The Variability of Overnight Urinary Albumin Excretion in Insulin‐Dependent Diabetic and Normal Subjects

Cohen, David; Close, C. F.; Viberti, Giancarlo

doi:10.1111/j.1464-5491.1987.tb00905.x

Cited by 87 publications

(32 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is a considerable intraindividual variability in AERs; the CVb previously reported ranged between 25 and 62% (13)(14)(15)(16). In the present study, we confirmed the high intra-individual biological variation of AER (64%), thus supporting the view that it is necessary to consider this confounding factor when evaluating changes of AER after clinical intervention.…”

Section: Research Design and Methods -From January 2002 Tosupporting

confidence: 79%

Albumin Excretion Rate Is Not Affected by Asymptomatic Urinary Tract Infection

Hernández

Simó

2004

Diabetes Care

View full text Add to dashboard Cite

OBJECTIVE—The aim of the study was to evaluate whether asymptomatic urinary tract infection (UTI) significantly influences the level of albumin excretion rate (AER) in diabetic patients. RESEARCH DESIGN AND METHODS—We screened prospectively for UTI and AER in 765 type 2 diabetic subjects. AER was determined before and after antimicrobial therapy in those patients in whom an asymptomatic UTI was diagnosed (n = 59). To interpret the clinical significance of AER changes, the coefficient of biological variation (CVb) of the AER (CVb-AER) was assessed in a control group of type 2 diabetic patients without UTI (n = 56). RESULTS—AER did not change after antimicrobial treatment either in the whole group of patients with UTI (pre: 13.8 μg/min [0.1–195] vs. post: 8.5 μg/min [0.1–185]; P = 0.1) or in those patients in whom the infection was eradicated (pre: 11.7 μg/min [0.1–195] vs. post: 7.1 μg/min [0.1–185]; NS). The CVb-AER was 64% in the control group and was inversely correlated with AER (r = −0.44; P = 0.001). The decrease of AER after antimicrobial therapy (55%) did not exceed the biological variation of AER (64%). Finally, UTI did not significantly influence the classification of diabetic patients as normo- or microalbuminuric. CONCLUSIONS—Asymptomatic UTI does not increase AER in type 2 diabetic patients. Therefore, our results suggest that testing for UTI is not necessary when AER is measured in diabetic patients.

show abstract

Section: Research Design and Methods -From January 2002 Tosupporting

confidence: 79%

Albumin Excretion Rate Is Not Affected by Asymptomatic Urinary Tract Infection

Hernández

Simó

2004

Diabetes Care

View full text Add to dashboard Cite

show abstract

“…Prior studies suggested that urinary albumin levels may exhibit intraindividual variability. 28,29) However, national practice guidelines recommend the use of spot specimens for ACR because the results correlate well with those of 24-hour collections.…”

Section: Discussionmentioning

confidence: 99%

Impact of Supervised Cardiac Rehabilitation on Urinary Albumin Excretion in Patients With Cardiovascular Disease

