The vascular pathogenesis of gastroschisis: Intrauterine interruption of the omphalomesenteric artery

Limb–body wall defect. Is there a defensible hypothesis and can it explain all the associated anomalies?

“…Several of the experimental studies demonstrated that the initiating event in development of the limb and other malformations was an area of hemorrhage [Poswillo and Sopher, 1971;Poswillo, 1975;Kennedy and Persaud, 1977]. There followed a series of articles in the 1980s attributing a variety of birth defects, in addition to limb defects, to a presumptive vascular cause [Hoyme et al, 1981;Van Allen et al, 1982;Stevenson et al, 1986;Bavinck and Weaver, 1986].…”

Recreational Drug Use: A Major Risk Factor for Gastroschisis?

“…More recent theories have focused on a vascular pathogenesis for gastroschisis. These suggest that gastroschisis is either due to a vascular accident which causes occlusion of the right omphalomesenteric artery, resulting in necrosis at the base of the umbilical cord, creating an opening through which the intestines can eviscerate (Hoyme et al 1981); or to the premature atrophy or abnormal persistence of the right umbilical vein leading to mesenchymal damage and failure of the epidermis to differentiate at that site (deVries, 1980) The timing of the formation of gastroschisis is also the subject of some debate.…”

Defectos congénitos en un hospital de tercer nivel en Cali, Colombia

“…Se ha sugerido que puedan presentarse por agregaciones temporales o espaciales (29)(30)(31). Se han considerado como DDV a los defectos transversos de las extremidades, atresias intestinales, gastrosquisis, hidranencefalia, porencefalia, secuencia de hipogénesis oromandibular y de las extremidades, espectro oculoauriculovertebral, agenesia renal, aplasia cutis y síndrome de Moebius (32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45).…”