The Vascular Wall State and Microcirculation Parameters in Patients with Controlled and Uncontrolled Arterial Hypertension

Подзолков, В. И.; Брагина, А. Е.; Natkina, D.; Сафронова, Т. А.; Nebieridze, N.; Podshibyakina, E. V.

doi:10.20996/1819-6446-2019-15-4-495-501

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…Хорошо известно, что низкая приверженность к терапии является предиктором развития неконтролируемой АГ, гипертонических кризов, сердечно-сосудистых событий, ХБП [8]. При несоблюдении режима лечения и неконтролируемом течении продемонстрировано повышение жесткости сосудистой стенки, развитие гипертрофии левого желудочка (ГЛЖ), микроальбуминурии и когнитивной дисфункции [10,11]. Помимо этого, существует широкий спектр социальных последствий неприверженности к терапии: снижение качества жизни, повышение частоты обращаемости за медицинской помощью, потребности в госпитализации и уровня инвалидизации, а также ограничение работоспособности и возможностей самообслуживания [8].…”

Section: ключевые моменты что известно о предмете исследования?unclassified

Compliance to treatment and its role in solving the problem of uncontrolled hypertension

Podzolkov,

Bragina,

Medvedev

et al. 2023

Cardiovasc Ther Prev

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Failure to achieve blood pressure targets and insufficient control are important cardiology problems that remain relevant despite well-defined and generally available modern algorithms for the treatment of hypertension (HTN) and the availability of effective antihypertensive drugs. The level of hypertension control in Russia remains quite low and is 14,1% for men and 30,9% for women. The generally recognized most important factor determining the low blood pressure control is non-compliance with antihypertensive therapy, which, in turn, determines the high percentage of uncontrolled HTN among patients. The review discusses the most common causes of low adherence to treatment. Particular attention is paid to the doctor’s ability to remove barriers to adherence and errors in the choice of therapy, including insufficient prescribing of fixed-dose combinations. The review presents a modern view on the significance of combined antihypertensive therapy. Attention is focused on fixed-dose combinations of antihypertensives, the use of which significantly increases adherence to therapy, and the unique properties and effectiveness of lisinopril, amlodipine and indapamide are described.

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Section: ключевые моменты что известно о предмете исследования?unclassified

Compliance to treatment and its role in solving the problem of uncontrolled hypertension

Podzolkov,

Bragina,

Medvedev

et al. 2023

Cardiovasc Ther Prev

Self Cite

View full text Add to dashboard Cite

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Photoplethysmography factors associated with undiagnosed hypertension in men with low and moderate cardiovascular risk

Korolev,

Fedorovich,

Gorshkov

et al. 2023

Cardiovasc Ther Prev

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Aim. To study the functional state of the terminal arteries and arterioles of the skin using photoplethysmography (PPG) in men with hypertension (HTN) of low and moderate cardiovascular risk (CVR) and to identify morphofunctional diagnostic criteria associated with HTN.Material and methods. A total of 118 healthy men (30-60 years old) underwent clinical and biochemical blood tests, PPG, ultrasound of cardiac and main arteries, 24-hour blood pressure monitoring. According to 24-hour blood pressure monitoring, two groups were formed: the control group — 59 normotensive men, HTN group — 59 men with HTN.Results. According to the PPG data, men with HN had higher normalized augmentation index (Alp75) (3,8 and -5,25%; (p<0,005)), stiffness index (SI) (7,6 and 7,35 m/s) (p<0,05) and reflection index (RI) (36,5 and 28,4%) (p<0,005), respectively. According to multivariate analysis, an increase in RI ≥30,6% (odds ratio, 4,6; p=0,0476) and SI ≥7,9 m/s (odds ratio, 3,69; p=0,019) was significantly associated with HTN. A regression model has been developed that includes age ≥35 years, RI ≥30,6% and SI ≥7,9 m/s, which allows predicting HTN in men with low and moderate cardiovascular risk with a sensitivity of 78% and a specificity of 62,1%.Conclusion. Men with HTN of low and moderate CVR are characterized by an increase in vascular stiffness, tone of smooth muscle cells, terminal muscular arteries and arterioles, and an increase in pulse wave velocity. The developed model can be used to predict hypertension in these patients and determine indications for further examination.

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The Vascular Wall State and Microcirculation Parameters in Patients with Controlled and Uncontrolled Arterial Hypertension

Cited by 2 publications

References 17 publications

Compliance to treatment and its role in solving the problem of uncontrolled hypertension

Compliance to treatment and its role in solving the problem of uncontrolled hypertension

Photoplethysmography factors associated with undiagnosed hypertension in men with low and moderate cardiovascular risk

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