The Variable Characteristics of Human Papillomavirus in Squamous Cell Carcinoma and Adenocarcinoma of Cervix in China

Chen, Wen; Sun, Haikui; Molijn, Anco; Zeng, Liang; Kang, Lakhwinder Singh; Jenkins, David; Zhang, Shaokai; Cui, Jianfeng; Wu, Zeni; Pirog, Edyta C.; Shen, Guihua; Zhang, Xun; Qiao, You‐Lin

doi:10.1097/lgt.0000000000000408

Cited by 19 publications

(20 citation statements)

References 33 publications

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“…The most common HPV types distributed in cervical adenocarcinoma were HPV16 and HPV18 39 . Expression of HPV oncogenes E6 and E7 is a key event in the malignant transformation of HPV-infected cervical cells 40 .…”

Section: Resultsmentioning

confidence: 99%

Transcriptome analysis uncovers the diagnostic value of miR-192-5p/HNF1A-AS1/VIL1 panel in cervical adenocarcinoma

Zou

et al. 2020

Sci Rep

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Despite the fact that the incidence of cervical squamous cell carcinoma has decreased, there is an increase in the incidence of cervical adenocarcinoma. However, our knowledge on cervical adenocarcinoma is largely unclear. Transcriptome sequencing was conducted to compare 4 cervical adenocarcinoma tissue samples with 4 normal cervical tissue samples. mRNA, lncRNA, and miRNA signatures were identified to discriminate cervical adenocarcinoma from normal cervix. The expression of VIL1, HNF1A-AS1, MIR194-2HG, SSTR5-AS1, miR-192-5p, and miR-194-5p in adenocarcinoma were statistically significantly higher than that in normal control samples. The Receiver Operating Characteristic (ROC) curve analysis indicated that combination of miR-192-5p, HNF1A-AS1, and VIL1 yielded a better performance (AUC = 0.911) than any single molecule -and could serve as potential biomarkers for cervical adenocarcinoma. Of note, the combination model also gave better performance than TCT test for cervical adenocarcinoma diagnosis. However, there was no correlation between miR-192-5p or HNF1A-AS1 and HPV16/18 E6 or E7. VIL1 was weakly correlated with HPV18 E7 expression. In summary, our study has identified miR-192-5p/HNF1A-AS1/VIL1 panel that accurately discriminates adenocarcinoma from normal cervix. Detection of this panel may provide considerable clinical value in the diagnosis of cervical adenocarcinoma.

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Section: Resultsmentioning

confidence: 99%

Transcriptome analysis uncovers the diagnostic value of miR-192-5p/HNF1A-AS1/VIL1 panel in cervical adenocarcinoma

Zou

et al. 2020

Sci Rep

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“…Chen found that HPV 18 accounted for a larger proportion in ADC. 37 Mabuchi found that HPV 18 can be used as a prognostic factor to evaluate the prognosis of ADC. 38 However, in our study, we mainly focused on the predictive effect of preoperative serum tumor markers on early ADC prognosis.…”

Section: Discussionmentioning

confidence: 99%

<p>Combined Evaluation of Preoperative Serum CEA and CA125 as an Independent Prognostic Biomarker in Patients with Early-Stage Cervical Adenocarcinoma</p>

Huang

Chen

et al. 2020

OTT

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There is currently a lack of research on preoperative prognostic analysis of earlystage cervical adenocarcinoma (ADC). The purpose of our study was to clarify whether preoperative serum tumor-marker levels were of prognostic value in early-stage ADC. Patients and Methods: We performed a retrospective study of patients with International Federation of Gynecology and Obstetrics (FIGO) stage IA1-IIA1 and pathology-proven invasive ADC. We evaluated the relationship between preoperative serum tumor-marker levels and clinicopathological characteristics, and identified the relative preoperative risk factors affecting disease-free survival (DFS) and overall survival (OS). The optimal cutoff point of meaningful tumor markers was determined by the analysis of receiver operating characteristics (ROC), and the accuracy of the results was evaluated by the area under the curve (AUC). Results: Elevated carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), squamous cell carcinoma antigen (SCC-Ag), alpha-fetoprotein (AFP), carbohydrate antigen 153 (CA153) and carbohydrate antigen 199 (CA199) were associated with certain clinicopathologic features of early-stage ADC. The combination of elevated serum CEA and CA125 was significantly associated with FIGO stage, body mass index (BMI) and LNM. Kaplan-Meier survival curve and Cox regression analyses revealed that CEA and CA125 might have significant prognostic implications in early-stage ADC patients, and the combination of elevated serum CEA and CA125 served as an independent predictor of early-stage ADC. The optimal cutoff point of serum CA125 for prediction DFS and OS was 32.60 U/mL and of serum CEA were 2.85 ng/mL and 2.05 ng/mL, respectively. The AUC showed that serum CEA was a moderate predictor of OS. Conclusion: The preoperative serum levels of CEA and CA125 might have significant prognostic implications in early-stage ADC patients. Combined preoperative serum CEA and CA125 levels independently predicted the prognosis of early-stage ADC.

