The Vascular Endothelium and Human Diseases

Rajendran, Peramaiyan; Rengarajan, Thamaraiselvan; Jayakumar, Thanasekaran; Nishigaki, Yutaka; Sakthisekaran, Dhanapal; Sethi, Gautam; Nishigaki, Ikuo

doi:10.7150/ijbs.7502

Cited by 1,194 publications

(998 citation statements)

References 118 publications

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“…44 Indeed, the endothelium is important for cardiovascular health, as it provides a protective layer, regulates vascular tone, and blood vessel growth. 44,45 When activated by inflammation or other stimuli, endothelial cells may become dysfunctional and can alter the underlying SMCs by releasing inflammatory cytokines. 45 Interestingly, a recent article by Mumby et al 46 established the implication of BRD4 in triggering the expression of inflammatory genes (IL-6 and IL-8) in human pulmonary microvascular endothelial cells.…”

Section: Discussionmentioning

confidence: 99%

“…44,45 When activated by inflammation or other stimuli, endothelial cells may become dysfunctional and can alter the underlying SMCs by releasing inflammatory cytokines. 45 Interestingly, a recent article by Mumby et al 46 established the implication of BRD4 in triggering the expression of inflammatory genes (IL-6 and IL-8) in human pulmonary microvascular endothelial cells. Also, a recent study suggested that BRD4 plays a role in the atherogenic processes by regulating an inflammatory response in endothelial cells.…”

Section: Discussionmentioning

confidence: 99%

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Implication of Inflammation and Epigenetic Readers in Coronary Artery Remodeling in Patients With Pulmonary Arterial Hypertension

Meloche

Lampron

Nadeau

et al. 2017

ATVB

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P ulmonary arterial hypertension (PAH) is a vascularremodeling disease (VRD) first described as an obstructive pathology affecting the distal pulmonary arteries. It is characterized by enhanced inflammation, vasoconstriction, and proliferation/apoptosis imbalance within the arterial wall, leading to increased pulmonary vascular resistance and right ventricular (RV) failure and death. 1 The smooth muscle cells (SMCs) within the pulmonary arterial wall exhibit exaggerated proliferation and resistance to apoptosis. Many groups have studied the underlying mechanisms of this "cancer-like" phenotype to find better ways to treat this deadly disease. The similarities in histological features between PAH and other VRDs suggest common pathogenic mechanisms. We and others have described the implication of the receptor of advanced glycation endproducts, 2-4 the oncoprotein kinase Pim-1 3, 5 and the transcription factor nuclear factor of activated T cells 6,7 in promoting proliferation in remodeling processes occurring in both VRD and PAH. In PAH patients' lung vasculature, these molecular actors are, at least in part, regulated by proinflammatory cytokines, alterations in the miR-223/DNA damage/ Poly[ADP-ribose] polymerase 1/miR-204 axis 8-11 and subsequent overexpression of the epigenetic reader bromodomain protein 4 (BRD4). 12 BRD4 functions as a scaffold for transcription factors at promoters and superenhancers, modulating the chromatin landscape and facilitating transcriptional activation of target genes. 13 Interestingly, BRD4 is also implicated in systemic VRD by triggering proinflammatory endothelial © 2017 American Heart Association, Inc. Objective-Pulmonary arterial hypertension (PAH) is a vascular disease not restricted to the lungs. Many signaling pathways described in PAH are also of importance in other vascular remodeling diseases, such as coronary artery disease (CAD). Intriguingly, CAD is 4× more prevalent in PAH compared with the global population, suggesting a link between these 2 diseases. Both PAH and CAD are associated with sustained inflammation and smooth muscle cell proliferation/ apoptosis imbalance and we demonstrated in PAH that this phenotype is, in part, because of the miR-223/DNA damage/ Poly[ADP-ribose] polymerase 1/miR-204 axis activation and subsequent bromodomain protein 4 (BRD4) overexpression. Interestingly, BRD4 is also a trigger for calcification and remodeling processes, both of which are important in CAD. Thus, we hypothesize that BRD4 activation in PAH influences the development of CAD. Approach and Results-PAH was associated with significant remodeling of the coronary arteries in both human and experimental models of the disease. As observed in PAH distal pulmonary arteries, coronary arteries of patients with PAH also exhibited increased DNA damage, inflammation, and BRD4 overexpression. In vitro, using human coronary artery smooth muscle cells from PAH, CAD and non-PAH-non-CAD patients, we showed that both PAH and CAD smooth muscle cells exhibited increased proliferation and suppres...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Implication of Inflammation and Epigenetic Readers in Coronary Artery Remodeling in Patients With Pulmonary Arterial Hypertension

Meloche

Lampron

Nadeau

et al. 2017

ATVB

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show abstract

“…It is well known that the endothelium is directly involved in vascular disease, stroke, heart disease, and diabetes [5]. Especially, diabetes has been reported to increase the risk of cardiovascular disease by accelerating the formation of atherosclerosis [6].…”

Section: Introductionmentioning

confidence: 99%

Cyclic phosphatidic acid inhibits the secretion of vascular endothelial growth factor from diabetic human coronary artery endothelial cells through peroxisome proliferator-activated receptor gamma

Tsukahara

Haniu

et al. 2015

Molecular and Cellular Endocrinology

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“…Johnson et al (2014) with a single session, also observed a significant increase in the skin blood flow. These findings are of clinical importance due to endothelial dysfunction with capillary alterations and impairment of the blood flow in this population group (Rajendran et al, 2013;Coelho et al, 2011;Widmer and Lerman 2014;Murray et al, 2004). After 12-week WBV training changes on leg blood flow were accompanied by positive changes in body composition (Sañudo et al, 2013).…”

Section: Effects On Clinical Populationsmentioning

confidence: 92%

Potential Effects of Whole-Body Vibration Exercises on Blood Flow Kinetics of Different Populations: A Systematic Review With a Suitable Approach

Sá-Caputo¹,

Paineiras-Domingos²,

Carvalho-Lima³

et al. 2017

Afr J Tradit Complement Altern Med

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Background:The ability to control skin blood flow decreases with advancing age and some clinical disorders, as in diabetes and in rheumatologic diseases. Feasible clinical strategies such as whole-body vibration exercise (WBVE) are being used without a clear understanding of its effects. The aim of the present study is to review the effects of the WBVE on blood flow kinetics and its feasibility in different populations.Material and Methods:The level of evidence (LE) of selected papers in PubMed and/or PEDRo databases was determined. We selected randomized, controlled trials in English to be evaluated.Results:Six studies had LE II, one had LE III-2 and one III-3 according to the NHMRC. A great variability among the protocols was observed but also in the assessment devices; therefore, more research about this topic is warranted.Conclusion:Despite the limitations, it is can be concluded that the use of WBVE has proven to be a safe and useful strategy to improve blood flow. However, more studies with greater methodological quality are needed to clearly define the more suitable protocols.

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The Vascular Endothelium and Human Diseases

Cited by 1,194 publications

References 118 publications

Implication of Inflammation and Epigenetic Readers in Coronary Artery Remodeling in Patients With Pulmonary Arterial Hypertension

Implication of Inflammation and Epigenetic Readers in Coronary Artery Remodeling in Patients With Pulmonary Arterial Hypertension

Cyclic phosphatidic acid inhibits the secretion of vascular endothelial growth factor from diabetic human coronary artery endothelial cells through peroxisome proliferator-activated receptor gamma

Potential Effects of Whole-Body Vibration Exercises on Blood Flow Kinetics of Different Populations: A Systematic Review With a Suitable Approach

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