The various routes to functional regeneration in the central nervous system

Echeverri, Karen

doi:10.1038/s42003-020-0773-z

Cited by 4 publications

(4 citation statements)

References 33 publications

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“…In other species capable of CNS regeneration, including zebrafish [ 20 ], Xenopus [ 24 ], and lamprey [ 25 ], a similar upregulation of Fos and Jun expression is shown after injury. However, both Xenopus and lampreys lack a GFAP gene, indicating that the formation of a Fos/Jun heterodimer may regulate alternative glial-specific genes in these species [ 26 ].…”

Section: Activation Of Neural Stem Cellsmentioning

confidence: 99%

Spinal cord regeneration — the origins of progenitor cells for functional rebuilding

Walker

Echeverri

2022

Current Opinion in Genetics & Development

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Section: Activation Of Neural Stem Cellsmentioning

confidence: 99%

Spinal cord regeneration — the origins of progenitor cells for functional rebuilding

Walker

Echeverri

2022

Current Opinion in Genetics & Development

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“…Furthermore, when MSCs are put on the microenvironment of injured cells, they can easily create different elements like TGF-β as well as IGF-1 that trigger the activation of astrocytes. Consequently, the triggered astrocytes can easily clear Aβ plaque deposition as well as which likewise might trick TGF-β 93 as well as IGF-1 94 as neuroprotective elements. Nevertheless, the activation of astrocytes has \both advantages and disadvantages.…”

Section: Msc Therapy For Ad: Astrocyte-mediated Neuroinflammationmentioning

confidence: 99%

Untitled

2022

IJPSR

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Mesenchymal Stem Cells are multipotent adult stem cells that are found in tissues of the body, including umbilical lines, bone marrow, fat cells, etc. Mesenchymal stem cells incline to self-restore tissues, such as bone, fat cells, connective tissues, and microglia cells, which are obtained from the mesoderm layer and act as macrophages in the central nervous system. So, MSCs can be used to promote functional recovery in many neurological disorders. Neuroinflammation is a pathological feature of neurodegenerative diseases, which is also indicated to mediate neuronal damage and deteriorate the backward accumulation of Aβ in Alzheimer's disease. The mechanism for MSC-based therapy in Alzheimer's disease that MSCs regulate neuroinflammation by microglia activation; this will reduce pathological features such as tau hyperphosphorylation and Aβ deposits and save the spatial learning and memory deficits and their multipotentiality and secretome, based on these findings include cell therapy methods for Parkinson disease mainly focused on the ability of stem cells to differentiate into Dopaminergic neurons producing cells that will replace diseased Dopaminergic neurons. MSC-based therapeutics have been suggested for osteoarthritis. MSCs were mostly found in a thin layer of connective tissue called periosteum, lungs, milk teeth, tendon, synovial stratum, cancellous bone, adipose tissue, tendon, lung, and other tissues. MSCs associated with immune cells and have immunomodulatory effects. Moreover, the RAP1/NFkb signalling pathway controls MSC paracrine activity, which seems to be linked with Female infertility. This review will assist you in understanding many aspects of MSC and its molecular role and therapeutic applications.

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“…Beyin ve omurilik gibi insanda rejenerasyon kapasitesi çok düşük olan dokuları kolayca yenileyebilmeleri nedeniyle de sinir bilim çalışmalarında popüler organizma haline gelmişlerdir (Lust & Tanaka, 2019;Demircan et al, 2020). Sinir doku rejenerasyon kapasitelerinin araştırıldığı çalışmalar, rejenerasyonda aktif rol alan hücresel yolaklar, hedef genler, kodlanmayan RNA'lar gibi moleküler belirteçlere odaklanmıştır (Sibai et al, 2019;Sabin et al, 2019;Diaz & Echeverri, 2013;Echeverri, 2020).…”

Section: Introductionunclassified

Mersin Üniversitesi Su Ürünleri Fakültesi Uygulama Birimleri’nde Rejeneratif Tıp Araştırmalarında Model Organizma Olarak Yetiştirilen Ambystoma mexicanum’un DNA Barkodlaması ve Filogenisi

ARSLAN¹,

Sönmez

Korkmaz³

et al. 2021

Commagene Journal of Biology

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Ambystoma mexicanum belongs to the family Ambystomatidae. It is one of the 30 species of the genus Ambystoma, which lives in a wide geography from southern Mexico to southern Alaska. It is accepted as a model organism in evolutionary biology, developmental biology, and regenerative medicine research. It can regenerate the brain, heart, and kidney organs as well as limb regeneration. Accurate identification of the model organism is important for the reproducibility and comparability of experiments. We aimed to confirm the species identification of axolotls using integrated taxonomic methods that were grown at Mersin University Aquaculture Units of the Faculty of Fisheries. Cytochrome oxidase subunit 1 (COI) and cytochrome b (Cytb) gene fragments of mtDNA sequences were used as molecular markers for phylogenetic analyses and species delimitation methods and compared with the sequences that were submitted to NCBI GenBank as species of Ambystoma. In the analyses that were conducted with different data sets, the individuals in question were grouped as a candidate species with the A. mexicanum species whose sequences were given in previous studies. All sequences obtained in this study and A. mexicanum sequences obtained from NCBI GenBank were grouped as haplotypes and their genetic distances were found to be 0 and it was determined that the individuals which were the subject of this study definitely belong to the A. mexicanum species. The results revealed that some species within the genus Ambystoma, especially A. barbouri and A. texanum, may be species complexes. On the other hand, A. mexicanum was grouped together with A. andersoni as candidate species in all analyses performed with the combined datasets of COI, Cytb, and COI+Cytb. These results revealed that the taxa in question are paraphyletic and should be assigned to the A. mexicanum species.

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The various routes to functional regeneration in the central nervous system

Cited by 4 publications

References 33 publications

Spinal cord regeneration — the origins of progenitor cells for functional rebuilding

Spinal cord regeneration — the origins of progenitor cells for functional rebuilding

Untitled

Mersin Üniversitesi Su Ürünleri Fakültesi Uygulama Birimleri’nde Rejeneratif Tıp Araştırmalarında Model Organizma Olarak Yetiştirilen Ambystoma mexicanum’un DNA Barkodlaması ve Filogenisi

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