The Value of Thioredoxin Family Proteins and Proliferation Markers in Dysplastic and Malignant Gallbladders in Patients with Primary Sclerosing Cholangitis

Said, Karouk; Glaumann, Hans; Björnstedt, Mikael; Bergquist, Annika

doi:10.1007/s10620-012-2089-4

Cited by 7 publications

(7 citation statements)

References 35 publications

(46 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this regard, 2 patients exhibiting high grade dysplasia had a pre-operative diagnosis of primary sclerosing cholangitis, a known risk factor for gallbladder malignancy with previous reports of up to 30% of resected gallbladders displaying dysplasia/carcinoma pathology[17]. Consistent with this, our policy is to adopt a low threshold in recommending cholecystectomy in patients with primary sclerosing cholangitis presenting with clinical or radiological evidence of gallbladder pathology.…”

Section: Discussionsupporting

confidence: 69%

Incidental non-benign gallbladder histopathology after cholecystectomy in an United Kingdom population: Need for routine histological analysis?

Patel¹,

Dajani²,

Iype³

et al. 2016

WJGS

View full text Add to dashboard Cite

AIMTo analyse the range of histopathology detected in the largest published United Kingdom series of cholecystectomy specimens and to evaluate the rational for selective histopathological analysis.METHODSIncidental gallbladder malignancy is rare in the United Kingdom with recent literature supporting selective histological assessment of gallbladders after routine cholecystectomy. All cholecystectomy gallbladder specimens examined by the histopathology department at our hospital during a five year period between March 2008 and March 2013 were retrospectively analysed. Further data was collected on all specimens demonstrating carcinoma, dysplasia and polypoid growths.RESULTSThe study included 4027 patients. The majority (97%) of specimens exhibited gallstone or cholecystitis related disease. Polyps were demonstrated in 44 (1.09%), the majority of which were cholesterol based (41/44). Dysplasia, ranging from low to multifocal high-grade was demonstrated in 55 (1.37%). Incidental primary gallbladder adenocarcinoma was detected in 6 specimens (0.15%, 5 female and 1 male), and a single gallbladder revealed carcinoma in situ (0.02%). This large single centre study demonstrated a full range of gallbladder disease from cholecystectomy specimens, including more than 1% neoplastic histology and two cases of macroscopically occult gallbladder malignancies.CONCLUSIONRoutine histological evaluation of all elective and emergency cholecystectomies is justified in a United Kingdom population as selective analysis has potential to miss potentially curable life threatening pathology.

show abstract

Section: Discussionsupporting

confidence: 69%

Incidental non-benign gallbladder histopathology after cholecystectomy in an United Kingdom population: Need for routine histological analysis?

Patel¹,

Dajani²,

Iype³

et al. 2016

WJGS

View full text Add to dashboard Cite

show abstract

“…All of the three cases with metastatic disease in our study showed Cyclin D1 expression suggesting a positive relation between tumor metastasis and Cyclin D1 expression (x 2 =5.114, p value=0.024, R=0.452, p value=0.012). Our results are in line with those of Said et al (2012) for Cyclin D1.…”

Section: F I G U Re 2 P H O T O M I C Ro G R a P H S H O W I N G P 1supporting

confidence: 92%

Cyclin D1, Retinoblastoma and p16 Protein Expression in Carcinoma of the Gallbladder

Srivastava¹,

Patel²,

Kumar³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: Cancer of the gallbladder is a relatively rare neoplasm with a poor prognosis. The exact mechanisms of its genesis are not known and very little information is available on molecular events leading to labeling this as an orphan cancer. Materials and Methods: In this prospective case control study we evaluated the expression of p16, pRb and cyclin D1 by immunohistochemistry to study the G1-S cell-cycle check point and its possible role in gallbladder carcinogenesis. A total of 25 patients with gallbladder carcinoma (group I), 25 with cholelithiasis (group II) and 10 normal controls. were enrolled Results: Cyclin D1 expression was seen in 10 (40%) patients each with carcinoma and cholelithiasis while only in 2 (20%) of the normal gallbladders but differences were not statistically significant (p value=0.488). p16 was expressed in 12% patients of carcinoma of the gallbladder and 28% of cholelithiasis, however this difference was not statistically significant (p value=0.095). Retinoblastoma protein was found to be expressed in 50% of normal gallbladders and 6 (24%) of carcinoma and 8 (32%) of gallstones. The present study failed to demonstrate any conclusive role of cyclin D1/RB/ p16 pathway in carcinoma of the gallbladder. Conclusions: The positive relation observed between tumor metastasis and cyclinD1 expression and p16 with nodal metastasis suggested that higher cyclin D1/p16 expression may act as a predictive biomarker for aggressive behavior of gallbladder malignancies.

show abstract

“…In those patients with benign masses, 33% had associated epithelial dysplasia, while in patients with primary GBC, 57% had associated dysplasia [126]. In another study, gallbladder dysplasia/carcinoma was found in 30% of operative specimens, and evidence of inflammation and fibrosis of the gallbladder wall was found in nearly half of gallbladder dysplasias and carcinomas, respectively [127]. As exemplified by PSC, autoimmune diseases probably increase risk of GBC via exacerbation of biliary inflammation.…”

Section: Other Inflammatory Pathologies That Predispose To Gallbladdementioning

confidence: 99%

The inflammatory inception of gallbladder cancer

Espinoza

Bizama

García

et al. 2016

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

115

View full text Add to dashboard Cite

Gallbladder cancer is a lethal disease with notable geographical variations worldwide and a predilection towards women. Its main risk factor is prolonged exposure to gallstones, although bacterial infections and other inflammatory conditions are also associated. The recurrent cycles of gallbladder epithelium damage and repair enable a chronic inflammatory environment that promotes progressive morphological impairment through a metaplasia–dysplasia–carcinoma, along with cumulative genome instability. Inactivation of TP53, which is mutated in over 50% of GBC cases, seems to be the earliest and one of the most important carcinogenic pathways involved. Increased cell turnover and oxidative stress promote early alteration of TP53, cell cycle deregulation, apoptosis and replicative senescence. In this review, we will discuss evidence for the role of inflammation in gallbladder carcinogenesis obtained through epidemiological studies, genome-wide association studies, experimental carcinogenesis, morphogenetic studies and comparative studies with other inflammation-driven malignancies. The evidence strongly supports chronic, unresolved inflammation as the main carcinogenic mechanism of gallbladder cancer, regardless of the initial etiologic trigger. Given this central role of inflammation, evaluation of the potential for GBC prevention removing causes of inflammation or using anti-inflammatory drugs in high-risk populations may be warranted.

show abstract

The Value of Thioredoxin Family Proteins and Proliferation Markers in Dysplastic and Malignant Gallbladders in Patients with Primary Sclerosing Cholangitis

Cited by 7 publications

References 35 publications

Incidental non-benign gallbladder histopathology after cholecystectomy in an United Kingdom population: Need for routine histological analysis?

Incidental non-benign gallbladder histopathology after cholecystectomy in an United Kingdom population: Need for routine histological analysis?

Cyclin D1, Retinoblastoma and p16 Protein Expression in Carcinoma of the Gallbladder

The inflammatory inception of gallbladder cancer

Contact Info

Product

Resources

About