The vascular contribution of apolipoprotein E to Alzheimer’s disease
Feng Chen,
Jing Zhao,
Fanxia Meng
et al.
Abstract:Alzheimer’s disease, the most prevalent form of dementia, imposes a substantial societal burden. The persistent inadequacy of disease-modifying drugs targeting amyloid plaques and neurofibrillary tangles suggests the contribution of alternative pathogenic mechanisms. A frequently overlooked aspect is cerebrovascular dysfunction, which may manifest early in the progression of Alzheimer’s disease pathology. Mounting evidence underscores the pivotal role of the apolipoprotein E gene, particularly the apolipoprote… Show more
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