et al. 2015

View full text Add to dashboard Cite

SummaryUrinary albumin excretion is a predictor of cardiovascular death. Cardiac rehabilitation (CR) with exercise training (ET) has been shown to improve exercise capacity and prognosis in patients with cardiovascular disease (CVD). However, it remains unclear whether CR reduces urinary albumin excretion in CVD patients. We performed a retrospective, observational study using data obtained from 98 male CVD patients without macroalbuminuria and estimated glomerular filtration rate (eGFR) < 30 mL/minute/1.73 m 2 who participated in CR with ET during hospitalization. Twenty-three patients continued supervised ET for 6 months (supervised group) and 75 patients quit supervised ET (non-supervised group). The supervised ET program consisted of 60 minutes of supervised sessions 1-3 times a week and 30-60 minutes of home exercise at least twice a week. Urinary albumin/creatinine ratio (ACR) was significantly decreased in the supervised group at 6 months after enrollment (43 ± 71 mg/g to 17 ± 20 mg/g creatinine, P < 0.05) but not in the non-supervised group. eGFR was unchanged in the supervised group but was significantly decreased in the non-supervised group (72 ± 18 mL/minute/1.73 m 2 to 67 ± 17 mL/minute/1.73 m 2 , P < 0.001). The results of multiple regression analysis showed that only supervised ET was an independent contributor to ΔACR. CR with supervised ET decreased urinary albumin excretion without deterioration of renal function. These findings suggest that continuation of a supervised ET program is associated with reduction in the development of CVD and reduction in cardiovascular morbidity and mortality in CVD patients. (Int Heart J 2015; 56: 105-109) Key words: Supervised exercise training U rinary albumin excretion has long been recognized as a risk factor for progression to end-stage renal failure in individuals in the general population as well as individuals with hypertension or diabetes mellitus. Recently, urinary albumin excretion has been shown to be associated with an increased incidence of all-cause and cardiovascular morbidity and mortality in general populations and in patients with hypertension or diabetes mellitus. [1][2][3] In addition, low levels of urinary albumin excretion well below the current microalbuminuria threshold have been shown to predict the development of CVD. 4,5) CR with ET has been shown to improve exercise capacity and prognosis in CVD patients.6) Medications such as angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), and statins have also been reported to improve prognosis in CVD patients. In addition, these medications reduce urinary albumin excretion.7-9) However, it remains unclear whether CR ameliorates albuminuria in patients with CVD.The purpose of the present study was to clarify the effect of CR on urinary albumin excretion in patients with CVD.

show abstract

“…Cohen et al 28 used a ratio of microalbuminuria to urine creatinine in single voided urine of 2.6 and found that using this ratio and above will identify all patients with an initial albumin excretion rate greater than 30 μg/min. Calculation of albumin over creatinine ratio is designed to reduce errors which can occur due to incomplete or incorrectly timed collection in addition to being more practical and convenient for the patients.…”

Section: Discussionmentioning

confidence: 99%

The Pattern of Diabetic Nephropathy Among Saudi Patients with Noninsulin-Dependent Diabetes Mellitus

Huraib

Abu‐Aisha²,

Sulimani³

et al. 1995

Ann Saudi Med

View full text Add to dashboard Cite

There were no studies on the different stages of diabetic nephropathy in Saudi Arabia, particularly the earliest stages. We have therefore investigated the frequency of occurrence of varying degrees of proteinuria including microalbuminuria in noninsulin-dependent diabetes mellitus (NIDDM) Saudi patients as well as the correlation of varying degrees of proteinuria with other diabetic complications and risk factors. One hundred and twenty-five NIDDM patients were studied. Fifty-seven were males and 68 were females. Their mean age was 49.8 ± 10 years with a mean duration of diabetes of 9.48 ± 6 years. The mean of HbAlc was 10.3 ± 2.6%, serum creatinine was 76.7 ± 23 mmol/L, creatinine clearance 94.3 mL/min, glomerular filtration rate 129.7 ± 44 and effective renal plasma flow was 496.5 ± 153. The pattern of proteinuria group was as follows: nephrotic range proteinuria 5.6%, clinical proteinuria 30.4%, microalbuminuria 16.8%. Hypertension and retinopathy were present in 36.8% and 37% of the patients respectively. A significant correlation was found between the presence of hypertension, duration of diabetes and development of diabetic nephropathy. Similarly, a significant correlation was found between retinopathy and the degree of proteinuria. In conclusion, the pattern of diabetic nephropathy in the Saudi NIDDM patients is similar to that in the Western world. Hypertension and duration of diabetes mellitus are important risk factors in the development of diabetic nephropathy. There is a good correlation between retinopathy and the degree of proteinuria. Ann Saudi Med 1995;15(2):120-124.

show abstract

The Variability of Overnight Urinary Albumin Excretion in Insulin‐Dependent Diabetic and Normal Subjects

Cited by 87 publications

References 15 publications

Albumin Excretion Rate Is Not Affected by Asymptomatic Urinary Tract Infection

Albumin Excretion Rate Is Not Affected by Asymptomatic Urinary Tract Infection

Impact of Supervised Cardiac Rehabilitation on Urinary Albumin Excretion in Patients With Cardiovascular Disease

The Pattern of Diabetic Nephropathy Among Saudi Patients with Noninsulin-Dependent Diabetes Mellitus

Contact Info

Product

Resources

About