Abstract:Patients with ankylosing spondylitis (AS) have an increased risk of developing osteoporosis, mainly caused by systemic inflammation and decreased mobility (1). For this reason, patients with AS demonstrate an increased risk of fractures, especially vertebral fractures, in comparison with the general population (2). However, measurements of areal bone mineral density (aBMD) are overestimated and unreliable in AS patients, because of the presence of osteo-proliferation and syndesmophytes. Significantly increased… Show more
“…Other studies have also report that TBS accurately diagnosed axial osteoporosis in the early stages of AS, while BMD is not a reliable tool. Moreover, TBS is reported to be capable of predicting spine fractures independent of FRAX in AS patients [45][46][47].…”
Section: Tbs Application In Ankylosing Spondylitis (As) and Rheumatoid Arthritis (Ra)mentioning
Assessment of bone health is essential in many different diseases and conditions, including osteoporosis and fragility fracture. Although bone mineral density (BMD) has a well-established role in measuring bone quantity, it is unable to determine bone quality. Recently, the trabecular bone score (TBS) was developed as a valuable approach to determining bone quality by evaluating the microarchitecture of a bone. TBS data is of critical importance, particularly in conditions in which BMD is falsely elevated or has not yet decreased significantly. The current review has collected current evidence regarding the clinical applications of TBS in various disorders, such as osteoporosis, fracture, diabetes, chronic kidney disease, and degenerative bone diseases.
“…Other studies have also report that TBS accurately diagnosed axial osteoporosis in the early stages of AS, while BMD is not a reliable tool. Moreover, TBS is reported to be capable of predicting spine fractures independent of FRAX in AS patients [45][46][47].…”
Section: Tbs Application In Ankylosing Spondylitis (As) and Rheumatoid Arthritis (Ra)mentioning
Assessment of bone health is essential in many different diseases and conditions, including osteoporosis and fragility fracture. Although bone mineral density (BMD) has a well-established role in measuring bone quantity, it is unable to determine bone quality. Recently, the trabecular bone score (TBS) was developed as a valuable approach to determining bone quality by evaluating the microarchitecture of a bone. TBS data is of critical importance, particularly in conditions in which BMD is falsely elevated or has not yet decreased significantly. The current review has collected current evidence regarding the clinical applications of TBS in various disorders, such as osteoporosis, fracture, diabetes, chronic kidney disease, and degenerative bone diseases.
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