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“…Many recent clinical studies [11–14] have confirmed that HR-HPV testing has a higher efficiency than cytology, albeit with lower specificity. However, several large-scale studies have shown that histologically confirmed cervical adenocarcinoma is less HPV-dependent than squamous cell carcinoma in paraffin-embedded samples [6, 19, 20, 22]. Moreover, adenocarcinoma represents a heterogeneous group with different histological subtypes, which are strongly, weakly, or irrelevantly related to HR-HPV infections [21–23, 37, 38].…”

Section: Discussionmentioning

confidence: 99%

“…However, the effectiveness of cytological screening is predominantly attributable to a reduction in the incidence of cervical squamous cell carcinoma rather than adenocarcinoma [1–5]. Adenocarcinoma is much less common than squamous cell carcinoma, accounting for only approximately 7–17% of all cervical malignancies [6–8]. In nations with well-organized screening programs, the proportion of cervical adenocarcinoma has risen in recent decades [1–5].…”

Section: Introductionmentioning

confidence: 99%

“…Based on this, HR-HPV detection, either alone or in conjunction with cytology, has been approved as a primary cervical screening modality in many developed nations [17, 18]. However, HPV infection is less prevalent in adenocarcinoma than in squamous cell carcinoma, with the former showing HPV-infection rates ranging from 60.0 to 85.8% [6, 19–23]. Accordingly, it is reasonable to postulate that the new primary screening strategy based on HR-HPV detection alone may be ineffective for the detection of cervical adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

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Prior cervical cytology and high-risk HPV testing results for 311 patients with invasive cervical adenocarcinoma: a multicenter retrospective study from China’s largest independent operator of pathology laboratories

et al. 2019

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BackgroundHigh-risk human papillomavirus (HR-HPV) testing is more sensitive than cytology for the detection of cervical cancer and its precursors. However, limited and inconsistent data are available about the efficacy of the combination of these two methods for screening cervical adenocarcinoma. This multicenter retrospective study investigated the screening results of a cohort of Chinese patients who were subsequently diagnosed with invasive cervical adenocarcinoma, with the goal of identifying the optimal cervical adenocarcinoma screening method.MethodsWe retrospectively retrieved and analyzed the data from patients with histologically confirmed primary invasive cervical adenocarcinoma from eight local pathology laboratories operated by KingMed Diagnostics, the largest independent operator of pathology laboratories in China, over a 2-year period. Only patients who underwent cytology and/or HR-HPV testing within 6 months before the adenocarcinoma diagnosis were included. HR-HPV DNA was detected using one of two HPV test kits: the Hybrid Capture 2 (HC2) assay (Qiagen, Hilden, Germany) and an HPV genotyping panel (Yaneng Bio, Shenzhen, China).ResultsOf the 311 patients, 136 underwent cytology alone, 106 underwent HR-HPV testing alone, and 69 underwent cytology and HR-HPV co-testing. The sensitivities of cytology alone (64.0, 95% confidence interval [CI]: 55.9–72.0) and HR-HPV testing alone (66.0, 95% CI: 57.0–75.1) were similar (P = 0.738). The sensitivity of cytology and HR-HPV co-testing (87.0, 95% CI: 79.0–94.9) was significantly higher than that of either cytology (P = 0.001) or HR-HPV testing alone (P = 0.002).ConclusionsBoth cytology alone and HR-HPV testing alone showed poor screening efficiency, whereas the combination of the two clearly increased the efficiency of primary cervical adenocarcinoma screening. Thus, cytology and HR-HPV co-testing might be the most efficient cervical adenocarcinoma screening method.

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The Variable Characteristics of Human Papillomavirus in Squamous Cell Carcinoma and Adenocarcinoma of Cervix in China

Abstract: Human papillomavirus infection was identified more often in SCC than in CADC. Women with HPV-associated cancers, especially HPV-16/HPV-18, were of a younger age at diagnosis when compared with non-HPV-associated cancers.

Cited by 19 publications

References 33 publications

Transcriptome analysis uncovers the diagnostic value of miR-192-5p/HNF1A-AS1/VIL1 panel in cervical adenocarcinoma

Transcriptome analysis uncovers the diagnostic value of miR-192-5p/HNF1A-AS1/VIL1 panel in cervical adenocarcinoma

<p>Combined Evaluation of Preoperative Serum CEA and CA125 as an Independent Prognostic Biomarker in Patients with Early-Stage Cervical Adenocarcinoma</p>

Prior cervical cytology and high-risk HPV testing results for 311 patients with invasive cervical adenocarcinoma: a multicenter retrospective study from China’s largest independent operator of pathology laboratories

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