The Value of the Thyrotropin Stimulation Test in the Diagnosis of Myxoedema

Diagnostic Value of 131I in Thyroid Disorders

“…The thyrotrophin stimulation test, performed on 64 patients, showed results in accordance with previous studies on this subject (1,6,14), except for the fact that one patient with thyrogenic myxoedema showed some increase and that one patient with pituitary myoxedema failed to show an increase, presumably because the gland had undergone atrophy. That half the patients with acute thyroiditis showed increased uptakes is at variance with the experience of Skillern et al (24).…”

“…The PB1311 was determined 24 hours after the administration of 1311 on a precipitate obtained by adding 40 '$6 trichloracetic acid to a blood sample and washing 3 times with equal parts of 10 yo trichloracetic acid and a solution of potassium iodide. The thyrotrophin stimulation test was performed by the technique described previously (6). According to Friis and Korsgaard Christensen the normal values for 4-hour uptake are 15-45 yn and for the 24-hour uptake 30-70 Yn of the dosage.…”

“…At 24 hours the PB1311 in the serum is measured. This In order to ascertain whether a patient on thyroid medication is actually suffering from thyrogenic myxoedema, a thyrotrophin stimulation often has to be done, as in these patients the thyroid gland very seldom takes up iodide, even in the absence of myxoedema, because the glandular function is inhibited by the treatment (1,6,14). As is well-known, this stimulation test is also of interest in differentiating between thyrogenic and pituitary myxoedema.…”