The variability of urine proteome and coupled biochemical blood indicators in cosmonauts with different preflight autonomic status

Pastushkova, L. H.; Rusanov, V. V.; Орлов, О. И.; Гончарова, А. Г.; Chernikova, Anna G.; Каширина, Д. Н.; Kussmaul, A.R.; Brzhozovskiy, Alexander G.; Kononikhin, Alexey; Kireev, K.S.; Nosovsky, A. M.; Nikolaev, Evgeny N.; Ларина, И. М.

doi:10.1016/j.actaastro.2019.12.015

Cited by 5 publications

(2 citation statements)

References 22 publications

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“…In our next report ( Pastushkova et al, 2020 ), these differences were confirmed by the fact that some biochemical parameters, were unidirectionally changed with three proteins on the 1-st and 7-the days after SF. These sets were totally different in classified groups.…”

Section: Proteomic Profiling In Space Flight Ground Model Experiments...supporting

confidence: 52%

Possibilities of Proteomics Profiling in Predicting Dysfunction of the Cardiovascular System

et al. 2022

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Section: Proteomic Profiling In Space Flight Ground Model Experiments...supporting

confidence: 52%

Possibilities of Proteomics Profiling in Predicting Dysfunction of the Cardiovascular System

et al. 2022

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“…In previous studies of the cosmonauts’ urine proteome, we identified various groups of proteins associated with heart rhythm regulation ( Pastushkova et al, 2019 , 2020 ). It was shown that the urine proteome in individuals with the predominance of sympathetic and parasympathetic regulation differed in three proteins: cadherin-13, mucin-1, alpha-1 of collagen subunit type VI, which does not contradict, but complements the results of the blood proteome described above.…”

Section: Discussionmentioning

confidence: 99%

Blood Plasma Proteins Associated With Heart Rate Variability in Cosmonauts Who Have Completed Long-Duration Space Missions

et al. 2021

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The study presents the results of evaluating the changes in the concentrations of blood plasma proteins associated with heart rate variability (HRV) in cosmonauts who have completed space missions lasting about 6months. The concentrations of 125 proteins were quantified in biological samples of the cosmonauts’ blood plasma. The subgroups of proteins associated with the physiological processes of the HRV autonomic regulation were identified using bioinformatic resources (Immunoglobulin heavy constant mu, Complement C1q subcomponent subunit C, Plasma serine protease inhibitor, Protein-72kDa type IV collagenase, Fibulin-1, Immunoglobulin lambda constant 3). The concentration of these proteins in the blood plasma before the flight, and the dynamics of concentration changes on the 1st and 7th days of the post-flight rehabilitation period differed in the groups of cosmonauts with a predominance of sympathetic or parasympathetic modulating autonomous influences. The dynamics of changes in the concentrations of the identified set of proteins reveal that in cosmonauts with a predominance of sympathetic modulating influences, the mechanisms of autonomic regulation are exposed to significant stress in the recovery period immediately after the completion of the space mission, compared with the cosmonauts with a predominance of parasympathetic modulating influences.

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Correlation Between Invariable Blood Proteins and Heart Rate Variability in Long-Duration Space Flights

Pastushkova,

Rusanov,

Goncharova

et al. 2024

Microgravity Sci. Technol.

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The variability of urine proteome and coupled biochemical blood indicators in cosmonauts with different preflight autonomic status

Cited by 5 publications

References 22 publications

Possibilities of Proteomics Profiling in Predicting Dysfunction of the Cardiovascular System

Possibilities of Proteomics Profiling in Predicting Dysfunction of the Cardiovascular System

Blood Plasma Proteins Associated With Heart Rate Variability in Cosmonauts Who Have Completed Long-Duration Space Missions

Correlation Between Invariable Blood Proteins and Heart Rate Variability in Long-Duration Space Flights

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