The Variable Effects of NSAIDs on Osteotomy Healing and Opioid Consumption

Fragomen, Austin T.; Suh, Jaehee; Matta, Kelsey; McCoy, Thomas H.; Hart, Kamber L.; Rozbruch, S. Robert

doi:10.5435/jaaosglobal-d-20-00039

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…Even studies undertaken in patients undergoing operations where bone healing or fusion is a desired outcome of surgery do not show a detrimental effect of NSAIDs on this surgical outcome. After osteotomy of a long bone, there was no difference in the time to union between patients treated with an NSAID pain protocol or an NSAID-free pain protocol [ 24 ]. After spinal fusion, a systematic review could not identify any RCT and concluded from the studies of lower quality, that postoperative NSAID short-term use (for less than 2 weeks) does not increase the risk of non-union [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

Do NSAIDs Really Interfere with Healing after Surgery?

Schug

2021

JCM

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Perioperative analgesia should be multimodal to improve pain relief, reduce opioid use and thereby adverse effects impairing recovery. Non-steroidal anti-inflammatory drugs (NSAIDs) are an important non-opioid component of this approach. However, besides potential other adverse effects, there has been a longstanding discussion on the potentially harmful effects of NSAIDs on healing after surgery and trauma. This review describes current knowledge of the effects of NSAIDs on healing of bones, cartilage, soft tissue, wounds, flaps and enteral anastomoses. Overall, animal data suggest some potentially harmful effects, but are contradictory in most areas studied. Human data are limited and of poor quality; in particular, there are only very few good randomized controlled trials (RCTs), but many cohort studies with potential for significant confounding factors influencing the results. The limited human data available are not precluding the use of NSAIDs postoperatively, in particular, short-term for less than 2 weeks. However, well-designed and large RCTs are required to permit definitive answers.

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Section: Resultsmentioning

confidence: 99%

Do NSAIDs Really Interfere with Healing after Surgery?

Schug

2021

JCM

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“…A retrospective cohort study by Fragomen et al reviewed 155 limbs that underwent osteotomy and internal fixation with a pain regimen that either included nonsteroidal anti-inflammatory drugs (NSAIDs) or did not 62 . The group that received NSAIDs had no difference in time to union but had fewer milligram equivalents of morphine prescribed.…”

Section: Therapeuticsmentioning

confidence: 99%

What’s New in Limb Lengthening and Deformity Correction

Georgiadis

Morrison

Dahl

2021

Journal of Bone and Joint Surgery

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The purpose of this form is to provide readers of your manuscript with information about your other interests that could influence how they receive and understand your work. The form is designed to be completed electronically and stored electronically. It contains programming that allows appropriate data display. Each author should submit a separate form and is responsible for the accuracy and completeness of the submitted information. The form is in six parts. Identifying information. The work under consideration for publication.This section asks for information about the work that you have submitted for publication. The time frame for this reporting is that of the work itself, from the initial conception and planning to the present. The requested information is about resources that you received, either directly or indirectly (via your institution), to enable you to complete the work. Checking "No" means that you did the work without receiving any financial support from any third party --that is, the work was supported by funds from the same institution that pays your salary and that institution did not receive third-party funds with which to pay you. If you or your institution received funds from a third party to support the work, such as a government granting agency, charitable foundation or commercial sponsor, check "Yes". Relevant financial activities outside the submitted work.This section asks about your financial relationships with entities in the bio-medical arena that could be perceived to influence, or that give the appearance of potentially influencing, what you wrote in the submitted work. You should disclose interactions with ANY entity that could be considered broadly relevant to the work. For example, if your article is about testing an epidermal growth factor receptor (EGFR) antagonist in lung cancer, you should report all associations with entities pursuing diagnostic or therapeutic strategies in cancer in general, not just in the area of EGFR or lung cancer.Report all sources of revenue paid (or promised to be paid) directly to you or your institution on your behalf over the 36 months prior to submission of the work. This should include all monies from sources with relevance to the submitted work, not just monies from the entity that sponsored the research. Please note that your interactions with the work's sponsor that are outside the submitted work should also be listed here. If there is any question, it is usually better to disclose a relationship than not to do so.For grants you have received for work outside the submitted work, you should disclose support ONLY from entities that could be perceived to be affected financially by the published work, such as drug companies, or foundations supported by entities that could be perceived to have a financial stake in the outcome. Public funding sources, such as government agencies, charitable foundations or academic institutions, need not be disclosed. For example, if a government agency sponsored a study in which you have been involved and drugs w...

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“…NSAIDs can be used as an additive therapy or even an alternative analgesic treatment. Following major surgery, NSAIDs can negate the need for opioids (10) and shorten the required hospital stay (11). Nonetheless, NSAIDs are likely to cause impaired fracture consolidation and are avoided after bone surgery, despite their benefits (12,13).…”

Section: Introductionmentioning

confidence: 99%

The Influence of Ibuprofen on the Healing of Colles’ Fracture

Aliuskevicius

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The Variable Effects of NSAIDs on Osteotomy Healing and Opioid Consumption

Cited by 4 publications

References 16 publications

Do NSAIDs Really Interfere with Healing after Surgery?

Do NSAIDs Really Interfere with Healing after Surgery?

What’s New in Limb Lengthening and Deformity Correction

The Influence of Ibuprofen on the Healing of Colles’ Fracture

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