The Varying Place of the Dead in Pylos

Murphy, Joanne M. A.

doi:10.2307/j.ctt1287gx6.24

Cited by 11 publications

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“…19 To this end, a diverse series of reductants spanning a range of reduction potentials was evaluated in the carboxylation of 4-chloroanisole with (PPh 3 ) 2 Ni II Cl 2 as the precatalyst to explore the effect of reductant speciation and potential on catalyst performance (Table 2). Specifically, we tested the one electron organometallic, homogeneous reductants decamethylcobaltocene (Cp* 2 Co) 20 and cobaltocene (Cp 2 Co), 21 as well as the organic, homogeneous two-electron reductants tetrakis(dimethylamino)ethylene (TDAE) 22 and DMAP-OED, 23 which is an organic electron donor derived from 4-(dimethylamino)pyridine that was first reported by Murphy and co-workers. These reductants were compared to the standard metallic, heterogeneous two electron reductants Mn 0 and Zn 0 in catalysis.…”

Section: Empirical Investigation Into the Role Of Different Reagents mentioning

confidence: 99%

“…This is the first example of an organic reductant being utilized in a reductive carboxylation reaction without concomitant photoredox catalysis. 8n,9d Additionally, DMAP-OED can be prepared in two steps from relatively inexpensive starting materials (each less than $100/kg) and is a solid at room temperaure, 23 which makes it easier to work with than volatile liquid organic reductants such as TDAE. 19,26 From a mechanistic perspective, no catalysis was observed with DMAP-OED as the reductant in the absence of MnCl 2 .…”

Section: Empirical Investigation Into the Role Of Different Reagents mentioning

confidence: 99%

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Development of an Improved System for the Carboxylation of Aryl Halides through Mechanistic Studies

et al. 2019

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The nickel-catalyzed carboxylation of organic halides or pseudohalides using carbon dioxide is an emerging method to prepare synthetically valuable carboxylic acids. Here, we report a detailed mechanistic investigation of these reactions using the carboxylation of aryl halides with (PPh 3) 2 Ni II Cl 2 as a model reaction. Our studies allow us to understand several general features of nickel-catalyzed carboxylation reactions. For example, we demonstrate that both a Lewis acid and halide source are beneficial for catalysis. To this end, we establish that heterogeneous Mn(0) and Zn(0) reductants are multifaceted reagents that generate noninnocent Mn(II) or Zn(II) Lewis acids upon oxidation. In a key result, a rare example of a well-defined nickel(I) aryl complex is isolated, and it is demonstrated that its reaction with carbon dioxide results in the formation of a carboxylic acid in high yield (after workup). The carbon dioxide insertion product undergoes rapid decomposition, which ca These three oxidation states correspond to the onbe circumvented by a ligand metathesis reaction with a halide source. Our studies have led to both a revised mechanism and the development of a broadly applicable strategy to improve reductive carboxylation reactions. A critical component of this strategy is that we have replaced the heterogeneous Mn(0) reductant typically used in catalysis with a well-defined homogeneous organic reductant. Through its use, we have increased the range of ancillary ligands, additives, and substrates that are compatible with the reaction. This has enabled us to perform reductive carboxylations at low catalyst loadings. Additionally, we demonstrate that reductive carboxylations of organic (pseudo)halides can be achieved in high yields in more practically useful, non-amide solvents. Our results describe a mechanistically guided strategy to improve reductive carboxylations through the use of a homogeneous organic reductant, which may be broadly translatable to a wide range of crosselectrophile coupling reactions.

