The Vascular Depression Subtype: Evidence of Internal Validity

Sneed, Joel R.; Rindskopf, David; Steffens, David C.; Krishnan, K. Ranga Rama; Roose, Steven P.

doi:10.1016/j.biopsych.2008.03.032

Cited by 104 publications

(94 citation statements)

References 43 publications

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“…All patients who underwent MRI were screened for the inclusion and exclusion criteria. The inclusion criteria for the study were: (1) Chinese ethnicity; (2) Cantonese as the primary language; (3) age 18 years or older; (4) well-documented (clinical presentation and CT scan of the brain) first or recurrent acute lacunar stroke occurring within 7 days before admission (a lacunar stroke was defined as at least 1 symptomatic infarction [diameter [2][3][4][5][6][7][8][9][10][11][12][13][14][15] …”

Section: Subjectsmentioning

confidence: 99%

“…8 White matter hyperintensities are conceptualized as a sign of vascular damage to brain structures and they contribute to the development of vascular depression. 9 CMB are also indicators of underlying vascular damage; hence, it is surprising that no previous study has examined the relationship between CMB and depression in stroke or other patient populations.…”

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confidence: 99%

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Cerebral Microbleeds and Depression in Lacunar Stroke

Tang

Chen

et al. 2011

Stroke

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Background and Purpose-Cerebral microbleeds (CMB) are common in stroke survivors and the community-dwelling elderly. The clinical significance of CMB in the development of depression after a stroke is unknown. This study examined the association between poststroke depression (PSD) and CMB. Methods-A cohort of 235 patients with acute lacunar stroke admitted to the stroke unit of a university-affiliated regional hospital in Hong Kong was recruited. Three months after the onset of the index stroke, a research assistant administered the locally validated 15-item Geriatric Depression Scale. PSD was defined as a Genetic Depression Scale score of Ն7.The presence and location of CMB were evaluated with MRI. Results-In comparison with the non-PSD group, PSD patients were more likely to have lobar CMB (33.3% versus 19.9%; Pϭ0.022). Lobar CMB remained an independent predictor of PSD in the multivariate analysis, with an odds ratio of 2.08 (Pϭ0.032). Conclusions-The

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Section: Subjectsmentioning

confidence: 99%

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confidence: 99%

Cerebral Microbleeds and Depression in Lacunar Stroke

Tang

Chen

et al. 2011

Stroke

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“…The total CAMCOG Executive Function score was the sum of the individual test and higher scores were indicative of better executive function. Executive dysfunction was defined as the score on the CAMCOG Executive Function located in the lowest quartile (Sneed et al, 2008).…”

Section: Depression Diagnosesmentioning

confidence: 99%

Depression subtypes and 5‐years risk of mortality in aged 70 years: a population‐based cohort study

Vilalta-Franch

Planas-Pujol

López-Pousa

et al. 2011

Int J Geriat Psychiatry

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“…Indeed, cross-sectional and longitudinal studies have supported that VaD has content, predictive, and discriminant validity, although the neuroimaging finding "white matter hyperintensity" was more accurate in predicting VaD than other "classic" cerebrovascular risk factors (CRFs), such as age, diabetes mellitus, arterial hypertension, smoking, and so on. [9][10][11] Moreover, assuming its validity, it is difficult to explain certain observations such as the soaring incidence of CRFs in the elderly, which is not accompanied by a corresponding increase in depression; or the absence of significant association between depression and other robust CRFs such as hypercholesterolemia and smoking. 12 Therefore, some authors suggested that VaD is better described as "subcortical ischemic depression" 13 rather than as a "vascular depression".…”

Section: Introductionmentioning

confidence: 99%

Therapeutic interventions for vascular depression: a systematic review

Brunoni

Benseñor

Alves

2011

Rev. Bras. Psiquiatr.

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Objective: Vascular depression (VaD) hypothesis supports a bidirectional relationship between cerebrovascular risk factors (CRFs) and depression. We examined whether such concept is appropriate for clinical interventions; i.e., whether treating depressive symptoms has an impact on cerebrovascular risk and vice-versa. Method: Systematic review on interventional studies published from October-1997 to April-2010 on MEDLINE and other databases. Search terms were "depressive disorder" (MeSH), "cerebrovascular disorders" (MeSH), and a batch of highly accurate terms to search for experimental and quasi-experimental trials. We used a structured questionnaire to assess the adequacy of the VaD criteria used for vascular, depression, neuroimaging, and neuropsychological features, as well as the main results of each study. Results: Of the 357 retrieved studies, 12 met our eligibility criteria. These studies adequately reported depression criterion, moderately reported neuroimaging and neuropsychological criteria, and showed severe flaws in vascular assessment. Efficacy trials suggested that nimodipine, transcranial magnetic stimulation, carotid stent placement, and citalopram were effective for VaD. Exploratory studies suggested that white-matter hyperintensities and global vascular risk are predictors of poor response. Although the low quality of the studies hinders the findings' generalization, studies of higher validity support the VaD concept for interventions. Conclusion: VaD seems to be a useful concept for clinical interventions; however, further trials should refine CRFs criteria to assess its impact on antidepressant efficacy. ©2011 Elsevier Editora Ltda. All rights reserved. DesCRIpToRs:Major depressive disorder; Cerebrovascular disorders; Depression; Review; Therapeutics. ReVIeW ARTICLe Therapeutic interventions for vascular depression: a systematic review Intervenções terapêuticas para a depressão vascular: uma revisão sistemática ResumoObjetivo: A hipótese da depressão vascular (DV) defende uma correlação bidirecional entre fatores de risco cerebrovasculares e depressão. Nós investigamos se este conceito é apropriado para intervenções clínicas -ou seja, se o tratamento de sintomas depressivos modifica o risco cerebrovascular e vice-versa. Método: Revisão sistemática de estudos intervencionistas publicados entre outubro/1997 e abril/2010 nos bancos de dados MEDLINE e outros. Os unitermos procurados foram "depressive disorder" (MeSH), "cerebrovascular disorders" (MeSH) e um conjunto de termos altamente acurados para procurar por estudos experimentais ou quasi-experimentais. Nós usamos um questionário estruturado para examinar se os critérios de DV usados para depressão, vascular, neuroimagem e neuropsicológicos foram adequados, e os resultados principais de cada estudo. Resultados: De 357 artigos obtidos, 12 foram inclusos. Eles relataram adequadamente o critério de depressão, moderadamente os critérios neuropsicológicos e de neuroimagem e apresentaram erros graves no critério vascular. Estudos de eficác...

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The Vascular Depression Subtype: Evidence of Internal Validity

Abstract: These findings, replicated across two independent clinical samples, provide the first support for the internal validity of vascular depression as a subtype of late-life depression.

Cited by 104 publications

References 43 publications

Cerebral Microbleeds and Depression in Lacunar Stroke

Cerebral Microbleeds and Depression in Lacunar Stroke

Depression subtypes and 5‐years risk of mortality in aged 70 years: a population‐based cohort study

Therapeutic interventions for vascular depression: a systematic review

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