The vascular phenotype of children with systemic lupus erythematosus

Quinlan, Catherine; Kari, Jameela A.; Pilkington, Clarissa; Deanfield, John; Shroff, Rukshana; Marks, Stephen D.; Tullus, Kjell

doi:10.1007/s00467-015-3059-9

Cited by 13 publications

(10 citation statements)

References 49 publications

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“…In addition, the study of Yildiz et al 34 found higher aortic PWV in 24 premenopausal women with SLE compared with 24 age- and sex-matched controls. However, both the study by Tziomalos et al 16 (including 55 patients with SLE and 61 controls) and the study by Quinlan et al 30 (including 45 patients with SLE and 40 controls) found that PWV did not differ between patients with SLE and controls.…”

Section: Discussionmentioning

confidence: 89%

“…The basic characteristics of the selected studies are summarized in Table 1. [16][17][18][19][25][26][27][28][29][30][31][32][33][34] In 9 studies, patients were diagnosed with SLE by the American College of Rheumatology (ACR) classification criteria, whereas the other 5 studies did not mention the diagnostic criteria. The age, sex, and BMI were matched between patients with SLE and controls in each included study.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Increased Pulse Wave Velocity in Systemic Lupus Erythematosus: A Meta-Analysis

et al. 2017

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Systemic lupus erythematosus (SLE) is associated with increased cardiovascular risk. This study aims to derive a more precise estimation on pulse wave velocity (PWV) level in patients with SLE and related factors. A literature search was performed using PubMed, EMBASE, and The Cochrane Library databases, studies published up to February 28, 2017, in English. Pooled standardized mean difference (SMD) with 95% confidence interval (CI) was calculated by fixed-effect or random-effect model analysis. Heterogeneity test was performed by the Q statistic and quantified using I; publication bias was evaluated using a funnel plot and Egger's linear regression test. Of 156 studies found, 27 met eligibility criteria, and 14 studies were finally included in the meta-analysis. Meta-analysis revealed that the SLE group had significantly higher PWV levels than the control group; SMD = 0.56 and 95% CI (0.30-0.82). Subgroup analyses showed that body mass index (BMI), sample size, and disease duration were associated with PWV in patients with SLE. Overall, our study suggests that patients with SLE have a higher PWV level, and it is associated with BMI, sample size, and disease duration.

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Section: Discussionmentioning

confidence: 89%

Section: Study Characteristicsmentioning

confidence: 99%

Increased Pulse Wave Velocity in Systemic Lupus Erythematosus: A Meta-Analysis

et al. 2017

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“…left ventricular hypertrophy, increased carotid artery intima-media thickness, and pulse wave velocity) despite relatively short disease duration. 28–30…”

Section: Discussionmentioning

confidence: 99%

Blood pressure control over time in childhood-onset systemic lupus erythematous

Avar-Aydın

Shan

Brunner

et al. 2018

Lupus

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Introduction Hypertension (HTN) is prevalent in patients with systemic lupus erythematosus (SLE) and causes early cardiovascular aging and progression of renal and cardiac disease. The aim of this longitudinal retrospective study was to evaluate the prevalence of HTN, the follow-up blood pressure trends, and risk factors for HTN in a population-based cohort with childhood-onset SLE (cSLE). Methods Demographic and clinical data of consecutive visits from the baseline to the last visit were extracted from electronic medical records of patients with cSLE. Results A total of 110 patients with cSLE were identified with a median follow-up duration of 29.5 months; 19% had lupus nephritis (LN) at diagnosis. Further, 29% and 23% had HTN and preHTN at the baseline visit. Compared to those without HTN, patients with HTN had higher disease activity, obesity, more frequent LN, and lower eGFR. In multivariate analysis, the presence of LN, obesity, and high extra-renal disease activity were independent predictors of HTN at baseline. Conclusions While HTN is a known feature of LN, HTN is common and persistent in cSLE without LN, with about one-third of patients having uncontrolled elevated blood pressure almost three years after the onset of lupus. In addition to LN, obesity and high overall disease activity were independent predictors of HTN.

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“…JSLE has an increased CVD and mortality risk compared to adult-onset SLE [ 12 , 125 , 126 ]. Investigating the development of atherosclerosis and CVD in these younger, more severely affected patients, has potential clinical value in identifying early mechanisms of vascular damage and biomarkers to guide management strategies [ 114 ]. Whilst traditional risk factors such as hypertension, diabetes and high cholesterol contribute to the increased cardiovascular risk (CVR) in SLE overall, they fail to fully account for it [ 127 ].…”

Section: Renal Biomarkersmentioning

confidence: 99%

“…Whilst traditional risk factors such as hypertension, diabetes and high cholesterol contribute to the increased cardiovascular risk (CVR) in SLE overall, they fail to fully account for it [ 127 ]. Ideally, all patients with SLE should receive monitoring and treatment for modifiable CVR factors [ 114 , 126 ]. The interplay between traditional CVR factors, increased disease associated inflammation and treatment burden in these younger patients could contribute to early, accelerated atherosclerosis in JSLE [ 125 , 127 , 128 ].…”

Section: Renal Biomarkersmentioning

confidence: 99%

Biomarkers Associated with Organ-Specific Involvement in Juvenile Systemic Lupus Erythematosus

Greenan-Barrett

Doolan

Shah

et al. 2021

IJMS

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Juvenile systemic lupus erythematosus (JSLE) is characterised by onset before 18 years of age and more severe disease phenotype, increased morbidity and mortality compared to adult-onset SLE. Management strategies in JSLE rely heavily on evidence derived from adult-onset SLE studies; therefore, identifying biomarkers associated with the disease pathogenesis and reflecting particularities of JSLE clinical phenotype holds promise for better patient management and improved outcomes. This narrative review summarises the evidence related to various traditional and novel biomarkers that have shown a promising role in identifying and predicting specific organ involvement in JSLE and appraises the evidence regarding their clinical utility, focusing in particular on renal biomarkers, while also emphasising the research into cardiovascular, haematological, neurological, skin and joint disease-related JSLE biomarkers, as well as genetic biomarkers with potential clinical applications.

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The vascular phenotype of children with systemic lupus erythematosus

Abstract: This study shows that our patients with JSLE had increased cIMT without an increase in PWV, suggesting possible early adaptive changes in JSLE. Follow-up data are needed to determine whether these changes result in clinically significant CVD.

Cited by 13 publications

References 49 publications

Increased Pulse Wave Velocity in Systemic Lupus Erythematosus: A Meta-Analysis

Increased Pulse Wave Velocity in Systemic Lupus Erythematosus: A Meta-Analysis

Blood pressure control over time in childhood-onset systemic lupus erythematous

Biomarkers Associated with Organ-Specific Involvement in Juvenile Systemic Lupus Erythematosus

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