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Section: Empirical Investigation Into the Role Of Different Reagents mentioning

confidence: 99%

Section: Empirical Investigation Into the Role Of Different Reagents mentioning

confidence: 99%

Development of an Improved System for the Carboxylation of Aryl Halides through Mechanistic Studies

et al. 2019

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“…Tragana 2*, Voidhokoilia, Psari*, Thorikos IV*, Corinth*) 48 . Only two examples with relatively long dromoi may be dated to the earlier part of LH I (Routsi 2 and Pylos IV), but ceramic evidence for this dating is not conclusive (Lolos 1987, 184–6, 209–10: Murphy 2014, 213; Davis and Stocker 2014); Pylos IV, in particular, has architectural refinements which seem incompatible with such an early construction date (Pelon 1976, 395–6, 401).…”

Section: Discussionmentioning

confidence: 99%

“… 9 E.g. the tholoi of Osmanaga (Blegen 1954; Lolos 1987, 177–8), Pylos ‘Vagenas’ (Blegen et al 1973, 148–53; Lolos 1987, 188–94), Pylos IV (Blegen et al 1973, 105, 107; Murphy 2014, 213), Galatas 3 (Konsolaki-Giannopoulou 2003, 178–80); the small tholos Tourkokivoura 4 (Lolos 1987, 157–9); several BCTs from Eleusis (Zπ6, Hπ1, Hπ5, Hπ20, Iπ1, Θπ4, Θπ6, Μπ3, Μπ4, Μπ9, Ε1, Ε.ΙΙΙ.7, Papadimitriou 2001a 68–78; Cosmopoulos 2014, 139–42) and Dramesi (Blegen 1949); and some of the Epidaurus Limera chamber tombs (Gallou 2009, 91). …”

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confidence: 99%

The Formation and Use of Dromoi in Early Mycenaean Tombs

Papadimitriou¹

2015

Annu. Br. Sch. Athens

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The paper examines how the dromos emerged as an architectural feature in Mycenaean tombs and why it became the standard type of access device. It focuses on collective tombs with lateral entrances of LH I and transitional LH I/IIA date in mainland Greece, but considers also a number of MH tombs with side entrances. The first part discusses the architectural evidence. The second part examines permanent installations and evidence of possible ritual activities from dromoi. The third part explores the symbolic and performative aspects of dromoi. It is argued that the dromos was not an integral part of Mycenaean funerary architecture from the very beginning, but came about gradually out of a long process of experimentation, which originated in MH tumuli and was completed in late LH I or LH I/IIA tholoi and chamber tombs. This process merged different building traditions and combined practical considerations with new ritual needs arising at a period of intense social and cultural change.

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“…All anhydrous solvents were obtained from Sigma-Aldrich, UK or Acros Organics, UK. 47 [23] (methyl 6-(bromomethyl)-2-naphthoate), 50 [24] (methyl 6-(chlorocarbonyl)-2naphthoate), 53 [25] (6-(hydroxymethyl)-2-naphthoic acid), 55 [26] (2-bromo-6-(bromomethyl)naphthalene), 61 [27] (7-bromo-3-hydroxy-2-naphthoic acid) and 70 [28,29] (6-(methoxymethoxy)naphthalen-2-yl trifluoromethane-sulfonate) were synthesized according to literature procedures.…”

Section: Chemistry Experimentalmentioning

confidence: 99%

Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid

Irvine

Fang

Sapkota

et al. 2019

European Journal of Medicinal Chemistry

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The N-methyl-D-aspartate receptor (NMDAR), a ligand-gated ion channel activated by Lglutamate and glycine, plays a major role in the synaptic plasticity underlying learning and memory. NMDARs are involved in neurodegenerative disorders such as Alzheimer's and Parkinson's disease and NMDAR hypofunction is implicated in schizophrenia. Herein we describe structure-activity relationship (SAR) studies on 2-naphthoic acid derivatives to investigate

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The Varying Place of the Dead in Pylos

Cited by 11 publications

References 0 publications

Development of an Improved System for the Carboxylation of Aryl Halides through Mechanistic Studies

Development of an Improved System for the Carboxylation of Aryl Halides through Mechanistic Studies

The Formation and Use of Dromoi in Early Mycenaean Tombs

Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid

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