The Vascularization of the Heart Valves: A Comparative Study

Durán, Carlos M.G.; Gunning, A. J.

doi:10.1093/cvr/2.3.290

Cited by 20 publications

(12 citation statements)

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“…It is therefore reasonable to emphasize the biological difference between a fresh or freeze-dried aortic wall and an aortic valve cusp. The latter does not seem to need any intrinsic vascularization which, as we have shown elsewhere, is not normally present (Duran and Gunning, 1968). This fact might explain the difference between the bad results observed with arterial grafts in peripheral vascular surgery and the good results to date with valve grafts.…”

Section: Histologysupporting

confidence: 56%

Implantation of homologous and heterologous aortic valves in prosthetic vascular tubes : An experimental study

Durán¹,

Whitehead²,

Gunning³

1969

Thorax

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TECHNIQUEThe pig aortic valves were obtained unsterile from the slaughter-house within 12 hours after the animal was sacrificed, the hearts having been kept in a refrigerated chamber. The dog aortic valves were collected immediately after death in the research laboratories. All specimens were kept in sterile jars in Hanks' solution (Gross, Bill, and Peirce, 1949) in a commercial refrigerator for the final dissection. This period of storage never exceeded eight days, the majority being stored for only 24 hours. The aortic valves were then trimmed so that only a few millimetres of aortic wall remained above, and a small cuff of myocardium and mitral valve below, the insertion of the cusps. The valve was then sutured into a Teflon3 or Dacron' vascular tube and the whole was sterilized by immersion in liquid ethylene oxide for 30 minutes and subsequently freeze dried and stored in a vacuum. At the time of the insertion the valves were reconstituted by immersion in warm saline for 20 minutes.The dogs were anaesthetized with intravenous nembutal, and the trachea was intubated and ventilated with a Starling's respirator. A left thoracotomy through the fourth intercostal space was performed and a segment of descending thoracic aorta was dissected out. A left sub-clavian artery/left femoral artery bypass was used with a siliconized 4 mm.

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Section: Histologysupporting

confidence: 56%

Implantation of homologous and heterologous aortic valves in prosthetic vascular tubes : An experimental study

Durán¹,

Whitehead²,

Gunning³

1969

Thorax

Self Cite

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“…In human and canine hearts numerous arterial connections exist, the majority in the epicardium and endocardium surfaces in which, this last, is related to the papillary vases and trabeculas in great number 6 . We find anastomoses between coronary artery, its branches and subsegments, located on the pericardium surface, in the intramuscular pathway and in the endocardium, in accordance to the results of other authors 3,5,30 , as well as abundant anastomosis in the region of the papillary muscles 3,5,6,8,9,10,12,16,27 . Some authors report a constant presence of two papillary muscles on the left ventricle of the man, to whom sanguine suppliment has multiple origins.…”

Section: Results Discussion and Conclusionsupporting

confidence: 92%

Irrigação dos músculos papilares do ventrículo esquerdo do coração de caninos (Canis familiaris, L. 1758)

Lourenço

Dio

Souza

et al. 2007

Braz. J. Vet. Res. Anim. Sci.

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The irrigation of the papillary muscles, has incomplete information on the distribution of the arterial vessels. Objectifying to establish the origin of these arteries and their distribution in the left ventricle papillary muscles, we used 30 hearts of adult, male and female mongrel dogs. After the death, the heart was removed, washed and injected through the left coronary artery opening with an acetate solution of stained vinyl, neoprene latex 650 colored or 10% gelatin. The papillary muscles in all the applied techniques had been fixed with 10% formaldehyde solution. The dissection was carried out with the aid of a 40% sulfuric acid solution. For accomplishment of the radiography, we used mercury injection what assisted the assembly of the studied vascularization projects. Clearing technique of Spalteholz was applied for better visualization of the cardiac irrigation. We evidenced that the subauricular and subatrial papillary muscles are irrigated by the left coronary artery branches. The subauricular papillary muscle was blood-supplied by the interventricular paraconal and circumflex branches and the subatrial papillary muscle mainly by the circumflex branch. The sub-segments that supply the subauricular papillary muscle from the interventricular paraconal branch are the left collateral and ventricular branches and from the circumflex branch: left dorsal branches and intermedial (left ventricular marginal) and rarely from the left ventricular ridge (diaphragmatic branch). The subsegments of the circumflex branch that supply the subatrial papillary muscle are: intermedial (left ventricular marginal), from the left ventricular ridge (diaphragmatic branch), right dorsal branches and subsinuous interventricular branch. In some cases we observed the collateral branch and the proper interventricular paraconal branch reaching the portion of the vertex of the subatrial papillary muscle.

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“…(For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.) Gunning, 1968). It may be that in young tissue engineered valves, spatio-temporal control of angiogenesis would encourage rapid host integration allowing the tissue to grow with the patient.…”

Section: Discussionmentioning

confidence: 99%

“…Studies showing that CAVD involves endochondral bone formation (Xu et al, 2010) -a process that, in normal bone, requires neovascularization (Ishijima et al, 2012) -also supports investigating the inhibition of functional neovessel formation as a treatment for CAVD. Interestingly, normal pediatric heart valves (unlike normal adult valves) are richly vascularized (Duran and Gunning, 1968), which suggests that vascularization may be an important factor to consider in the tissue engineering of heart valves for pediatric patients. All in all, there is compelling evidence for further characterization of vasculogenic behavior by heart valve cells.…”

Section: Introductionmentioning

confidence: 99%

Regulation of valve endothelial cell vasculogenic network architectures with ROCK and Rac inhibitors

Arevalos

Walborn

Rupert

et al. 2015

Microvascular Research

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The Vascularization of the Heart Valves: A Comparative Study

Cited by 20 publications

References 0 publications

Implantation of homologous and heterologous aortic valves in prosthetic vascular tubes : An experimental study

Implantation of homologous and heterologous aortic valves in prosthetic vascular tubes : An experimental study

Irrigação dos músculos papilares do ventrículo esquerdo do coração de caninos (Canis familiaris, L. 1758)

Regulation of valve endothelial cell vasculogenic network architectures with ROCK and Rac inhibitors

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