumor cells in the formation of vascular channels. This concept has been addressed in reviews on tumor blood flow 43,44 and in a textbook of general pathology.…”