1981
DOI: 10.1084/jem.154.5.1319
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The vascular bed as the primary target in the destruction of skin grafts by antiserum. I. Resistance of freshly placed xenografts of skin to antiserum

Abstract: We have shown that both xenografts and allografts of rat skin can be acutely and severely damaged by antisera specifically reactive with graft antigens, and that in appropriate circumstances the phenomenon can be elicited routinely (1, 2). A matter of paramount importance among the variables that influence the occurrence of this form of immunologically mediated tissue damage is the interval of time between the placement of the grafts and the administration of antiserum (3). Contrary to widely held views on the… Show more

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Cited by 31 publications
(16 citation statements)
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References 8 publications
(4 reference statements)
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“…During rejection of Mig-deficient skin allografts, the chemokine protein was clearly present in the vascular endothelium of the lower dermis and was associated with cells around the vessels. These results are consistent with the neovascularization of the skin allograft by recipient endothelium [23][24][25] and the importance of this source of Mig in directing T-cell infiltration into the allograft. In contrast, Mig protein was not detected in vascular structures in the upper dermal vascular plexus of Mig Ϫ/Ϫ allografts and there was little to no detectable T-cell infiltration into this area of the allograft until late in the delayed rejection of the grafts.…”
Section: Discussionsupporting
confidence: 78%
“…During rejection of Mig-deficient skin allografts, the chemokine protein was clearly present in the vascular endothelium of the lower dermis and was associated with cells around the vessels. These results are consistent with the neovascularization of the skin allograft by recipient endothelium [23][24][25] and the importance of this source of Mig in directing T-cell infiltration into the allograft. In contrast, Mig protein was not detected in vascular structures in the upper dermal vascular plexus of Mig Ϫ/Ϫ allografts and there was little to no detectable T-cell infiltration into this area of the allograft until late in the delayed rejection of the grafts.…”
Section: Discussionsupporting
confidence: 78%
“…Neovascularized porcine neural tissue survives longer in immunoglobulin‐deficient mice than WT mice [46], supporting a role for antibodies in rejection. A role for xenoantibodies in rat skin xenograft rejection has also been demonstrated [47,48].…”
Section: Discussionmentioning
confidence: 99%
“…They found a notable time dependence of susceptibility to antibody mediated rejection. Grafts were resistant to mouse anti-rat serum during the first 7–10 days after transplantation, but gradually became susceptible to immune serum and reached a peak of sensitivity at 14–16 days after grafting [21,22]. If the graft survived beyond that time, the graft once again became resistant to antiserum for as long as they survived [21].…”
Section: Acute Amr: Experimental Studiesmentioning
confidence: 99%