The Value of the Monocyte to High-Density Lipoprotein Cholesterol Ratio in Assessing the Severity of Knee Osteoarthritis: A Retrospective Single Center Cohort Study

Abstract

Background Inflammatory responses and metabolic abnormalities play essential roles in the pathophysiology of osteoarthritis (OA). Our study aimed to evaluate the association between monocyte-to-high density lipoprotein-cholesterol ratio (MHR) and OA and compared it with other systemic inflammatory markers. Methods This study recruited 323 OA cases and age- and sex-matched 283 control participants during the same period. Demographic, clinical, and imaging data and laboratory indicators were obtained from participants’ records. Systemic inflammatory markers were calculated for both cohorts. The diagnostic effectiveness of each index for distinguishing patients with OA was analyzed using receiver operating characteristic (ROC) curves. Spearman’s method and ordered logistic regression were used to analyze the association between each indicator and Kellgren and Lawrence (KL) grade. Results MHR was significantly higher (0.38±0.18 vs 0.25±0.07, p < 0.0001) in OA patients than healthy controls. MHR had the largest area under the ROC curve for predicting OA. Analysis of ordered logistic regression indicated that MHR was a risk factor for OA radiological severity. Spearman correlation analysis indicated that MHR significantly correlates with the KL grade. Moreover, MHR was significantly higher in early stage patients than in healthy controls. Conclusion These results suggest that an elevated MHR could reflect knee OA severity and might be a useful marker for diagnosis and monitoring of OA.

The Ratio of Monocytes to HDL-Cholesterol Is Associated with Cardiovascular Risk and Insulin Resistance in Patients with Rheumatoid Arthritis

“…However, there is some information on MHR in inflammatory or musculoskeletal diseases. In a previous study that included 323 patients with knee osteoarthritis and 283 age-and sexmatched controls, MHR was significantly higher in patients than in healthy controls [28]. Moreover, MHR significantly correlated with the radiological severity.…”

Association Between Monocyte-to-High-Density Lipoprotein Ratio and Prediabetes: A Cross-Sectional Study in Chinese Population

“…41 In addition, MHR has been indicated to have greater diagnostic significance in conditions such as tuberculosis and osteoarthritis. 42,43 In the prediabetic stage, an increase in monocytes count and pro-inflammatory subtypes has been observed. 18 In a 5-year cohort study, it was found that the dysregulation of circulating immune cells and inflammatory factors was associated with dynamic disruptions in glucose metabolism.…”