The vascular pattern of the intestinal villi in various laboratory animals and man

Jacobson, Lyle F.; Noer, Rudolf J.

doi:10.1002/ar.1091140107

Cited by 52 publications

(14 citation statements)

References 2 publications

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“…The submucosal vessels were larger than 30 u diameter except for the small branches to the mucosa. No arterio-venous anastomoses were seen (confirming Jacobson & Noer, 1952) and this is confirmed by the small proportion of radioactivity in the liver. If any of these vessels (larger than 30 ,u) were arterio-venous anastomoses, microspheres would be expected to pass through them.…”

Section: Histological Studiessupporting

confidence: 57%

Effects of vasopressin and isoprenaline infusions on the distribution of blood flow in the intestine; criteria for the validity of microsphere studies

Greenway

Murthy

1972

British J Pharmacology

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Summary1. The distribution of superior mesenteric arterial flow was investigated by radioactive microspheres. The small intestine received 83% of the flow ((85 ml/min)/100 g intestine) and flow was uniform along the length of the small intestine. 2. The intestinal wall was separated into 3 layers-muscle, submucosa and mucosa. The muscle received (8 ml/min)/100 g intestine and the combined submucosa and mucosa (77 ml/min)/100 g intestine.3. The distribution of microspheres between the mucosa and submucosa depended on the size of the microspheres; the smaller the spheres, the more were found in the mucosa. It also depended on the state of the vascular bed; if microspheres were given during an infusion of vasopressin, a subsequent infusion of isoprenaline resulted in movement of some of the spheres from the submucosa into the mucosa. 4. Histological studies after India ink injection showed few capillary-sized vessels but many large vessels in the submucosa. Capillary-sized vessels arose close to the junction with the mucosa and passed into the mucosa. 5. These and other data suggest that the intestine consists of two parallelcoupled sections, one to the muscle and the other through the submucosa to the mucosa. The vessels in the submucosa are in series with those in the mucosa and submucosal shunts do not exist. Redistributions of flow between mucosa and submucosa cannot therefore occur during stimulation of the sympathetic nerves or infusions of drugs such as noradrenaline or adrenaline. 6. When microspheres are used in pharmacological investigations on distribution of blood flow in organs, controls to validate the method for the particular areas being studied are essential. If the vessels in the areas studied are in series rather than in parallel, the method is invalid.

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Section: Histological Studiessupporting

confidence: 57%

Effects of vasopressin and isoprenaline infusions on the distribution of blood flow in the intestine; criteria for the validity of microsphere studies

Greenway

Murthy

1972

British J Pharmacology

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“…JACOBSON and NOER, 1952;TRABUCCO and MARQUEZ, 1952;HALL, 1955;ELIAS, 1957;TAKAHATA et al, 1957TAKAHATA et al, , 1958HASE and BRIM, 1966;MOHIUDDIN, 1966;REYNOLDS et al, 1967;SAUNDERS, 1969;OKA, 1970;etc. ), scanning electron microscopy is advantageous because of the incomparably larger depth of focus and higher resolution (cf.…”

Section: Resin Injection and Corrosion Castingmentioning

confidence: 99%

Application of the Scanning Electron Microscope to the Study of the Fine Distribution of the Blood Vessels

Murakami

1971

Arch. Histol. Jap., Arch. Histol. Jpn

426

215

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“…Vascular architecture in the intestinal mucosa has been studied by many authors in man (SPANNER, 1932;JACOBSON and NOER, 1952), monkey (REYNOLDS et al, 1967), dog (REYNOLDS et al, 1972), rat (SPANNER, 1932;MOHIUDDIN, 1966), pig (BELLAMY et al, 1973) and other animals. However, owing to the limited or unpersuasive demonstration by the previous light microscope methods using injected sections (JACOBSON and NOER, 1952;NYLANDER and OLERUD, 1961;BELLAMY et al, 1973), falgog specimens (MOHIUDDIN, 1966) or insufficiently casted samples (REYNOLDS et al, 1967(REYNOLDS et al, , 1972, its details, especially the villous microcirculation, are conflicting.…”

Section: Discussionmentioning

confidence: 99%

“…However, owing to the limited or unpersuasive demonstration by the previous light microscope methods using injected sections (JACOBSON and NOER, 1952;NYLANDER and OLERUD, 1961;BELLAMY et al, 1973), falgog specimens (MOHIUDDIN, 1966) or insufficiently casted samples (REYNOLDS et al, 1967(REYNOLDS et al, , 1972, its details, especially the villous microcirculation, are conflicting. As noted by JACOBSON and NOER (1952), the previous descriptions can be classified into three categories.…”

Section: Discussionmentioning

confidence: 99%

“…(1) The afferent and efferent vein extend from the base to the tip of the villus and form a ladder-like capillary plexus between them (step-ladder concept, HENLE) (JACOBSON and NOER, 1952). (2) The afferent artery, after reaching the tip of the villus, gives rise to the capillaries which are collected at the base of the villus into the efferent vein (fountain pattern, MALL) (MOHIUDDIN, 1966;BELLAMY et al, 1973).…”

Section: Discussionmentioning

confidence: 99%

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Microcirculation of the Rat Small Intestine as Studied by the Injection Replica Scanning Electron Microscope Method

Ohashi

Kita

Murakami

1976

Arch. Histol. Jap., Arch. Histol. Jpn

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The vascular pattern of the intestinal villi in various laboratory animals and man

Cited by 52 publications

References 2 publications

Effects of vasopressin and isoprenaline infusions on the distribution of blood flow in the intestine; criteria for the validity of microsphere studies

Effects of vasopressin and isoprenaline infusions on the distribution of blood flow in the intestine; criteria for the validity of microsphere studies

Application of the Scanning Electron Microscope to the Study of the Fine Distribution of the Blood Vessels

Microcirculation of the Rat Small Intestine as Studied by the Injection Replica Scanning Electron Microscope Method

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